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Thorac Cardiovasc Surg 2009; 57(2): 79-84
DOI: 10.1055/s-2008-1039209
Original Cardiovascular

© Georg Thieme Verlag KG Stuttgart · New York

Measurement of Myocardial Oxygen Tension: A Valid and Sensitive Method in the Investigation of Transmyocardial Laser Revascularization in an Acute Ischemia Model

M. C. Heidt1 , D. Sedding1 , S. K. H. Stracke1 , T. Stadlbauer1 , A. Boening2 , P. R. Vogt3 , M. Schönburg4
  • 1Department of Cardiology, University Clinic Giessen, Giessen, Germany
  • 2Department of Cardiovascular Surgery, University Clinic Giessen, Giessen, Germany
  • 3Department of Cardiovascular Surgery, Hirslanden Trust, Klinik im Park, Zurich, Switzerland
  • 4Department of Cardiovascular Surgery, Kerckhoff-Klinik, Bad Nauheim, Germany
Further Information

Publication History

received June 8, 2008

Publication Date:
24 February 2009 (online)

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Abstract

Background: The effect of transmyocardial laser revascularization (TMLR) on microperfusion and oxygen supply was studied in an acute ischemia model, using 35 pigs, with 13 serving as controls. Methods: Measurement of tissue oxygen tension was compared with the semiquantitative measurement of microperfusion using contrast echocardiography and infrared laser Doppler. All methods were used before and after coronary occlusion and after TMLR. Effects were measured in the ischemic area and in two ischemia independent areas. Results: At baseline, oxygen partial pressure was 54.2 ± 15.7 mmHg and decreased to 2.8 ± 1.4 mmHg (p < 0.05) after occlusion. After TMLR, oxygen tension increased to 27.3 ± 8.5 mmHg (p < 0.05) in the ischemic area, indicating a significant effect of TMLR on microperfusion and oxygen tension. Changes in regional oxygen tension corresponded to Levovist® density changes in contrast echocardiography and changes in microperfusion measured by infrared laser Doppler. Conclusions: Our data indicate that measurement of tissue oxygen tension is a suitable experimental tool to assess the effect of TMLR on myocardial perfusion, which cannot be discriminated using clinical imaging methods.

Key words

coronary bypass surgery - myocardial infarction - cardiovascular surgery

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Priv.-Doz. Dr. Martin Clemens Heidt

Department of Cardiology
University Clinic Giessen

Klinikstraße 36

35392 Giessen

Germany

Phone: + 49 64 19 94 21 12

Fax: + 49 64 19 94 43 76

Email: Martin.C.Heidt@innere.med.uni-giessen.de

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