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Synfacts 2008(10): 1093-1093  
DOI: 10.1055/s-2008-1078228
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Pd-Catalyzed Borylation of Aryl Halides Using Pinacol Borane

Contributor(s): Paul Knochel, Andreas J. Wagner
K. L. Billingsley, S. L. Buchwald*
Massachusetts Institute of Technology, Cambridge, USA
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Publication History

Publication Date:
22 September 2008 (online)

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Significance

This work presents a novel method for the direct borylation of aryl halides using pinacol borane as an inexpensive and atom-economical boron source. Aryl and heteroaryl iodides, bromides and chlorides, containing a variety of functional groups, are converted into the corresponding pinacol boronate esters in good to excellent yields.