Download PDF
Synfacts 2008(8): 0832-0832  
DOI: 10.1055/s-2008-1077907
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed Enantioselective [4+2] and [2+2] Cycloadditions

Contributor(s): Mark Lautens, Praew Thansandote
K. Ishihara*, M. Fushimi
Nagoya University, Japan
Further Information

Publication History

Publication Date:
23 July 2008 (online)

    Permissions and Reprints

Significance

Copper-catalyzed enantioselective [4+2] and [2+2] cycloadditions are reported for an acetylene derivative (propiolamide) and various cyclic dienes and enol ethers. Simple dienes containing one substituent or no substituents participated in the [4+2] cycloaddition, whereas enol ethers and highly substituted dienes participated in the [2+2] cycloaddition.