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Synlett 2008(9): 1349-1352
DOI: 10.1055/s-2008-1072786
DOI: 10.1055/s-2008-1072786
LETTER
© Georg Thieme Verlag Stuttgart · New York
Enantiomerically Pure Cyclopropylamines via C-B to C-N Conversion
Further Information
Publication History
Received
6 March 2008
Publication Date:
07 May 2008 (online)


Abstract
For the first time cyclopropyltrifluoroborates have been utilized to form cyclopropylamines in a one-pot procedure. The scope was not only demonstrated by successfully reacting various racemic cis- and trans-2-substituted cyclopropanes as well as azides, but also by applying the sequence to enantiomerically pure building blocks. An approach to tranylcypromine as well as belactosin A is outlined.
Key words
boron - cyclopropanes - asymmetric synthesis - cyclopropylamine