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Synfacts 2008(5): 0549-0549  
DOI: 10.1055/s-2008-1072555
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Ring-Opening of Epoxides with Amines by Zn(ClO4)/Al2O3

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada
M. Maheswara, K. S. V. K. Rao, J. Y. Do*
Pusan National University, Busan, Korea
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Publication History

Publication Date:
23 April 2008 (online)

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Significance

Regioselective ring-opening of epoxides with amines (1 equiv) was performed with an alumina-supported Zn(ClO4) at r.t. for 1-3 h to give the corresponding β-amino alcohols in 85-95% yield (14 examples). The Zn catalyst was prepared by mixing Zn(ClO4)·6H2O and neutral alumina in water followed by calcinations at 250 °C. The zinc catalyst was reused twice in the ring-opening amination with slight loss of catalytic activity.