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Planta Med 1980; 40(10): 104-108
DOI: 10.1055/s-2008-1074946
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Mutational Biosynthesis in a Strain of Claviceps purpurea1

W. Maier, D. Erge, D. Gröger
  • Institute of Plant Biochemistry, Academy of Sciences of the GDR, DDR-4010 Halle/Saale, Weinberg 3
1 Dedicated to Professor Dr. Drs. h. C. K. MOTHES on the occasion of his eightieth birthday.
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Publication Date:
29 April 2008 (online)

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Abstract

An alkaloid-blocked mutant of Claviceps purpurea was isolated from an ergotoxine producing strain. It accumulates chanoclavine I and the corresponding aldehyde. The formation of agroclavine is blocked in this particular strain. By feeding with appropriate intermediates (tetracyclic ergolines) the mutant produces the normal alkaloidal spectrum of the parent strain. Surprisingly, after supplementation with agroclavine, ergosine is synthesized.

Key Word Index

Claviceps purpurea - Ergotoxines - Blocked Mutant - Secoergoline Accumulation - Mutasynthesis.