Enantioselective Intermolecular 1,3-Dipolar Cycloaddition

Significance

Carbon ylide cycloadditions have proven utility in total synthesis to build complex structures rapidly. The authors have designed a chiral catalyst that overcomes previous limitations which restricted the reaction to electron-deficient dipolarophiles (S.-i. Hashimoto and co-workers J. Am. Chem. Soc. 1999, 121, 1417). High enantioselectivity in intermolecular reactions allows the synthesis of complex chiral oxabicyclic structures.