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DOI: 10.1055/s-2008-1039060
© Georg Thieme Verlag KG Stuttgart · New York
Neutrophil Apoptosis by Fas/FasL: Harmful or Advantageous in Cardiac Surgery?
Publikationsverlauf
received June 19, 2008
Publikationsdatum:
23. Januar 2009 (online)
![](https://www.thieme-connect.de/media/thoracic/200901/lookinside/thumbnails/10.1055-s-2008-1039060-1.jpg)
Abstract
Polymorphonuclear leukocytes or neutrophils are the main executors of cellular death, both in septic inflammation during bacterial infection and in sterile inflammation during trauma or surgery. Whereas in septic inflammation neutrophils perform a useful function to fortify the host's defense against infection, in sterile inflammation, by contrast, they contribute to unwelcome tissue damage. Regardless of the situation, activated neutrophils exhibit a prolonged lifespan and delayed apoptotic death which, under normal conditions, is a prerequisite for their natural renewal. Traditionally, delayed neutrophil apoptosis was considered to promote trauma or surgical injury. According to the results of recent studies, however surprising they may appear, the reverse might be in keeping with what happens in vivo. Apoptotic signaling in neutrophils could, by contrast, contribute to intrinsic protection of the host's tissues. This review article, aimed preferentially but not exclusively at the cardiac surgeon, presents some new information in support of this viewpoint, which fits in with our own observations.
Key words
cardiovascular surgery - coronary bypass surgery - heart disease
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Prof. Jan Krejsek
Charles University in Prague, School of Medicine in Hradec Kralove
Department of Clinical Immunology and Allergology University Hospital
Sokolska St. 581
500 05 Hradec Kralove
Czech Republic
Fax: + 42 04 95 83 20 15
eMail: krejsek@fnhk.cz