RSS-Feed abonnieren
DOI: 10.1055/s-2008-1039061
© Georg Thieme Verlag KG Stuttgart · New York
Histological Changes in Neonatal Kidneys after Cardiopulmonary Bypass and Deep Hypothermic Circulatory Arrest[*]
Publikationsverlauf
received June 6, 2008
Publikationsdatum:
23. Januar 2009 (online)
![](https://www.thieme-connect.de/media/thoracic/200901/lookinside/thumbnails/10.1055-s-2008-1039061-1.jpg)
Abstract
Background: Renal failure after open-heart surgery is a serious complication resulting in increased mortality and morbidity. The aim of the study was to find out whether different strategies for open-heart surgery would result in renal histological differences in a neonatal animal model. Methods: The renal tissue of newborn piglets was examined after mild hypothermic cardiopulmonary bypass (CPB group; n = 10), deep hypothermic circulatory arrest (DHCA group; n = 8), instrumentation without extracorporeal circulation (sham; n = 3), and the data were compared with those of normal porcine neonatal kidneys (control; n = 6). The severity of tissue damage was graded using a 4-point scoring system (0: normal morphology, 3: severe damage). Apoptotic cells and granulocytes were counted. Results: The histological score was higher in all groups compared with controls (p < 0.05) and higher in the CPB group compared with the DHCA group (p < 0.05). More apoptotic cells and granulocytes were found in the CPB group compared with controls and the DHCA group (p < 0.05). Conclusions: Although changes in the kidney tissue of newborn piglets are detectable after any cardiac procedure, changes are more profound after cardiopulmonary bypass with mild hypothermia.
Key words
cardiovascular surgery - heart disease - myocardial protection
1 This study was presented at the 36th Annual Meeting of the German Society for Thoracic and Cardiovascular Surgery, February 11 – 14, 2 007, Hamburg, Germany
References
- 1 Zanardo G, Michielon P, Paccagnella A, Rosi P, Caló M, Salandin V, Da Ros A, Michieletto F, Simini G. Acute renal failure in the patient undergoing cardiac operation. J Thorac Cardiovasc Surg. 1994; 107 1489-1495
- 2 Baskin E, Saygili A, Harmanci K, Agras P I, Özdemir F N, Mercan S, Tokel K, Saatci U. Acute renal failure and mortality after open-heart surgery in infants. Ren Fail. 2005; 27 557-560
- 3 Bahar I, Akgul A, Ozatik M A, Vural K M, Demirbag A E, Boran M, Tasdemir O. Acute renal failure following open heart surgery: risk factors and prognosis. Perfusion. 2005; 20 317-322
- 4 Baxter P, Rigby M L, Jones O DH, Lincoln C, Shinebourne E A. Acute renal failure following cardiopulmonary bypass in children: results of treatment. Int J Cardiol. 1985; 7 235-239
- 5 Chan K L, Ip P, Chiu C S, Cheung Y F. Peritoneal dialysis after surgery for congenital heart disease in infants and young children. Ann Thorac Surg. 2003; 76 1443-1449
- 6 Dittrich S, Groneberg D A, von Loeper J, Lippek F, Hegemann O, Grosse-Siestrup C, Lange P E. Influence of cold storage on renal ischemia reperfusion injury after non-heart-beating donor explantation. Neprhon Exp Nephrol. 2004; 96 c97-c102
1 This study was presented at the 36th Annual Meeting of the German Society for Thoracic and Cardiovascular Surgery, February 11 – 14, 2 007, Hamburg, Germany
Dr. Theodor Tirilomis
Department of Thoracic, Cardiac, and Vascular Surgery
University of Göttingen
Robert-Koch-Straße 40
37075 Göttingen
Germany
Fax: + 49 5 51 39 60 02
eMail: theodor.tirilomis@med.uni-goettingen.de