Untersuchungen zur Elimination von Silymarin bei cholezystektomierten Patienten

Abstract

Following a single oral administration of 140 mg Silymarin (Legalon^® sugar-coated tablets) the components silybin and silychristin were determined in the bile of 9 cholecystectomized patients with T-drainage. Both isomers were excreted in the form of sulphate and glucuronide conjugates. Silydianin, the third component of Silymarin, could not be detected in an unchanged form.

Silybin, the main component of sily-mann, was found in concentrations of 10-50 μg/ml bile; these are concentrations which in animal experiments have shown an antihepatotoxic effect. The elimination of silybin lasts for approx. 24 h. The bile collected during this period contains 7-15 % of the orally administered silybin. The bile collected through the T-tube, however, represents only a part of the total output, so that the amount of silybin eliminated must be estimated as to be 2-3 times higher, i.e. approx. 20-40 %. Since renal excretion of silybin is only 3-7 % in healthy test persons and as in the urine of cholecystectomized patients only very small amounts could be detected, silybin is primarily eliminated via the bile.

1.3-3.3 % of die administered silychristin was found in the 24 h-bile, so that total biliary elimination is roughly 4-10 %.

Key Word Index

Silybum marianum - Compositae - Silymarin - Silybin - Silydianin - Silychristin - Elimination - Cholezystektomierte Patienten