Cross-Coupling of α-Diazocarbonyl Compounds with Arylboronic Acids

Significance

The first Pd-catalyzed cross-coupling reaction of α-diazocarbonyl compounds with aryl boronic acid is reported in this article. It provides a direct access to α-aryl substituted α,β-­unsaturated carbonyl compounds, whose preparation is difficult by conventional methods. Sensitive functional groups, such as nitro groups, chloro, and bromo substituents are tolerated. The reaction is supposed to proceed via a migratory insertion of an intermediary Pd-carbene species.