A Convenient Synthesis of Functionalized Furans

Abstract

An efficient synthesis of substituted furans was achieved from ketones by alkylation with 3-iodopropynylphosphonate and cyclization of the resulting 5-oxo-1-ynylphosphonates under mild conditions. The process can also be carried out as a one-pot reaction to give furan derivatives in excellent yields.

Key words

furans - pent-4-ynones - furylphosphonates - cycloiso­merizations - Horner-Wadsworth-Emmons

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