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Synlett 2008(16): 2421-2424
DOI: 10.1055/s-2008-1078208
DOI: 10.1055/s-2008-1078208
LETTER
© Georg Thieme Verlag
Stuttgart ˙ New York
A Convenient Synthesis of Highly Substituted 3-N,N-Dialkylamino-1,2,4-triazoles
Weitere Informationen
Received
1 May 2008
Publikationsdatum:
22. August 2008 (online)
Publikationsverlauf
Publikationsdatum:
22. August 2008 (online)
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Abstract
The title compounds are prepared from S-methylisothioureas and acyl hydrazides in moderate to good yields. The reaction is characterized by relatively mild conditions and very broad functional group tolerance.
Key words
heterocycles - cyclisations - sulfur - medicinal chemistry - drugs
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References and Notes
This avoided the use of the carcinogenic MeI and gave the S-methylisothiourea as the free base rather than the HI salt thereby allowing for simpler assessment of the role of acid in the cyclisation reaction.