Vigabatrin in the Treatment of Infantile Spasms

J. S. H. Vles; A. M. H. G. van der Heyden; A. Ghijs; J. Troost

doi:10.1055/s-2008-1071546

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Neuropediatrics 1993; 24(4): 230-231
DOI: 10.1055/s-2008-1071546

Short communication

Vigabatrin in the Treatment of Infantile Spasms

J. S. H. Vles¹ , A. M. H. G. van der Heyden¹ , A. Ghijs² , J. Troost³

¹Department of Child Neurology, University Hospital Maastricht, Maastricht, The Netherlands
²Department of Neuropsychology, University Hospital Maastricht, Maastricht, The Netherlands
³Department of Neurology, University Hospital Maastricht, Maastricht, The Netherlands

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Publikationsdatum:
19. März 2008 (online)

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Abstract

The anti-epileptic effect of vigabatrin as a first choice therapy was investigated in 6 children suffering from infantile spasms (IS). All 6 children showed a reduction in seizure frequency. Three children became seizure-free within a period of 2 weeks. Because our results suggest "an all or nothing phenomenon", a period of 2 weeks may be sufficient to evaluate the efficacy of vigabatrin in untreated infants suffering from IS. We suggest to use vigabatrin as a first choice anti-epileptic drug in infants with IS.

Key words

Infantile spasms - Vigabatrin