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Neuropediatrics 1993; 24(3): 131-133
DOI: 10.1055/s-2008-1071529
Original article

© Georg Thieme Verlag KG Stuttgart · New York

Antibodies to ACTH in Opsoclonus-Myoclonus

M. R. Pranzatelli1 , P. C. Kao2 , E. D. Tate1 , E.  Chaves3 , M.  Chez4 , W. B. Dobyns5 , H.  Kang6 , D. A. Rothner7
  • 1Department of Neurology, Pediatrics, and Pharmacology, The George Washington University, Washington, D.C., USA
  • 2The Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
  • 3The Department of Neurology, University of Kansas, Kansas City, KS, USA
  • 4The Department of Pediatric Neurology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL, USA
  • 5The Department of Neurology and Medical Genetics, Indiana University School of Medicine, Indianapolis, IN, USA
  • 6The Department of Pediatric Neurology, Montefiore Medical Center, Bronx, NY, USA
  • 7Department of Pediatrics, Cleveland Clinic Foundation, Cleveland, OH, USA
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Publikationsdatum:
19. März 2008 (online)

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Abstract

Antibodies to ACTH1-24 detected by radioimmunoassay were present in the serum of a child with opsoclonus-myoclonus for at least 24 weeks after discontinuation of chronic ACTH treatment. The antibody-bound ACTH did not interfere with Cortisol secretion. Six other children with opsoclonus-myoclonus and 16 control sera, including patients with chronically elevated endogenous ACTH, did not exhibit autoantibodies to ACTH. Antibodies to ACTH should be sought in patients who develop tolerance to ACTH treatment. The indirect but not direct ACTH assay method is sensitive to the presence of ACTH antibodies.

Key words

Opsoclonus-myoclonus - ACTH1-39 - ACTH antibodies

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