Planta Med 2008; 74(3): 287-289
DOI: 10.1055/s-2008-1034309
Natural Products Chemistry
Letter
© Georg Thieme Verlag KG Stuttgart · New York

A Norsesquiterpene Lactone and a Benzoic Acid Derivative from the Leaves of Cyclocarya paliurus and their Glucosidase and Glycogen Phosphorylase Inhibiting Activities

Jun Li1 , 2 , Yuanyuan Lu2 , Xiaojian Su2 , Fu Li2 , Zhigang She1 , Xingcun He2 , Yongcheng Lin1
  • 1School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, P. R. China
  • 2School of Environment & Resources, Guangxi Normal University, Guilin, P. R. China
Further Information

Publication History

Received: October 30, 2007 Revised: January 7, 2008

Accepted: January 14, 2008

Publication Date:
26 February 2008 (online)

Abstract

Two novel compounds, 3-methoxypterolactone (1) and 2-amino-3,4-dihydroxy-5-methoxybenzoic acid (2), were isolated from leaves of Cyclocarya paliurus (Batal.) Iljinsk, together with nine known compounds: pterolactone (3), gallic acid (4), 4-hydroxy-3-methoxybenzoic acid (5), oleanolic acid (6), β-boswellic acid (7), α-boswellic acid (8), β-amyrin (9), β-amyrone (10) and 3β-O-trans-caffeoyl-morolic acid (11). The structure elucidation was based on spectroscopic methods, including two-dimensional NMR experiments (1H-1H COSY, HMQC and HMBC). All isolated compounds were evaluated for their glycosidase and glycogen phosphorylase inhibitory activities. 2-Amino-3,4-dihydroxy-5-methoxybenzoic acid and gallic acid showed significant α-glucosidase and glycogen phosphorylase inhibitory activities.

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Prof. Dr. Yongcheng Lin
Dr. Zhigang She

School of Chemistry and Chemical Engineering

Sun Yat-sen University

Guangzhou 510275

People’s Republic of China

Phone: +86-20-8403-9623

Fax: +86-20-8403-9623

Email: ceslyc@mail.sysu.edu.cn

Email: cesshzhg@mail.sysu.edu.cn