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Synfacts 2008(10): 1010-1010  
DOI: 10.1055/s-2008-1078183
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Lobotoside E

Contributor(s): Philip Kocienski
C. Zhu, P. Tang, B. Yu*
Shanghai Institute of Organic Chemistry, P. R. of China
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Publication History

Publication Date:
22 September 2008 (online)

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Significance

Lobotoside E is a potent growth inhibitor of various human tumor cell lines. The bayogenin derivative J was elaborated in a series of C-O bond-forming reactions (numbered in sequence) to create the macrocycle.