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Synfacts 2008(8): 0894-0894
DOI: 10.1055/s-2008-1077921
DOI: 10.1055/s-2008-1077921
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Aminocarbonylation Inside a Flow Reactor
C. Csajági*, B. Borcsek, K. Niesz, I. Kovács, Z. Székelyhidi, Z. Bajkó, L. Ürge, F. Darvas
ThalesNano Inc., Budapest, Hungary
Further Information
Publication History
Publication Date:
23 July 2008 (online)
![](https://www.thieme-connect.de/media/synfacts/200808/lookinside/thumbnails/10.1055-s-2008-1077921-1.jpg)
Significance
Haloganated arenecarboxylic acids were converted into the corresponding dicarboxylic acid monoamides by aminocarbonylation mediated by a supported Pd catalyst inside a flow reactor (X-CubeTM). Thus, a gas-liquid mixture of CO gas and a THF solution of 4-iodobenzoic acid, pyrrolidine and triethylamine was passed with a 0.5 mL/min flow rate at 100 ˚C through a cartridge (CatCartTM) where polymer-supported tetrakis(triphenylphosphine)palladium was packed. The corresponding dicarboxylic acid monoamides were obtained in 25-81% yield (13 examples) within two minutes of the residence time.