Rofo 2008; 180 - VO_409_6
DOI: 10.1055/s-2008-1073842

Similar low rate of contrast induced nephropathy compared to a control group using Iodixanol for repeated Cerebral Perfusion Computed tomography in case of suspected brain ischemia

S Langner 1, S Stumpe 1, M Kirsch 1, M Petrik 1, CP Fröhlich 1, N Hosten 1
  • 1Ernst-Moritz-Arndt-Universität Greifswald, Institut für Diagnostische Radiologie und Neuroradiologie, Greifswald

Ziele: Contrast-induced nephropathy is one of the most common causes of in-hospital acute renal failure. In case of suspected brain ischemia, CT perfusion imaging allows to rapidly depict the salvageable tissue at risk. The aim of this study was to assess the risk of contrast-induced nephropathy (CIN) after repeated administration of the dimeric, iso-osmolal contrast agent iodixanol for cerebral perfusion CT regardless of preexisting renal function. Changes in serum creatinine (SCr) are compared to a control group that did not receive iodinated contrast media. Methode: Between January 2005 and March 2007, 100 consecutive patients were prospectively included. Patients underwent a CT perfusion (CTP) study of the brain due to clinical signs of acute cerebral infarction. CTP was performed with an IV bolus of 60ml iodixanol 270. Pre- and postcontrast SCr levels were obtained and the CTP study was repeated within 32 hours and postcontrast SCR was assessed. Ergebnis: All patients were included in the final analysis. Mean baseline SCr was 85µmol/l ±33.63µmol/l in the contrast group and 109µmol/l ±85µmol/l in the control group.

A relative increase of ≥25% after the first contrast bolus occurred in one patient and after the second bolus in two patients. Four patients in total had a relative increase of ≥25% compared to the baseline. In the control group, a relative increase of ≥25% was seen in five patients. Schlussfolgerung: Multiple contrast-enhanced studies with intravenously administered iodixanol are not associated with a higher risk for contrast-induced nephropathy compared to a control group receiving no contrast media.

Korrespondierender Autor: Langner S

Ernst-Moritz-Arndt-Universität Greifswald, Institut für Diagnostische Radiologie und Neuroradiologie, F.-Sauerbruch-Strasse 1, 17475 Greifswald

E-Mail: soenke.langner@uni-greifswald.de

renal insufficiency - ct perfusion - iodixanol