Download PDF
Synfacts 2008(10): 1080-1080  
DOI: 10.1055/s-2008-1078139
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Branch-Selective Hydroformylation by Rh-Scaffolding Ligand Complexes

Contributor(s): Hisashi Yamamoto, Cheol Hong Cheon
T. E. Lightburn, M. T. Dombrowski, K. L. Tan*
Boston College, Chestnut Hill, USA
Further Information

Publication History

Publication Date:
22 September 2008 (online)

    Permissions and Reprints

Significance

This paper describes the development of a scaffolding ligand that simultaneously and reversibly binds alcohol substrates, as well as metal-based catalyst. The authors applied this strategy to the branch-selective hydroformylation. Using catalytic amounts of a scaffolding ligand, they obtained excellent regioselectivity (up to 98:2) and high branch selectivity (up to 88:12) for terminal olefins.