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Synfacts 2008(7): 0672-0672  
DOI: 10.1055/s-2008-1077870
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (+)-Achalensolide

Contributor(s): Philip Kocienski, Arndt W. Schmidt
T. Hirose, N. Miyakoshi, C. Mukai*
Kanazawa University, Japan
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Publication History

Publication Date:
20 June 2008 (online)

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Significance

(+)-Achalensolide was isolated from several plants and is a potent inhibitior of the aromatase enzyme. The present work utilizes a modified Rh-catalyzed Pauson-Khand reaction to generate the bicyclo[5.3.0]decenone motif, which is not easily accessible by standard protocols.