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Neuropediatrics 1994; 25(1): 16-19
DOI: 10.1055/s-2008-1071575
Original article

© Georg Thieme Verlag KG Stuttgart · New York

Neurological Complications in Children with Protein C Deficiency

M. A. P. van Kuijck1 , J. J. Rotteveel2 , C. G. van Oostrom1 , I.  Novakova3
  • 1Department of Pediatrics, University Hospital Nijmegen, Nijmegen, The Netherlands
  • 2Department of Child Neurology, University Hospital Nijmegen, Nijmegen, The Netherlands
  • 3Department of Hematology, University Hospital Nijmegen, Nijmegen, The Netherlands
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Publication History

Publication Date:
15 May 2008 (online)

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Abstract

Four children with a cerebrovascular occlusive accident and protein C deficiency are described. Two patients presented with an acute hemiplegia, the others suffered from a transient ischemic attack and a progressive hydrocephalus as the result of sinus thrombosis. In all cases protein C deficiency, Type 1, was diagnosed. Other causes of cerebrovascular disease were excluded. Although venous thrombosis has been extensively reported in protein C deficiency, these cases indicate that protein C deficiency is also related to arterial thrombosis. In evaluating children with cerebrovascular accidents, protein C deficiency should also be considered.

Key words

Protein C deficiency - Cerebrovascular disorders - Childhood - Stroke