Synlett 2008(9): 1349-1352  
DOI: 10.1055/s-2008-1072786
LETTER
© Georg Thieme Verlag Stuttgart · New York

Enantiomerically Pure Cyclopropylamines via C-B to C-N Conversion

Jörg Pietruszka*, Gemma Solduga
Institut für Bioorganische Chemie, Heinrich-Heine-Universität Düsseldorf, Forschungszentrum Jülich, Im Stetternicher Forst, Geb. 15.8, 52426 Jülich, Germany
Fax: +49(2461)616196; e-Mail: j.pietruszka@fz-juelich.de;
Further Information

Publication History

Received 6 March 2008
Publication Date:
07 May 2008 (online)

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Abstract

For the first time cyclopropyltrifluoroborates have been utilized to form cyclopropylamines in a one-pot procedure. The scope was not only demonstrated by successfully reacting various racemic cis- and trans-2-substituted cyclopropanes as well as azides, but also by applying the sequence to enantiomerically pure building blocks. An approach to tranylcypromine as well as belactosin A is outlined.