Synthesis of Three Lycopodium Alkaloids

T. Kozaka; N. Miyakoshi; C. Mukai

doi:10.1055/s-2008-1072700

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Synfacts 2008(5): 0452-0452
DOI: 10.1055/s-2008-1072700

Synthesis of Natural Products and Potential Drugs

Synthesis of Three Lycopodium Alkaloids

Contributor(s): Philip Kocienski, Stewart Eccles
T. Kozaka, N. Miyakoshi, C. Mukai*
Kanazawa University, Japan

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Publication History

Publication Date:
23 April 2008 (online)

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Significance

The three alkaloids were isolated from Lycopodium paniculatum and Lycopodium magellanicum and have been the subject of many synthetic studies due to the challenging tetracyclic core. Two Pauson-Khand reactions (PKR) produced the two fused bicyclic systems that constitute the structural framework of the natural products.