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Synfacts 2008(3): 0284-0284
DOI: 10.1055/s-2008-1042699
DOI: 10.1055/s-2008-1042699
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Novel Self-Assembled Titanium Catalyst for Asymmetric Cyanoethoxycarbonylation
W. Wang, S. Gou, X. Liu, X. Feng*
Sichuan University, Chengdu, P. R. of China
Further Information
Publication History
Publication Date:
21 February 2008 (online)
Significance
The asymmetric cyanation of carbonyl compounds is an important reaction for the synthesis of versatile intermediates in organic synthesis. The development of a new efficient self-assembled titanium catalyst system for the asymmetric cyanoethoxycarbonylation of aldehydes is reported. Each component of the catalyst is commercially available or easily prepared. The corresponding products are obtained under mild conditions in moderate to good yields with good enantioselectivities (up to 99% yield and up to 94% ee). For previous work of this group with a tricomponent titanium catalyst using tertiary amines and BINOL derivatives as ligands, see: J. Org. Chem. 2006, 71, 5732.