Z Gastroenterol 2008; 46(9): 1094-1146
DOI: 10.1055/s-2008-1027796
Leitlinie

© Georg Thieme Verlag KG Stuttgart · New York

S3-Leitlinie „Diagnostik und Therapie des Morbus Crohn”

Clinical Practice Guideline on Diagnosis and Treatment of Crohn's Disease Results of a German Evidence-based Consensus ConferenceJ. C. Hoffmann1 [*] , [**] 1 , J. C. Preiß2 [**] 1 , F. Autschbach3 , H. J. Buhr4 , W. Häuser5 , K. Herrlinger6 , W. Höhne2 , S. Koletzko7 , C. F. Krieglstein8 , W. Kruis9 , H. Matthes10 , G. Moser11 , M. Reinshagen12 , G. Rogler13 , S. Schreiber14 , A. G. Schreyer15 , B. Sido16 , B. Siegmund2 , A. Stallmach17 , B. Bokemeyer18 [*] 1 , E. F. Stange6 [*] 1 , M. Zeitz2 [*] 1
  • 1Medizinische Klinik I, St. Marienkrankenhaus, Ludwigshafen
  • 2Medizinische Klinik I, Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin
  • 3Pathologisches Institut, Universitätsklinikum Heidelberg
  • 4Chirurgische Klinik I, Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin
  • 5Klinik Innere Medizin I, Klinikum Saarbrücken
  • 6Abteilung für Innere Medizin 1 Schwerpunkte Gastroenterologie, Hepatologie und Endokrinologie, Robert-Bosch-Krankenhaus, Stuttgart
  • 7Abteilung für Gastroenterologie und Hepatologie, Dr.-von-Haunersches-Kinderspital der Ludwig-Maximilian-Universität München
  • 8Chirurgische Klinik, St.-Elisabeth-Krankenhaus Köln-Hohenlind
  • 9Abteilung für Innere Medizin, Evangelisches Krankenhaus Kalk, Köln
  • 10Abteilung für Innere Medizin, Gastroenterologie und Onkologie, Gemeinschaftskrankenhaus Havelhöhe, Berlin
  • 11Universitätsklinik für Innere Medizin III, Medizinische Universität Wien
  • 12Medizinische Klinik I, Klinikum Braunschweig
  • 13Department für Innere Medizin, Klinik für Gastroenterologie und Hepatologie, Universitätsspital Zürich
  • 14I. Medizinische Klinik, Institut für klinische Molekularbiologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel
  • 15Institut für Röntgendiagnostik, Klinikum der Universität Regensburg
  • 16Klinik für Allgemein- und Viszeralchirurgie, Krankenhaus Barmherzige Brüder Regensburg
  • 17Klinik für Innere Medizin II, Abteilung Gastroenterologie/Hepatologie/Infektiologie/Interdisziplinäre Endoskopie, Universitätsklinikum Jena
  • 18Gastroenterologische Gemeinschaftspraxis Minden
Further Information

Publication History

Publication Date:
22 September 2008 (online)

Tab. 1 Teilnehmer der Konsensuskonferenz, Arbeitsgruppen. I. Klinische Diagnostik – Vorsitz: K. Herrlinger (Stuttgart), A. G. Schreyer (Regensburg) S. Koletzko (München), D. Ludwig (Lübeck), M. Ratzlaff (DCCV, Nürtingen), C. Schmidt (Bonn), H. J. Schulz (Berlin) II. Pathologie – Vorsitz: F. Autschbach (Heidelberg) B. Siegmund (Berlin), M. Vieth (Bayreuth), J. Weismüller (Koblenz), C. Wittekind (Leipzig) III. Akuter Schub, steroidrefraktärer Verlauf, Ernährungstherapie – Vorsitz: A. Stallmach (Jena), S. Schreiber (Kiel) R. Behrens (Nürnberg), B. Kaltz (DCCV, Bremen), B. Klump (Stuttgart), S. Nikolaus (Kiel), H. Lochs (Berlin), J. Stein (Frankfurt), E. F. Stange (Stuttgart) IV. Remissionserhaltung, steroidabhängiger Verlauf – Vorsitz: G. Rogler (Zürich), W. Kruis (Köln) B. Bokemeyer (Minden), A. Dignaß (Frankfurt), J. C. Hoffmann (Ludwigshafen), K. M. Keller (Wiesbaden), T. Kucharzik (Lüneburg), D. Lümmen (DCCV, Berlin) V. Chirurgie, Fisteln – Vorsitz: C. F. Krieglstein (Köln), H. J. Buhr (Berlin) E. C. Jehle (Ravensburg), A. J. Kroesen (Köln), B. Sido (Regensburg), M. Zeitz (Berlin) VI. Extraintestinale Manifestation und assoziierte Erkrankungen – Vorsitz: M. Reinshagen (Braunschweig) R. Duchmann (Berlin), U. Fölsch (Kiel), R. Raedsch (Wiesbaden), G. v. Boyen (Ulm) VII. Psychosomatik, komplementäre Therapie – Vorsitz: G. Moser (Wien) W. Häuser (Saarbrücken), G. Jantschek (Lübeck), B. Küppers (Mannheim), J. Langhorst (Essen), H. Matthes (Berlin) VIII. Methodik und Zentrale W. Höhne (Berlin), T. Karge (Berlin)

Inhaltsverzeichnis Seite Teil I Einführung, Methodik, Definitionen 1095 Vorbemerkungen 1095 Ziele der Leitlinie, Gültigkeitsdauer 1096 Methodik 1096 Organisatorischer Ablauf des Konsensusprozesses 1096 Klassifikation der Evidenzklassen, Anwendbarkeit, Konsens, Empfehlungsgrade 1097 Definitionen 1098 Teil II Diagnostik 1099 1. Klinische Diagnostik 1099 Diagnosestellung 1099 Etablierung der Diagnose 1100 Dünndarmdiagnostik 1101 Untersuchungen im Verlauf 1102 Besondere Untersuchungssituationen 1103 Nicht empfohlene Untersuchungen 1103 2. Pathomorphologische Diagnostik 1103 Histopathologische Diagnostik an endoskopischen Biopsien 1103 Pathomorphologische Diagnostik an Operationspräparaten 1105 Histopathologische Diagnostik von intraepithelialen Neoplasien (IEN) 1105 Teil III Therapie 1106 3. Akuter Schub 1106 Einführung 1106 Morbus Crohn mit Ileozökalbefall 1106 Colitis Crohn 1107 Ausgedehnter Dünndarmbefall 1108 Befall des Ösophagus und Magens 1108 Steroidrefraktärer Verlauf 1109 Frührezidiv 1109 Rezidiv nach steroidabhängigem Verlauf 1110 Kinder und Jugendliche 1110 4. Remissionserhaltung 1111 Ziel der Langzeittherapie 1111 Indikation zur remissionserhaltenden Therapie bei Morbus Crohn 1111 Postoperative Remissionserhaltung 1113 Kinder und Jugendliche 1113 5. Medikamente 1113 Budesonid 1113 Systemisch wirksame Steroide 1114 Sulfasalazin 1114 Azathioprin/ 6-Mercaptopurin 1114 Methotrexat 1114 Anti-TNF-α-Antikörper 1114 6. Fertilität und Schwangerschaft 1115 Fertilität 1115 Schwangerschaft 1115 Medikamente in der Stillzeit 1116 7. Schmerztherapie 1116 8. Chirurgie bei Morbus Crohn 1117 Dünndarm oder ileokolische Erkrankung 1118 Morbus Crohn des Kolons 1119 Chirurgie und Medikation 1119 9. Diagnose und Management des fistulierenden Morbus Crohn 1120 Diagnostik von anorektalen und perianalen Fisteln 1120 Behandlung von Fisteln 1121 Teil IV Extraintestinale Manifestationen, Psychosomatik und komplementäre und alternative Therapien 1123 10. Extraintestinale Manifestationen 1123 Gelenkmanifestationen 1124 Osteoporose 1125 Hautmanifestationen 1125 Augenmanifestationen 1126 Hepatobiliäre Erkrankungen 1126 Seltene extraintestinale Manifestationen bei Morbus Crohn 1126 11. Psychosomatik 1126 Krankheitsverlauf beeinflussende psychosoziale Faktoren 1127 Therapeutische Ansätze 1127 Kinder und Jugendliche 1129 12. Komplementäre und alternative Therapien 1129 Definition 1130 Methodik 1130 Anwendung und Prävalenz 1130 Alternative Therapieverfahren 1131 Komplementärmedizinische Verfahren 1131 Danksagung 1132 Literatur 1132

Literatur

  • 1 Shivananda S, Lennard-Jones J, Logan R. et al . Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European Collaborative Study on Inflammatory Bowel Disease (EC-IBD).  Gut. 1996;  39 690-697
  • 2 Timmer A, Breuer-Katschinski B, Goebell H. Time trends in the incidence and disease location of Crohn’s disease 1980 – 1995: a prospective analysis in an urban population in Germany.  Inflamm Bowel Dis. 1999;  5 79-84
  • 3 Vind I, Riis L, Jess T. et al . Increasing incidences of inflammatory bowel disease and decreasing surgery rates in Copenhagen City and County, 2003 – 2005: a population-based study from the Danish Crohn colitis database.  Am J Gastroenterol. 2006;  101 1274-1282
  • 4 Rosch M, Leidl R, Tirpitz C. et al . Cost measurement based on a cost diary in patients with inflammatory bowel disease.  Z Gastroenterol. 2002;  40 217-228
  • 5 Stange E F, Schreiber S, Folsch U R. et al . Diagnostik und Therapie des Morbus Crohn: Ergebnisse einer evidenzbasierten Konsensuskonfrenz der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten.  Z Gastroenterol. 2003;  41 19-20
  • 6 Stange E F, Travis S P, Vermeire S. et al . European evidence based consensus on the diagnosis and management of Crohn’s disease: definitions and diagnosis.  Gut. 2006;  55 (Suppl 1) i1-i15
  • 7 Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften, Ärztliche Zentralstelle für Qualitätssicherung . Das Leitlinien-Manual.  Z Ärztl Fortbild Qualitätssich. 2001;  95 (Suppl 1) 1-84
  • 8 Hoffmann J C, Zeitz M, Bischoff S C. et al . Diagnostik und Therapie der Colitis ulcerosa: Ergebnisse einer evidenzbasierten Konsensuskonferenz der Deutschen Gesellschaft für Verdauungs- und Stoffwechselerkrankungen zusammen mit dem Kompetenznetz chronisch entzündliche Darmerkrankungen.  Z Gastroenterol. 2004;  42 979-1042
  • 9 Phillips B, Ball C, Sackett D. et al .Oxford-Centre for Evidence Based Medicine – Levels of Evidence and Grades of Recommendation. Online im WWW. URL: http://wwwcebmnet/indexaspx?o= 1025. 2001
  • 10 Hyams J, Markowitz J, Otley A. et al . Evaluation of the pediatric crohn disease activity index: a prospective multicenter experience.  J Pediatr Gastroenterol Nutr. 2005;  41 416-421
  • 11 Sandborn W J, Feagan B G, Hanauer S B. et al . A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn’s disease.  Gastroenterology. 2002;  122 512-530
  • 12 Lennard-Jones J E, Shivananda S. Clinical uniformity of inflammatory bowel disease a presentation and during the first year of disease in the north and south of Europe. EC-IBD Study Group.  Eur J Gastroenterol Hepatol. 1997;  9 353-359
  • 13 Bridger S, Lee J C, Bjarnason I. et al . In siblings with similar genetic susceptibility for inflammatory bowel disease, smokers tend to develop Crohn’s disease and non-smokers develop ulcerative colitis.  Gut. 2002;  51 21-25
  • 14 Fine K D, Schiller L R. AGA technical review on the evaluation and management of chronic diarrhea.  Gastroenterology. 1999;  116 1464-1486
  • 15 Farmer R, Hawk W, Turnbull R. Clinical patterns in Crohn’s disease: a statistical study of 615 cases.  Gastroenterology. 1975;  68 627-635
  • 16 Szumera M, Landowski P, Kaminska B. et al . Bone mineral density in inflammatory bowel diseases in children.  Med Wieku Rozwoj. 2006;  10 445-451
  • 17 Andersson R E, Olaison G, Tysk C. et al . Appendectomy is followed by increased risk of Crohn’s disease.  Gastroenterology. 2003;  124 40-46
  • 18 IBD Working Group of the European Society for Paediatric Gastroenterology Hepatology and Nutrition . Inflammatory bowel disease in children and adolescents: recommendations for diagnosis – the Porto criteria.  J Pediatr Gastroenterol Nutr. 2005;  41 1-7
  • 19 Fagan E A, Dyck R F, Maton P N. et al . Serum levels of C-reactive protein in Crohn’s disease and ulcerative colitis.  Eur J Clin Invest. 1982;  12 351-359
  • 20 Vermeire S, Van Assche G, Rutgeerts P. C-reactive protein as a marker for inflammatory bowel disease.  Inflamm Bowel Dis. 2004;  10 661-665
  • 21 Solem C A, Loftus E V, Tremaine W J. et al . Correlation of C-reactive protein with clinical, endoscopic, histologic, and radiographic activity in inflammatory bowel disease.  Inflamm Bowel Dis. 2005;  11 707-712
  • 22 Mylonaki Jr M, Langmead L, Pantes A. et al . Enteric infection in relapse of inflammatory bowel disease: importance of microbiological examination of stool.  Eur J Gastroenterol Hepatol. 2004;  16 775-778
  • 23 Korczowski B, Szybist W. Serum procalcitonin and C-reactive protein in children with diarrhoea of various aetiologies.  Acta Paediatr. 2004;  93 169-173
  • 24 Herrlinger K R, Dittmann R, Weitz G. et al . Serum procalcitonin differentiates inflammatory bowel disease and self-limited colitis.  Inflamm Bowel Dis. 2004;  10 229-233
  • 25 Boirivant M, Leoni M, Tariciotti D. et al . The clinical significance of serum C reactive protein levels in Crohn’s disease. Results of a prospective longitudinal study.  J Clin Gastroenterol. 1988;  10 401-405
  • 26 Aadland E, Fagerhol M K. Faecal calprotectin: a marker of inflammation throughout the intestinal tract.  Eur J Gastroenterol Hepatol. 2002;  14 823-825
  • 27 Roseth A G, Aadland E, Jahnsen J. et al . Assessment of disease activity in ulcerative colitis by faecal calprotectin, a novel granulocyte marker protein.  Digestion. 1997;  58 176-180
  • 28 Roseth A G, Schmidt P N, Fagerhol M K. Correlation between faecal excretion of indium-111-labelled granulocytes and calprotectin, a granulocyte marker protein, in patients with inflammatory bowel disease.  Scand J Gastroenterol. 1999;  34 50-54
  • 29 Fine K D, Ogunji F, George J. et al . Utility of a rapid fecal latex agglutination test detecting the neutrophil protein, lactoferrin, for diagnosing inflammatory causes of chronic diarrhea.  Am J Gastroenterol. 1998;  93 1300-1305
  • 30 Kane S V, Sandborn W J, Rufo P A. et al . Fecal lactoferrin is a sensitive and specific marker in identifying intestinal inflammation.  Am J Gastroenterol. 2003;  98 1309-1314
  • 31 Jong N S, Leach S T, Day A S. Fecal S 100A12: a novel noninvasive marker in children with Crohn’s disease.  Inflamm Bowel Dis. 2006;  12 566-572
  • 32 Kaiser de T, Langhorst J, Wittkowski H. et al . Fecal S 100A12 as non-invasive marker distinguishing inflammatory bowel disease from irritable bowel syndrome.  Gut. 2007;  56 1706
  • 33 Roon A C, Karamountzos von L, Purkayastha S. et al . Diagnostic precision of fecal calprotectin for inflammatory bowel disease and colorectal malignancy.  Am J Gastroenterol. 2007;  102 803-813
  • 34 Pascu M, Roznowski A B, Muller H P. et al . Clinical relevance of transabdominal ultrasonography and magnetic resonance imaging in patients with inflammatory bowel disease of the terminal ileum and large bowel.  Inflamm Bowel Dis. 2004;  10 373-382
  • 35 Parente F, Greco S, Molteni M. et al . Role of early ultrasound in detecting inflammatory intestinal disorders and identifying their anatomical location within the bowel.  Aliment Pharmacol Ther. 2003;  18 1009-1016
  • 36 Maconi G, Sampietro G M, Parente F. et al . Contrast radiology, computed tomography and ultrasonography in detecting internal fistulas and intra-abdominal abscesses in Crohn’s disease: a prospective comparative study.  Am J Gastroenterol. 2003;  98 1545-1555
  • 37 Geboes K, Ectors N, D’Haens G. et al . Is ileoscopy with biopsy worthwhile in patients presenting with symptoms of inflammatory bowel disease?.  Am J Gastroenterol. 1998;  93 201-206
  • 38 Coremans G, Rutgeerts P, Geboes K. et al . The value of ileoscopy with biopsy in the diagnosis of intestinal Crohn’s disease.  Gastrointest Endosc. 1984;  30 167-172
  • 39 Morrin M, Raptopoulos V, Weisinger K. et al . Virtual Colonography: Techniques and Current Clinical Applications.  Surg Technol Int. 2000;  VIII 121-127
  • 40 Beall D P, Fortman B J, Lawler B C. et al . Imaging bowel obstruction: a comparison between fast magnetic resonance imaging and helical computed tomography.  Clin Radiol. 2002;  57 719-724
  • 41 Sawczenko A, Sandhu B K. Presenting features of inflammatory bowel disease in Great Britain and Ireland.  Arch Dis Child. 2003;  88 995-1000
  • 42 Castellaneta S P, Afzal N A, Greenberg M. et al . Diagnostic role of upper gastrointestinal endoscopy in pediatric inflammatory bowel disease.  J Pediatr Gastroenterol Nutr. 2004;  39 257-261
  • 43 Abdullah B A, Gupta S K, Croffie J M. et al . The role of esophagogastroduodenoscopy in the initial evaluation of childhood inflammatory bowel disease: a 7-year study.  J Pediatr Gastroenterol Nutr. 2002;  35 636-640
  • 44 Mashako M N, Cezard J P, Navarro J. et al . Crohn’s disease lesions in the upper gastrointestinal tract: correlation between clinical, radiological, endoscopic, and histological features in adolescents and children.  J Pediatr Gastroenterol Nutr. 1989;  8 442-446
  • 45 Elitsur Y, Blankenship P, Lawrence Z. Propofol sedation for endoscopic procedures in children.  Endoscopy. 2000;  32 788-791
  • 46 Wengrower D, Gozal D, Gozal Y. et al . Complicated endoscopic pediatric procedures using deep sedation and general anesthesia are safe in the endoscopy suite.  Scand J Gastroenterol. 2004;  39 283-286
  • 47 Lipson A, Bartram C I, Williams C B. et al . Barium studies and ileoscopy compared in children with suspected Crohn’s disease.  Clin Radiol. 1990;  41 5-8
  • 48 Halligan S, Nicholls S, Beattie R M. et al . The role of small bowel radiology in the diagnosis and management of Crohn’s disease.  Acta Paediatr. 1995;  84 1375-1378
  • 49 Alberini J L, Badran A, Freneaux E. et al . Technetium-99m HMPAO-labeled leukocyte imaging compared with endoscopy, ultrasonography, and contrast radiology in children with inflammatory bowel disease.  J Pediatr Gastroenterol Nutr. 2001;  32 278-286
  • 50 Bremner A R, Pridgeon J, Fairhurst J. et al . Ultrasound scanning may reduce the need for barium radiology in the assessment of small-bowel Crohn’s disease.  Acta Paediatr. 2004;  93 479-481
  • 51 Laghi A, Borrelli O, Paolantonio P. et al . Contrast enhanced magnetic resonance imaging of the terminal ileum in children with Crohn’s disease.  Gut. 2003;  52 393-397
  • 52 Darbari A, Sena L, Argani P. et al . Gadolinium-enhanced magnetic resonance imaging: a useful radiological tool in diagnosing pediatric IBD.  Inflamm Bowel Dis. 2004;  10 67-72
  • 53 Schmidt T, Hohl C, Haage P. et al . Phase-inversion tissue harmonic imaging compared to fundamental B-mode ultrasound in the evaluation of the pathology of large and small bowel.  Eur Radiol. 2005;  15 2021-2030
  • 54 Parente F, Greco S, Molteni M. et al . Oral contrast enhanced bowel ultrasonography in the assessment of small intestine Crohn’s disease. A prospective comparison with conventional ultrasound, × ray studies, and ileocolonoscopy.  Gut. 2004;  53 1652-1657
  • 55 Schreyer A G, Geissler A, Albrich H. et al . Abdominal MRI after enteroclysis or with oral contrast in patients with suspected or proven Crohn’s disease.  Clin Gastroenterol Hepatol. 2004;  2 491-497
  • 56 Schreyer A G, Seitz J, Feuerbach S. et al . Modern imaging using computer tomography and magnetic resonance imaging for inflammatory bowel disease (IBD) AU 1.  Inflamm Bowel Dis. 2004;  10 45-54
  • 57 Bernstein C N, Greenberg H, Boult I. et al . A prospective comparison study of MRI versus small bowel follow-through in recurrent Crohn’s disease.  Am J Gastroenterol. 2005;  100 2493-2502
  • 58 Potthast S, Rieber A, Von Tirpitz C. et al . Ultrasound and magnetic resonance imaging in Crohn’s disease: a comparison.  Eur Radiol. 2002;  12 1416-1422
  • 59 Ludwig D, Wiener S, Bruning A. et al . Mesenteric blood flow is related to disease activity and risk of relapse in Crohn’s disease: a prospective follow-up study.  Am J Gastroenterol. 1999;  94 2942-2950
  • 60 Homann N, Klarmann U, Fellermann K. et al . Mesenteric pulsatility index analysis predicts response to azathioprine in patients with Crohn’s disease.  Inflamm Bowel Dis. 2005;  11 126-132
  • 61 Heyne R, Rickes S, Bock P. et al . Non-invasive evaluation of activity in inflammatory bowel disease by power Doppler sonography.  Z Gastroenterol. 2002;  40 171-175
  • 62 Di Sabatino A, Fulle I, Ciccocioppo R. et al . Doppler enhancement after intravenous levovist injection in Crohn’s disease.  Inflamm Bowel Dis. 2002;  8 251-257
  • 63 Wagtmans M J, Verspaget H W, Lamers C B. et al . Clinical aspects of Crohn’s disease of the upper gastrointestinal tract: a comparison with distal Crohn’s disease.  Am J Gastroenterol. 1997;  92 1467-1471
  • 64 Rutgeerts P, Onette E, Vantrappen G. et al . Crohn’s disease of the stomach and duodenum: A clinical study with emphasis on the value of endoscopy and endoscopic biopsies.  Endoscopy. 1980;  12 288-294
  • 65 Albert J G, Martiny F, Krummenerl A. et al . Diagnosis of small bowel Crohn’s disease: a prospective comparison of capsule endoscopy with magnetic resonance imaging and fluoroscopic enteroclysis.  Gut. 2005;  54 1721-1727
  • 66 Golder S K, Schreyer A G, Endlicher E. et al . Comparison of capsule endoscopy and magnetic resonance (MR) enteroclysis in suspected small bowel disease.  Int J Colorectal Dis. 2006;  21 97-104
  • 67 Voderholzer W A, Beinhoelzl J, Rogalla P. et al . Small bowel involvement in Crohn’s disease: a prospective comparison of wireless capsule endoscopy and computed tomography enteroclysis.  Gut. 2005;  54 369-373
  • 68 Liangpunsakul S, Chadalawada V, Rex D K. et al . Wireless capsule endoscopy detects small bowel ulcers in patients with normal results from state of the art enteroclysis.  Am J Gastroenterol. 2003;  98 1295-1298
  • 69 Eliakim R, Fischer D, Suissa A. et al . Wireless capsule video endoscopy is a superior diagnostic tool in comparison to barium follow-through and computerized tomography in patients with suspected Crohn’s disease.  Eur J Gastroenterol Hepatol. 2003;  15 363-367
  • 70 Triester S L, Leighton J A, Leontiadis G I. et al . A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with non-stricturing small bowel Crohn’s disease.  Am J Gastroenterol. 2006;  101 954-964
  • 71 Graham D Y, Opekun A R, Willingham F F. et al . Visible small-intestinal mucosal injury in chronic NSAID users.  Clin Gastroenterol Hepatol. 2005;  3 55-59
  • 72 Goldstein J L, Eisen G M, Lewis B. et al . Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placebo.  Clin Gastroenterol Hepatol. 2005;  3 133-141
  • 73 Oshitani N, Yukawa T, Yamagami H. et al . Evaluation of deep small bowel involvement by double-balloon enteroscopy in Crohn’s disease.  Am J Gastroenterol. 2006;  101 1484-1489
  • 74 Geerling B J, Badart-Smook A, Stockbrugger R W. et al . Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls.  Eur J Clin Nutr. 2000;  54 514-521
  • 75 Filippi J, Al-Jaouni R, Wiroth J B. et al . Nutritional deficiencies in patients with Crohn’s disease in remission.  Inflamm Bowel Dis. 2006;  12 185-191
  • 76 Rodemann J F, Dubberke E R, Reske K A. et al . Incidence of Clostridium difficile infection in inflammatory bowel disease.  Clin Gastroenterol Hepatol. 2007;  5 339-344
  • 77 Issa M, Vijayapal A, Graham M B. et al . Impact of Clostridium difficile on inflammatory bowel disease.  Clin Gastroenterol Hepatol. 2007;  5 345-351
  • 78 Takahashi Y, Tange T. Prevalence of cytomegalovirus infection in inflammatory bowel disease patients.  Dis Colon Rectum. 2004;  47 722-726
  • 79 Dimitroulia E, Spanakis N, Konstantinidou A E. et al . Frequent detection of cytomegalovirus in the intestine of patients with inflammatory bowel disease.  Inflamm Bowel Dis. 2006;  12 879-884
  • 80 Cottone M, Pietrosi G, Martorana G. et al . Prevalence of cytomegalovirus infection in severe refractory ulcerative and Crohn’s colitis.  Am J Gastroenterol. 2001;  96 773-775
  • 81 Hommes D W, Sterringa G, Deventer S J. et al . The pathogenicity of cytomegalovirus in inflammatory bowel disease: a systematic review and evidence-based recommendations for future research.  Inflamm Bowel Dis. 2004;  10 245-250
  • 82 Eaden J A, Abrams K R, Mayberry J F. The risk of colorectal cancer in ulcerative colitis: a meta-analysis.  Gut. 2001;  48 526-535
  • 83 Jess van T, Gamborg M, Matzen P. et al . Increased risk of intestinal cancer in Crohn’s disease: a meta-analysis of population-based cohort studies.  Am J Gastroenterol. 2005;  100 2724-2729
  • 84 Jess T, Loftus E V, Velayos F S. et al . Risk of intestinal cancer in inflammatory bowel disease: a population-based study from olmsted county, Minnesota.  Gastroenterology. 2006;  130 1039-1046
  • 85 Bernstein C N, Blanchard J F, Kliewer Jr E. et al . Cancer risk in patients with inflammatory bowel disease: a population-based study.  Cancer. 2001;  91 854-862
  • 86 Hoffmann J C, Zeitz M, Bischoff S C. et al . Diagnosis and therapy of ulcerative colitis: results of an evidence based consensus conference by the German society of Digestive and Metabolic Diseases and the competence network on inflammatory bowel disease.  Z Gastroenterol. 2004;  42 979-983
  • 87 Ogura Y, Bonen D K, Inohara N. et al . A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease.  Nature. 2001;  411 603-606
  • 88 Hugot J P, Chamaillard M, Zouali H. et al . Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease.  Nature. 2001;  411 599-603
  • 89 Ahmad T, Armuzzi A, Bunce M. et al . The molecular classification of the clinical manifestations of Crohn’s disease.  Gastroenterology. 2002;  122 854-866
  • 90 Lesage S, Zouali H, Cezard J P. et al . CARD15 /NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease.  Am J Hum Genet. 2002;  70 845-857
  • 91 Radlmayr M, Torok H P, Martin K. et al . The c-insertion mutation of the NOD2 gene is associated with fistulizing and fibrostenotic phenotypes in Crohn’s disease.  Gastroenterology. 2002;  122 2091-2092
  • 92 Peeters M, Joossens S, Vermeire S. et al . Diagnostic value of anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease.  Am J Gastroenterol. 2001;  96 730-734
  • 93 Zholudev A, Zurakowski D, Young W. et al . Serologic testing with ANCA, ASCA, and anti-OmpC in children and young adults with Crohn’s disease and ulcerative colitis: diagnostic value and correlation with disease phenotype.  Am J Gastroenterol. 2004;  99 2235-2241
  • 94 Plevy S. Do serological markers and cytokines determine the indeterminate?.  J Clin Gastroenterol. 2004;  38 S51-56
  • 95 Hollander D, Vadheim C M, Brettholz E. et al . Increased intestinal permeability in patients with Crohn’s disease and their relatives. A possible etiologic factor.  Ann Intern Med. 1986;  105 883-885
  • 96 Wyatt J, Vogelsang H, Hubl W. et al . Intestinal permeability and the prediction of relapse in Crohn’s disease.  Lancet. 1993;  341 1437-1439
  • 97 Silverberg M S, Satsangi J, Ahmad T. et al . Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology.  Can J Gastroenterol. 2005;  19 (Suppl A) 5-36
  • 98 Allison M C, Hamilton-Dutoit S J, Dhillon A P. et al . The value of rectal biopsy in distinguishing self-limited colitis from early inflammatory bowel disease.  Q J Med. 1987;  65 985-995
  • 99 Bentley E, Jenkins D, Campbell F. et al . How could pathologists improve the initial diagnosis of colitis? Evidence from an international workshop.  J Clin Pathol. 2002;  55 955-960
  • 100 Dejaco C, Oesterreicher C, Angelberger S. et al . Diagnosing colitis: a prospective study on essential parameters for reaching a diagnosis.  Endoscopy. 2003;  35 1004-1008
  • 101 Dube A K, Cross S S, Lobo A J. Audit of the histopathological diagnosis of non-neoplastic colorectal biopsies: achievable standards for the diagnosis of inflammatory bowel disease.  J Clin Pathol. 1998;  51 378-381
  • 102 Dundas S A, Dutton J, Skipworth P. Reliability of rectal biopsy in distinguishing between chronic inflammatory bowel disease and acute self-limiting colitis.  Histopathology. 1997;  31 60-66
  • 103 Jenkins D, Balsitis M, Gallivan S. et al . Guidelines for the initial biopsy diagnosis of suspected chronic idiopathic inflammatory bowel disease. The British Society of Gastroenterology Initiative.  J Clin Pathol. 1997;  50 93-105
  • 104 Nostrant T T, Kumar N B, Appelman H D. Histopathology differentiates acute self-limited colitis from ulcerative colitis.  Gastroenterology. 1987;  92 318-328
  • 105 Schumacher G, Kollberg B, Sandstedt B. A prospective study of first attacks of inflammatory bowel disease and infectious colitis. Histologic course during the 1st year after presentation.  Scand J Gastroenterol. 1994;  29 318-332
  • 106 Seldenrijk C A, Morson B C, Meuwissen S G. et al . Histopathological evaluation of colonic mucosal biopsy specimens in chronic inflammatory bowel disease: diagnostic implications.  Gut. 1991;  32 1514-1520
  • 107 Surawicz C M, Belic L. Rectal biopsy helps to distinguish acute self-limited colitis from idiopathic inflammatory bowel disease.  Gastroenterology. 1984;  86 104-113
  • 108 Tanaka M, Masuda T, Yao T. et al . Observer variation of diagnoses based on simple biopsy criteria differentiating among Crohn’s disease, ulcerative colitis, and other forms of colitis.  J Gastroenterol Hepatol. 2001;  16 1368-1372
  • 109 Tanaka M, Riddell R H, Saito H. et al . Morphologic criteria applicable to biopsy specimens for effective distinction of inflammatory bowel disease from other forms of colitis and of Crohn’s disease from ulcerative colitis.  Scand J Gastroenterol. 1999;  34 55-67
  • 110 Tanaka M, Saito H, Fukuda S. et al . Simple mucosal biopsy criteria differentiating among Crohn disease, ulcerative colitis, and other forms of colitis: measurement of validity.  Scand J Gastroenterol. 2000;  35 281-286
  • 111 Theodossi A, Spiegelhalter D J, Jass J. et al . Observer variation and discriminatory value of biopsy features in inflammatory bowel disease.  Gut. 1994;  35 961-968
  • 112 Mahadeva U, Martin J P, Patel N K. et al . Granulomatous ulcerative colitis: a re-appraisal of the mucosal granuloma in the distinction of Crohn’s disease from ulcerative colitis.  Histopathology. 2002;  41 50-55
  • 113 Schmitz-Moormann P, Pittner P M, Malchow H. et al . The granuloma in Crohn’s disease. A bioptical study.  Pathol Res Pract. 1984;  178 467-476
  • 114 Cherian S, Singh P. Is routine ileoscopy useful? An observational study of procedure times, diagnostic yield, and learning curve.  Am J Gastroenterol. 2004;  99 2324-2329
  • 115 Surawicz C M. Serial sectioning of a portion of a rectal biopsy detects more focal abnormalities: a prospective study of patients with inflammatory bowel disease.  Dig Dis Sci. 1982;  27 434-436
  • 116 Surawicz C M, Meisel J L, Ylvisaker T. et al . Rectal biopsy in the diagnosis of Crohn’s disease: value of multiple biopsies and serial sectioning.  Gastroenterology. 1981;  80 66-71
  • 117 Geboes K, Dalle I. Influence of treatment on morphological features of mucosal inflammation.  Gut. 2002;  50 (Suppl 3) III37-III42
  • 118 Odze R, Antonioli D, Peppercorn M. et al . Effect of topical 5-aminosalicylic acid (5-ASA) therapy on rectal mucosal biopsy morphology in chronic ulcerative colitis.  Am J Surg Pathol. 1993;  17 869-875
  • 119 Kleer C G, Appelman H D. Ulcerative colitis: patterns of involvement in colorectal biopsies and changes with time.  Am J Surg Pathol. 1998;  22 983-989
  • 120 Bousvaros A, Antonioli D A, Colletti R B. et al . Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn’s and Colitis Foundation of America.  J Pediatr Gastroenterol Nutr. 2007;  44 653-674
  • 121 Glickman J N, Bousvaros A, Farraye F A. et al . Pediatric patients with untreated ulcerative colitis may present initially with unusual morphologic findings.  Am J Surg Pathol. 2004;  28 190-197
  • 122 Robert M E, Tang L, Hao L M. et al . Patterns of inflammation in mucosal biopsies of ulcerative colitis: perceived differences in pediatric populations are limited to children younger than 10 years.  Am J Surg Pathol. 2004;  28 183-189
  • 123 Autschbach F. Pathologie der CED. Hoffmann JC, Krösen AJ, Klump B Chronisch entzündliche Darmerkrankungen Das CED-Handbuch für Klinik und Praxis Stuttgart; Thieme 2004: 110-122
  • 124 Borchard F. Differential diagnosis of colitis.  Verh Dtsch Ges Pathol. 1999;  83 110-121
  • 125 Herbay von A. Histopathologische Diagnostik chronischentzündlicher Darmerkrankungen. Historischer Rückblick und aktuelle Übersicht.  Pathologe. 1999;  20 276-287
  • 126 Lemberg D A, Clarkson C M, Bohane T D. et al . Role of esophagogastroduodenoscopy in the initial assessment of children with inflammatory bowel disease.  J Gastroenterol Hepatol. 2005;  20 1696-1700
  • 127 Oberhuber G, Hirsch M, Stolte M. High incidence of upper gastrointestinal tract involvement in Crohn’s disease.  Virchows Arch. 1998;  432 49-52
  • 128 Oberhuber G, Puspok A, Oesterreicher C. et al . Focally enhanced gastritis: a frequent type of gastritis in patients with Crohn’s disease.  Gastroenterology. 1997;  112 698-706
  • 129 Parente F, Cucino C, Bollani S. et al . Focal gastric inflammatory infiltrates in inflammatory bowel diseases: prevalence, immunohistochemical characteristics, and diagnostic role.  Am J Gastroenterol. 2000;  95 705-711
  • 130 Sharif F, McDermott M, Dillon M. et al . Focally enhanced gastritis in children with Crohn’s disease and ulcerative colitis.  Am J Gastroenterol. 2002;  97 1415-1420
  • 131 Gomes P, du Boulay C, Smith C L. et al . Relationship between disease activity indices and colonoscopic findings in patients with colonic inflammatory bowel disease.  Gut. 1986;  27 92-95
  • 132 D’Haens G, Van Deventer S, Van Hogezand R. et al . Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn’s disease: A European multicenter trial.  Gastroenterology. 1999;  116 1029-1034
  • 133 Riley S A, Mani V, Goodman M J. et al . Microscopic activity in ulcerative colitis: what does it mean?.  Gut. 1991;  32 174-178
  • 134 Cook M G, Dixon M F. An analysis of the reliability of detection and diagnostic value of various pathological features in Crohn’s disease and ulcerative colitis.  Gut. 1973;  14 255-262
  • 135 Hamilton S R. Diagnosis and comparison of ulcerative colitis and Crohn’s disease involving the colon. Norris HT Pathology of the colon, small intestine, and anus New York; Churchill Livingstone 1991: 1-22
  • 136 Price A B, Morson B C. Inflammatory bowel disease: the surgical pathology of Crohn’s disease and ulcerative colitis.  Hum Pathol. 1975;  6 7-29
  • 137 Sheehan A L, Warren B F, Gear M W. et al . Fat-wrapping in Crohn’s disease: pathological basis and relevance to surgical practice.  Br J Surg. 1992;  79 955-958
  • 138 Canavan C, Abrams K R, Mayberry J. Meta-analysis: colorectal and small bowel cancer risk in patients with Crohn’s disease.  Aliment Pharmacol Ther. 2006;  23 1097-1104
  • 139 Collins P D, Mpofu C, Watson A J. et al . Strategies for detecting colon cancer and/or dysplasia in patients with inflammatory bowel disease.  Cochrane Database Syst Rev. 2006;  CD000279
  • 140 Ekbom A, Helmick C, Zack M. et al . Increased risk of large-bowel cancer in Crohn’s disease with colonic involvement.  Lancet. 1990;  336 357-359
  • 141 Maykel J A, Hagerman G, Mellgren A F. et al . Crohn’s colitis: the incidence of dysplasia and adenocarcinoma in surgical patients.  Dis Colon Rectum. 2006;  49 950-957
  • 142 Riddell R H, Goldman H, Ransohoff D F. et al . Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications.  Hum Pathol. 1983;  14 931-968
  • 143 Choi P M, Zelig M P. Similarity of colorectal cancer in Crohn’s disease and ulcerative colitis: implications for carcinogenesis and prevention.  Gut. 1994;  35 950-954
  • 144 Svrcek M, Cosnes J, Beaugerie L. et al . Colorectal neoplasia in Crohn’s colitis: a retrospective comparative study with ulcerative colitis.  Histopathology. 2007;  50 574-583
  • 145 Hamilton S R, Vogelstein B, Kudo S. Carcinoma of the colon and rectum. Hamilton SR, Aaltonen LA World Health Organization Classification of Tumors Pathology and Genetics of Tumors of the Digestive System Lyon; IARC Press 2000
  • 146 Schlemper R J, Riddell R H, Kato Y. et al . The Vienna classification of gastrointestinal epithelial neoplasia.  Gut. 2000;  47 251-255
  • 147 Rubin C E, Haggitt R C, Burmer G C. et al . DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis.  Gastroenterology. 1992;  103 1611-1620
  • 148 Kiesslich R, Fritsch J, Holtmann M. et al . Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis.  Gastroenterology. 2003;  124 880-888
  • 149 Rutter M D, Saunders B P, Schofield G. et al . Pancolonic indigo carmine dye spraying for the detection of dysplasia in ulcerative colitis.  Gut. 2004;  53 256-260
  • 150 Blackstone M O, Riddell R H, Rogers B H. et al . Dysplasia-associated lesion or mass (DALM) detected by colonoscopy in long-standing ulcerative colitis: an indication for colectomy.  Gastroenterology. 1981;  80 366-374
  • 151 Bernstein C N, Shanahan F, Weinstein W M. Are we telling patients the truth about surveillance colonoscopy in ulcerative colitis?.  Lancet. 1994;  343 71-74
  • 152 Engelsgjerd M, Farraye F A, Odze R D. Polypectomy may be adequate treatment for adenoma-like dysplastic lesions in chronic ulcerative colitis.  Gastroenterology. 1999;  117 1288-1294; discussion 1488 – 1291
  • 153 Rubin P H, Friedman S, Harpaz N. et al . Colonoscopic polypectomy in chronic colitis: conservative management after endoscopic resection of dysplastic polyps.  Gastroenterology. 1999;  117 1295-1300
  • 154 Torres C, Antonioli D, Odze R D. Polypoid dysplasia and adenomas in inflammatory bowel disease: a clinical, pathologic, and follow-up study of 89 polyps from 59 patients.  Am J Surg Pathol. 1998;  22 275-284
  • 155 Vieth M, Behrens H, Stolte M. Sporadic adenoma in ulcerative colitis: endoscopic resection is an adequate treatment.  Gut. 2006;  55 1151-1155
  • 156 Schneider A, Stolte M. Differential diagnosis of adenomas and dysplastic lesions in patients with ulcerative colitis.  Z Gastroenterol. 1993;  31 653-656
  • 157 Befrits R, Ljung T, Jaramillo E. et al . Low-grade dysplasia in extensive, long-standing inflammatory bowel disease: a follow-up study.  Dis Colon Rectum. 2002;  45 615-620
  • 158 Jess T, Loftus E V, Velayos F S. et al . Incidence and prognosis of colorectal dysplasia in inflammatory bowel disease: a population-based study from Olmsted County, Minnesota.  Inflamm Bowel Dis. 2006;  12 669-676
  • 159 Lim C H, Dixon M F, Vail Jr A. et al . Ten year follow up of ulcerative colitis patients with and without low grade dysplasia.  Gut. 2003;  52 1127-1132
  • 160 Ullman T, Croog V, Harpaz N. et al . Progression of flat low-grade dysplasia to advanced neoplasia in patients with ulcerative colitis.  Gastroenterology. 2003;  125 1311-1319
  • 161 Eaden J, Abrams K, McKay H. et al . Inter-observer variation between general and specialist gastrointestinal pathologists when grading dysplasia in ulcerative colitis.  J Pathol. 2001;  194 152-157
  • 162 Jeejeebhoy K N, Detsky A S, Baker J P. Assessment of nutritional status.  JPEN J Parenter Enteral Nutr. 1990;  14 193S-196S
  • 163 Lochs H, Dejong C, Hammarqvist F. et al . ESPEN Guidelines on Enteral Nutrition: Gastroenterology.  Clin Nutr. 2006;  25 260-274
  • 164 Otley A, Steinhart A H. Budesonide for induction of remission in Crohn’s disease.  Cochrane Database Syst Rev. 2005;  CD000296
  • 165 Bar-Meir S, Chowers Y, Lavy A. et al . Budesonide versus prednisone in the treatment of active Crohn’s disease. The Israeli Budesonide Study Group.  Gastroenterology. 1998;  115 835-840
  • 166 Caesar I, Gross V, Roth M. et al . Treatment of active and postactive ileal and colonic Crohn’s disease with oral pH-modified-release budesonide. German Budesonide Study Group.  Hepatogastroenterology. 1997;  44 445-451
  • 167 Campieri M, Ferguson A, Doe W. et al . Oral budesonide is as effective as oral prednisolone in active Crohn’s disease. The Global Budesonide Study Group.  Gut. 1997;  41 209-214
  • 168 Escher J C. Budesonide versus prednisolone for the treatment of active Crohn’s disease in children: a randomized, double-blind, controlled, multicentre trial.  Eur J Gastroenterol Hepatol. 2004;  16 47-54
  • 169 Greenberg G R, Feagan B G, Martin F. et al . Oral budesonide for active Crohn’s disease. Canadian Inflammatory Bowel Disease Study Group.  N Engl J Med. 1994;  331 836-841
  • 170 Gross V, Andus T, Caesar I. et al . Oral pH-modified release budesonide versus 6-methylprednisolone in active Crohn’s disease. German/Austrian Budesonide Study Group.  Eur J Gastroenterol Hepatol. 1996;  8 905-909
  • 171 Hanauer S B, Stromberg U. Oral Pentasa in the treatment of active Crohn’s disease: A meta-analysis of double-blind, placebo-controlled trials.  Clin Gastroenterol Hepatol. 2004;  2 379-388
  • 172 Su C. Outcomes of placebo therapy in inflammatory bowel disease.  Inflamm Bowel Dis. 2006;  12 328-333
  • 173 Prantera C, Lochs H, Campieri M. et al . Antibiotic treatment of Crohn’s disease: results of a multicentre, double blind, randomized, placebo-controlled trial with rifaximin.  Aliment Pharmacol Ther. 2006;  23 1117-1125
  • 174 Colombel J F, Lemann M, Cassagnou M. et al . A controlled trial comparing ciprofloxacin with mesalazine for the treatment of active Crohn’s disease. Groupe d’Etudes Therapeutiques des Affections Inflammatoires Digestives (GETAID).  Am J Gastroenterol. 1999;  94 674-678
  • 175 Goodgame R W, Kimball K, Akram S. et al . Randomized controlled trial of clarithromycin and ethambutol in the treatment of Crohn’s disease.  Aliment Pharmacol Ther. 2001;  15 1861-1866
  • 176 Sutherland L, Singleton J, Sessions J. et al . Double blind, placebo controlled trial of metronidazole in Crohn’s disease.  Gut. 1991;  32 1071-1075
  • 177 Ambrose N S, Allan R N, Keighley M R. et al . Antibiotic therapy for treatment in relapse of intestinal Crohn’s disease. A prospective randomized study.  Dis Colon Rectum. 1985;  28 81-85
  • 178 Blichfeldt P, Blomhoff J P, Myhre E. et al . Metronidazole in Crohn’s disease. A double blind cross-over clinical trial.  Scand J Gastroenterol. 1978;  13 123-127
  • 179 Arnold G L, Beaves M R, Pryjdun V O. et al . Preliminary study of ciprofloxacin in active Crohn’s disease.  Inflamm Bowel Dis. 2002;  8 10-15
  • 180 Prantera C, Zannoni F, Scribano M L. et al . An antibiotic regimen for the treatment of active Crohn’s disease: a randomized, controlled clinical trial of metronidazole plus ciprofloxacin.  Am J Gastroenterol. 1996;  91 328-332
  • 181 Selby W, Pavli P, Crotty B. et al . Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn’s disease.  Gastroenterology. 2007;  132 2313-2319
  • 182 Modigliani R, Mary J Y, Simon J F. et al . Clinical, biological, and endoscopic picture of attacks of Crohn’s disease. Evolution on prednisolone. Groupe d’Etude Therapeutique des Affections Inflammatoires Digestives.  Gastroenterology. 1990;  98 811-818
  • 183 Benchimol E, Seow C, Steinhart A. et al . Traditional corticosteroids for induction of remission in Crohn’s disease.  Cochrane Database Syst Rev. 2008;  CD006792
  • 184 Zachos M, Tondeur M, Griffiths A M. Enteral nutritional therapy for induction of remission in Crohn’s disease.  Cochrane Database Syst Rev. 2007;  CD000542
  • 185 Lochs H, Steinhardt H J, Klaus-Wentz B. et al . Comparison of enteral nutrition and drug treatment in active Crohn’s disease. Results of the European Cooperative Crohn’s Disease Study. IV.  Gastroenterology. 1991;  101 881-888
  • 186 Schutz T, Valentini L, Herbst B. et al . ESPEN guidelines on enteral nutrition – summary.  Z Gastroenterol. 2006;  44 683-684
  • 187 Gasche C, Berstad A, Befrits R. et al . Guidelines on the diagnosis and management of iron deficiency and anemia in inflammatory bowel diseases.  Inflamm Bowel Dis. 2007;  13 1545-1553
  • 188 Steinhart A H, Feagan B G, Wong C J. et al . Combined budesonide and antibiotic therapy for active Crohn’s disease: a randomized controlled trial.  Gastroenterology. 2002;  123 33-40
  • 189 Summers R W, Switz D M, Sessions J T. et al . National Cooperative Crohn’s Disease Study: results of drug treatment.  Gastroenterology. 1979;  77 847-869
  • 190 Malchow Jr H, Ewe K, Brandes J W. et al . European Cooperative Crohn’s Disease Study (ECCDS): results of drug treatment.  Gastroenterology. 1984;  86 249-266
  • 191 Mielants H, Veys E M, Cuvelier C. et al . HLA-B27 related arthritis and bowel inflammation. Part 2. Ileocolonoscopy and bowel histology in patients with HLA-B27 related arthritis.  J Rheumatol. 1985;  12 294-298
  • 192 Herfarth H, Gross V, Andus T. et al . Analysis of the therapeutic efficacy of different doses of budesonide in patients with active Crohn’s ileocolitis depending on disease activity and localization.  Int J Colorectal Dis. 2004;  19 147-152
  • 193 Beaugerie L, Seksik P, Nion-Larmurier I. et al . Predictors of Crohn’s disease.  Gastroenterology. 2006;  130 650-656
  • 194 Fichera A, Lovadina S, Rubin M. et al . Patterns and operative treatment of recurrent Crohn’s disease: a prospective longitudinal study.  Surgery. 2006;  140 649-654
  • 195 Yamamoto T, Fazio V W, Tekkis P P. Safety and efficacy of strictureplasty for Crohn’s disease: a systematic review and meta-analysis.  Dis Colon Rectum. 2007;  50 1968-1986
  • 196 Andant C, Godeberge B, Chaussade S. et al . Clinical course of symptomatic duodeno-jejunal Crohn’s disease.  Gastroenterol Clin Biol. 1999;  23 1134-1138
  • 197 Kugathasan S, Werlin S L, Martinez A. et al . Prolonged duration of response to infliximab in early but not late pediatric Crohn’s disease.  Am J Gastroenterol. 2000;  95 3189-3194
  • 198 Lionetti P, Bronzini F, Salvestrini C. et al . Response to infliximab is related to disease duration in paediatric Crohn’s disease.  Aliment Pharmacol Ther. 2003;  18 425-431
  • 199 Tremaine W J. Gastroduodenal Crohn’s disease: medical management.  Inflamm Bowel Dis. 2003;  9 127-128; discussion 131
  • 200 Mottet C, Juillerat P, Gonvers J J. et al . Treatment of gastroduodenal Crohn’s disease.  Digestion. 2005;  71 37-40
  • 201 Miehsler W, Puspok A, Oberhuber T. et al . Impact of different therapeutic regimens on the outcome of patients with Crohn’s disease of the upper gastrointestinal tract.  Inflamm Bowel Dis. 2001;  7 99-105
  • 202 Sandborn W, Sutherland L, Pearson D. et al . Azathioprine or 6-mercaptopurine for inducing remission of Crohn’s disease.  Cochrane Database Syst Rev. 2000;  CD000545
  • 203 Pearson D C, May G R, Fick G. et al . Azathioprine for maintaining remission of Crohn’s disease.  Cochrane Database Syst Rev. 2000;  CD000067
  • 204 Bastida PAz G, Nos Mateu P, Aguas Peris M. et al . Optimization of immunomodulatory treatment with azathioprine or 6-mercaptopurine in inflammatory bowel disease.  Gastroenterol Hepatol. 2007;  30 511-516
  • 205 Alfadhli A A, McDonald J W, Feagan B G. Methotrexate for induction of remission in refractory Crohn’s disease.  Cochrane Database Syst Rev. 2005;  CD003459
  • 206 Fraser A G. Methotrexate: first-line or second-line immunomodulator?.  Eur J Gastroenterol Hepatol. 2003;  15 225-231
  • 207 Mack D R, Young R, Kaufman S S. et al . Methotrexate in patients with Crohn’s disease after 6-mercaptopurine.  J Pediatr. 1998;  132 830-835
  • 208 Uhlen S, Belbouab R, Narebski K. et al . Efficacy of methotrexate in pediatric Crohn’s disease: a French multicenter study.  Inflamm Bowel Dis. 2006;  12 1053-1057
  • 209 Ravikumara M, Hinsberger A, Spray C H. Role of methotrexate in the management of Crohn disease.  J Pediatr Gastroenterol Nutr. 2007;  44 427-430
  • 210 Rogers P, Tybulewicz A T, Pieterse L. et al . Use of Methotrexate to Induce and Maintain Remission in Crohn’s Disease: A Regional Cohort Study.  J Pediatr Gastroenterol Nutr. 2006;  43 S26
  • 211 Targan S R, Hanauer S B, Deventer S J. et al . A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn’s disease. Crohn’s Disease cA2 Study Group.  N Engl J Med. 1997;  337 1029-1035
  • 212 Hanauer S B, Sandborn W J, Rutgeerts van P. et al . Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn’s disease: the CLASSIC-I trial.  Gastroenterology. 2006;  130 323-333; quiz 591
  • 213 Dullemen H M, Deventer van S J, Hommes D W. et al . Treatment of Crohn’s disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2).  Gastroenterology. 1995;  109 129-135
  • 214 Sandborn W J, Feagan B G, Stoinov van S. et al . Certolizumab pegol for the treatment of Crohn’s disease.  N Engl J Med. 2007;  357 228-238
  • 215 Schreiber S, Rutgeerts P, Fedorak R N. et al . A randomized, placebo-controlled trial of certolizumab pegol (CDP870) for treatment of Crohn’s disease.  Gastroenterology. 2005;  129 807-818
  • 216 Hanauer S B, Feagan B G, Lichtenstein G R. et al . Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial.  Lancet. 2002;  359 1541-1549
  • 217 Colombel J F, Sandborn W J, Rutgeerts P. et al . Adalimumab for maintenance of clinical response and remission in patients with Crohn’s disease: the CHARM trial.  Gastroenterology. 2007;  132 52-65
  • 218 Sandborn W J, Hanauer S B, Rutgeerts P. et al . Adalimumab for maintenance treatment of Crohn’s disease: results of the CLASSIC II trial.  Gut. 2007;  56 1232-1239
  • 219 Schreiber S, Khaliq-Kareemi M, Lawrance I C. et al . Maintenance therapy with certolizumab pegol for Crohn’s disease.  N Engl J Med. 2007;  357 239-250
  • 220 Schreiber S. Crohn’s disease – infliximab, adalimumab and certolizumab-pegol: clinical value of anti-TNF-alpha treatment.  Dtsch Med Wochenschr. 2007;  132 1770-1774
  • 221 Franchimont N, Putzeys V, Collette J. et al . Rapid improvement of bone metabolism after infliximab treatment in Crohn’s disease.  Aliment Pharmacol Ther. 2004;  20 607-614
  • 222 Bernstein M, Irwin S, Greenberg G R. Maintenance infliximab treatment is associated with improved bone mineral density in Crohn’s disease.  Am J Gastroenterol. 2005;  100 2031-2035
  • 223 Mauro M, Radovic V, Armstrong D. Improvement of lumbar bone mass after infliximab therapy in Crohn’s disease patients.  Can J Gastroenterol. 2007;  21 637-642
  • 224 Rutgeerts P, Diamond R H, Bala M. et al . Scheduled maintenance treatment with infliximab is superior to episodic treatment for the healing of mucosal ulceration associated with Crohn’s disease.  Gastrointest Endosc. 2006;  63 433-442; quiz 464
  • 225 Froslie K F, Jahnsen J, Moum B A. et al . Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort.  Gastroenterology. 2007;  133 412-422
  • 226 Present D H, Korelitz B I, Wisch N. et al . Treatment of Crohn’s disease with 6-mercaptopurine. A long-term, randomized, double-blind study.  N Engl J Med. 1980;  302 981-987
  • 227 Feagan B G, Rochon J, Fedorak R N. et al . Methotrexate for the treatment of Crohn’s disease. The North American Crohn’s Study Group Investigators.  N Engl J Med. 1995;  332 292-297
  • 228 Cosnes J, Cattan S, Blain A. et al . Long-term evolution of disease behavior of Crohn’s disease.  Inflamm Bowel Dis. 2002;  8 244-250
  • 229 Rutgeerts P. Strategies in the prevention of post-operative recurrence in Crohn’s disease.  Best Pract Res Clin Gastroenterol. 2003;  17 63-73
  • 230 D’Haens G R, Geboes K, Peeters M. et al . Early lesions of recurrent Crohn’s disease caused by infusion of intestinal contents in excluded ileum.  Gastroenterology. 1998;  114 262-267
  • 231 Rutgeerts P, Hiele M, Geboes K. et al . Controlled trial of metronidazole treatment for prevention of Crohn’s recurrence after ileal resection.  Gastroenterology. 1995;  108 1617-1621
  • 232 Lemann M, Mary J Y, Duclos B. et al . Infliximab plus azathioprine for steroid-dependent Crohn’s disease patients: a randomized placebo-controlled trial.  Gastroenterology. 2006;  130 1054-1061
  • 233 Navarro F A, Hanauer S B, Kirschner B S. Effect of long-term low-dose prednisone on height velocity and disease activity in pediatric and adolescent patients with Crohn disease.  J Pediatr Gastroenterol Nutr. 2007;  45 312-318
  • 234 Hyams J, Crandall W, Kugathasan S. et al . Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn’s disease in children.  Gastroenterology. 2007;  132 863-873; quiz 1165 – 1166
  • 235 Newby E A, Sawczenko A, Thomas A G. et al . Interventions for growth failure in childhood Crohn’s disease.  Cochrane Database Syst Rev. 2005;  CD003873
  • 236 Heuschkel R B, Menache C C, Megerian J T. et al . Enteral nutrition and corticosteroids in the treatment of acute Crohn’s disease in children.  J Pediatr Gastroenterol Nutr. 2000;  31 8-15
  • 237 Afzal N A, Davies S, Paintin M. et al . Colonic Crohn’s disease in children does not respond well to treatment with enteral nutrition if the ileum is not involved.  Dig Dis Sci. 2005;  50 1471-1475
  • 238 Levine A, Weizman Z, Broide E. et al . A comparison of budesonide and prednisone for the treatment of active pediatric Crohn disease.  J Pediatr Gastroenterol Nutr. 2003;  36 248-252
  • 239 Brignola C, Campieri M, Bazzocchi G. et al . A laboratory index for predicting relapse in asymptomatic patients with Crohn’s disease.  Gastroenterology. 1986;  91 1490-1494
  • 240 Schreiber S, Nikolaus S, Hampe J. et al . Tumour necrosis factor alpha and interleukin 1beta in relapse of Crohn’s disease.  Lancet. 1999;  353 459-461
  • 241 Papadakis K A, Yang H, Ippoliti A. et al . Anti-flagellin (CBir1) phenotypic and genetic Crohn’s disease associations.  Inflamm Bowel Dis. 2007;  13 524-530
  • 242 Devlin S M, Yang H, Ippoliti A. et al . NOD2 variants and antibody response to microbial antigens in Crohn’s disease patients and their unaffected relatives.  Gastroenterology. 2007;  132 576-586
  • 243 Mei L, Targan S R, Landers C J. et al . Familial expression of anti-Escherichia coli outer membrane porin C in relatives of patients with Crohn’s disease.  Gastroenterology. 2006;  130 1078-1085
  • 244 Targan S R, Landers C J, Yang H. et al . Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn’s disease.  Gastroenterology. 2005;  128 2020-2028
  • 245 Munkholm P, Langholz E, Davidsen M. et al . Disease activity courses in a regional cohort of Crohn’s disease patients.  Scand J Gastroenterol. 1995;  30 699-706
  • 246 Sahmoud T, Hoctin-Boes G, Modigliani R. et al . Identifying patients with a high risk of relapse in quiescent Crohn’s disease. The GETAID Group. The Groupe d’Etudes Therapeutiques des Affections Inflammatoires Digestives.  Gut. 1995;  37 811-818
  • 247 Kamm M A. Review article: chronic active disease and maintaining remission in Crohn’s disease.  Aliment Pharmacol Ther. 2004;  20 (Suppl 4) 102-105
  • 248 Feagan B G. Maintenance therapy for inflammatory bowel disease.  Am J Gastroenterol. 2003;  98 S6-S17
  • 249 Akobeng A K, Gardener E. Oral 5-aminosalicylic acid for maintenance of medically-induced remission in Crohn’s Disease.  Cochrane Database Syst Rev. 2005;  CD003715
  • 250 Mahid S S, Minor K S, Stromberg A J. et al . Active and passive smoking in childhood is related to the development of inflammatory bowel disease.  Inflamm Bowel Dis. 2007;  13 431-438
  • 251 Mahid S S, Minor K S, Soto R E. et al . Smoking and inflammatory bowel disease: a meta-analysis.  Mayo Clin Proc. 2006;  81 1462-1471
  • 252 Timmer A, Sutherland L R, Martin F. Oral contraceptive use and smoking are risk factors for relapse in Crohn’s disease. The Canadian Mesalamine for Remission of Crohn’s Disease Study Group.  Gastroenterology. 1998;  114 1143-1150
  • 253 Kane S V, Flicker M, Katz-Nelson F. Tobacco use is associated with accelerated clinical recurrence of Crohn’s disease after surgically induced remission.  J Clin Gastroenterol. 2005;  39 32-35
  • 254 Simms L, Steinhart A H. Budesonide for maintenance of remission in Crohn’s disease.  Cochrane Database Syst Rev. 2001;  CD002913
  • 255 Steinhart A H, Ewe K, Griffiths A M. et al . Corticosteroids for maintenance of remission in Crohn’s disease.  Cochrane Database Syst Rev. 2003;  CD000301
  • 256 Ludwig D, Stange E F. Efficacy of azathioprine in the treatment of chronic active Crohn’s disease: prospective one-year follow-up study. German Imurek Study Group.  Z Gastroenterol. 1999;  37 1085-1091
  • 257 Bokemeyer B, Teml A, Roggel C. et al . Adherence to thiopurine treatment in out-patients with Crohn’s disease.  Aliment Pharmacol Ther. 2007;  26 217-225
  • 258 Reinshagen M, Schutz E, Armstrong V W. et al . 6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial.  Clin Chem. 2007;  53 1306-1314
  • 259 Lemann M, Mary J Y, Colombel J F. et al . A randomized, double-blind, controlled withdrawal trial in Crohn’s disease patients in long-term remission on azathioprine.  Gastroenterology. 2005;  128 1812-1818
  • 260 Vilien M, Dahlerup J F, Munck L K. et al . Randomized controlled azathioprine withdrawal after more than two years treatment in Crohn’s disease: increased relapse rate the following year.  Aliment Pharmacol Ther. 2004;  19 1147-1152
  • 261 Rutgeerts P, Feagan B G, Lichtenstein G R. et al . Comparison of scheduled and episodic treatment strategies of infliximab in Crohn’s disease.  Gastroenterology. 2004;  126 402-413
  • 262 Hanauer S B, Wagner C L, Bala M. et al . Incidence and importance of antibody responses to infliximab after maintenance or episodic treatment in Crohn’s disease.  Clin Gastroenterol Hepatol. 2004;  2 542-553
  • 263 Vermeire S, Noman M, Van Assche G. et al . Effectiveness of concomitant immunosuppressive therapy in suppressing the formation of antibodies to infliximab in Crohn’s disease.  Gut. 2007;  56 1226-1231
  • 264 Schroder O, Blumenstein I, Stein J. Combining infliximab with methotrexate for the induction and maintenance of remission in refractory Crohn’s disease: a controlled pilot study.  Eur J Gastroenterol Hepatol. 2006;  18 11-16
  • 265 Rutgeerts P, D’Haens G, Targan S. et al . Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn’s disease.  Gastroenterology. 1999;  117 761-769
  • 266 Sandborn W J, Rutgeerts P, Enns R. et al . Adalimumab induction therapy for Crohn disease previously treated with infliximab: a randomized trial.  Ann Intern Med. 2007;  146 829-838
  • 267 Rutgeerts P, Geboes K, Vantrappen G. et al . Predictability of the postoperative course of Crohn’s disease.  Gastroenterology. 1990;  99 956-963
  • 268 Froehlich F, Juillerat P, Pittet V. et al . Maintenance of surgically induced remission of Crohn’s disease.  Digestion. 2007;  76 130-135
  • 269 Hanauer S B, Korelitz B I, Rutgeerts P. et al . Postoperative maintenance of Crohn’s disease remission with 6-mercaptopurine, mesalamine, or placebo: a 2-year trial.  Gastroenterology. 2004;  127 723-729
  • 270 Ardizzone S, Maconi G, Sampietro G M. et al . Azathioprine and mesalamine for prevention of relapse after conservative surgery for Crohn’s disease.  Gastroenterology. 2004;  127 730-740
  • 271 Sutherland L R, Steinhart A H. Mesalazine as a maintenance treatment in Crohn’s disease.  Gut. 1998;  42 143-144
  • 272 Akobeng A K. Review article: the evidence base for interventions used to maintain remission in Crohn’s disease.  Aliment Pharmacol Ther. 2008;  27 11-18
  • 273 Sandborn W J, Feagan B G, Lichtenstein G R. Medical management of mild to moderate Crohn’s disease: evidence-based treatment algorithms for induction and maintenance of remission.  Aliment Pharmacol Ther. 2007;  26 987-1003
  • 274 Rahimi R, Nikfar S, Rezaie A. et al . A meta-analysis of broad-spectrum antibiotic therapy in patients with active Crohn’s disease.  Clin Ther. 2006;  28 1983-1988
  • 275 Prantera C, Berto E, Scribano M L. et al . Use of antibiotics in the treatment of active Crohn’s disease: experience with metronidazole and ciprofloxacin.  Ital J Gastroenterol Hepatol. 1998;  30 602-606
  • 276 Takagi S, Utsunomiya K, Kuriyama S. et al . Effectiveness of an ‘half elemental diet’ as maintenance therapy for Crohn’s disease: A randomized-controlled trial.  Aliment Pharmacol Ther. 2006;  24 1333-1340
  • 277 Wilschanski M, Sherman P, Pencharz P. et al . Supplementary enteral nutrition maintains remission in paediatric Crohn’s disease.  Gut. 1996;  38 543-548
  • 278 Dachverband Osteologie .Prophylaxe, Diagnostik und Therapie der Glukokortikoid-induzierten Osteoporose. Zugriff: 7.5.2008 Online im WWW. URL: http://www.lutherhaus.de/osteo/leitlinien-dvo/PDFs/DVO-Leitlinie% 20Glukokortikoid-Osteoporose% 20Version% 2006 – 09 – 07 % 20.pdf
  • 279 Narendranathan M, Sandler R S, Suchindran C M. et al . Male infertility in inflammatory bowel disease.  J Clin Gastroenterol. 1989;  11 403-406
  • 280 O’Morain C, Smethurst P, Dore C J. et al . Reversible male infertility due to sulphasalazine: studies in man and rat.  Gut. 1984;  25 1078-1084
  • 281 Birnie G G, McLeod T I, Watkinson G. Incidence of sulphasalazine-induced male infertility.  Gut. 1981;  22 452-455
  • 282 Levi A J, Fisher A M, Hughes L. et al . Male infertility due to sulphasalazine.  Lancet. 1979;  2 276-278
  • 283 Toth A. Reversible toxic effect of salicylazosulfapyridine on semen quality.  Fertil Steril. 1979;  31 538-540
  • 284 Gonvers J J, Juillerat P, Mottet C. et al . Maintenance of remission in Crohn’s disease.  Digestion. 2005;  71 41-48
  • 285 Schedel J, Godde A, Schutz E. et al . Impact of thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations in patients with chronic inflammatory diseases.  Ann N Y Acad Sci. 2006;  1069 477-491
  • 286 Colombel J F, Ferrari N, Debuysere H. et al . Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn’s disease and severe myelosuppression during azathioprine therapy.  Gastroenterology. 2000;  118 1025-1030
  • 287 Braun J, Kastner P, Flaxenberg P. et al . Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis: results of a six-month, multicenter, randomized, double-blind, controlled, phase IV trial.  Arthritis Rheum. 2008;  58 73-81
  • 288 Feagan B G, Fedorak R N, Irvine E J. et al . A comparison of methotrexate with placebo for the maintenance of remission in Crohn’s disease. North American Crohn’s Study Group Investigators.  N Engl J Med. 2000;  342 1627-1632
  • 289 Ortiz Z, Shea B, Suarez Almazor M. et al . Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.  Cochrane Database Syst Rev. 2000;  CD000951
  • 290 Arnott I D, Watts D, Satsangi J. Azathioprine and anti-TNF alpha therapies in Crohn’s disease: a review of pharmacology, clinical efficacy and safety.  Pharmacol Res. 2003;  47 1-10
  • 291 Colombel J F, Loftus E V, Tremaine W J. et al . The safety profile of infliximab in patients with Crohn’s disease: the Mayo clinic experience in 500 patients.  Gastroenterology. 2004;  126 19-31
  • 292 Mow W S, Abreu-Martin M T, Papadakis K A. et al . High incidence of anergy in inflammatory bowel disease patients limits the usefulness of PPD screening before infliximab therapy.  Clin Gastroenterol Hepatol. 2004;  2 309-313
  • 293 Sellam Jr J, Hamdi H, Roy C. et al . Comparison of in vitro-specific blood tests with tuberculin skin test for diagnosis of latent tuberculosis before anti-TNF therapy.  Ann Rheum Dis. 2007;  66 1610-1615
  • 294 Listing J, Strangfeld A, Kary S. et al . Infections in patients with rheumatoid arthritis treated with biologic agents.  Arthritis Rheum. 2005;  52 3403-3412
  • 295 Dixon W G, Watson K, Lunt M. et al . Rates of serious infection, including site-specific and bacterial intracellular infection, in rheumatoid arthritis patients receiving anti-tumor necrosis factor therapy: results from the British Society for Rheumatology Biologics Register.  Arthritis Rheum. 2006;  54 2368-2376
  • 296 Curtis J R, Patkar N, Xie A. et al . Risk of serious bacterial infections among rheumatoid arthritis patients exposed to tumor necrosis factor alpha antagonists.  Arthritis Rheum. 2007;  56 1125-1133
  • 297 Rosh J R, Gross T, Mamula P. et al . Hepatosplenic T-cell lymphoma in adolescents and young adults with Crohn’s disease: a cautionary tale?.  Inflamm Bowel Dis. 2007;  13 1024-1030
  • 298 Comby E, Tanaff P, Mariotte D. et al . Evolution of antinuclear antibodies and clinical patterns in patients with active rheumatoid arthritis with longterm infliximab therapy.  J Rheumatol. 2006;  33 24-30
  • 299 Costa M F, Said N R, Zimmermann B. Drug-induced lupus due to anti-tumor necrosis factor alpha agents.  Semin Arthritis Rheum. 2008;  37 381-387
  • 300 Baird D D, Narendranathan M, Sandler R S. Increased risk of preterm birth for women with inflammatory bowel disease.  Gastroenterology. 1990;  99 987-994
  • 301 Khosla R, Willoughby C P, Jewell D P. Crohn’s disease and pregnancy.  Gut. 1984;  25 52-56
  • 302 Woolfson K, Cohen Z, McLeod R S. Crohn’s disease and pregnancy.  Dis Colon Rectum. 1990;  33 869-873
  • 303 Fonager K, Sorensen H T, Olsen J. et al . Pregnancy outcome for women with Crohn’s disease: a follow-up study based on linkage between national registries.  Am J Gastroenterol. 1998;  93 2426-2430
  • 304 Baiocco P J, Korelitz B I. The influence of inflammatory bowel disease and its treatment on pregnancy and fetal outcome.  J Clin Gastroenterol. 1984;  6 211-216
  • 305 Mayberry J F, Weterman I T. European survey of fertility and pregnancy in women with Crohn’s disease: a case control study by European collaborative group.  Gut. 1986;  27 821-825
  • 306 Hudson M, Flett G, Sinclair T S. et al . Fertility and pregnancy in inflammatory bowel disease.  Int J Gynaecol Obstet. 1997;  58 229-237
  • 307 Ravid A, Richard C S, Spencer L M. et al . Pregnancy, delivery, and pouch function after ileal pouch-anal anastomosis for ulcerative colitis.  Dis Colon Rectum. 2002;  45 1283-1288
  • 308 Ording Olsen K, Juul S, Berndtsson I. et al . Ulcerative colitis: female fecundity before diagnosis, during disease, and after surgery compared with a population sample.  Gastroenterology. 2002;  122 15-19
  • 309 Juhasz E S, Fozard B, Dozois R R. et al . Ileal pouch-anal anastomosis function following childbirth. An extended evaluation.  Dis Colon Rectum. 1995;  38 159-165
  • 310 Hanan I M, Kirsner J B. Inflammatory bowel disease in the pregnant woman.  Clin Perinatol. 1985;  12 669-682
  • 311 Larzilliere I, Beau P. Chronic inflammatory bowel disease and pregnancy. Case control study.  Gastroenterol Clin Biol. 1998;  22 1056-1060
  • 312 Miller J P. Inflammatory bowel disease in pregnancy: a review.  J R Soc Med. 1986;  79 221-225
  • 313 Korelitz B I. Inflammatory bowel disease and pregnancy.  Gastroenterol Clin North Am. 1998;  27 213-224
  • 314 Fedorkow D M, Persaud D, Nimrod C A. Inflammatory bowel disease: a controlled study of late pregnancy outcome.  Am J Obstet Gynecol. 1989;  160 998-1001
  • 315 Mogadam M, Korelitz B I, Ahmed S W. et al . The course of inflammatory bowel disease during pregnancy and postpartum.  Am J Gastroenterol. 1981;  75 265-269
  • 316 Alstead E M. Inflammatory bowel disease in pregnancy.  Postgrad Med J. 2002;  78 23-26
  • 317 Castile R G, Telander R L, Cooney D R. et al . Crohn’s disease in children: assessment of the progression of disease, growth, and prognosis.  J Pediatr Surg. 1980;  15 462-469
  • 318 Nwokolo C U, Tan W C, Andrews H A. et al . Surgical resections in parous patients with distal ileal and colonic Crohn’s disease.  Gut. 1994;  35 220-223
  • 319 Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy.  Gastroenterology. 2006;  131 283-311
  • 320 Ilnyckyji A, Blanchard J F, Rawsthorne P. et al . Perianal Crohn’s disease and pregnancy: role of the mode of delivery.  Am J Gastroenterol. 1999;  94 3274-3278
  • 321 Nelson H, Dozois R R, Kelly K A. et al . The effect of pregnancy and delivery on the ileal pouch-anal anastomosis functions.  Dis Colon Rectum. 1989;  32 384-388
  • 322 Nicholl M C, Thompson J M, Cocks P S. Stomas and pregnancy.  Aust N Z J Obstet Gynaecol. 1993;  33 322-324
  • 323 Ramalingam T, Box B, Mortensen N M. Pregnancy delivery and pouch function after ileal pouch-anal anastomosis for ulcerative colitis.  Dis Colon Rectum. 2003;  46 1292
  • 324 Brandt L J, Estabrook S G, Reinus J F. Results of a survey to evaluate whether vaginal delivery and episiotomy lead to perineal involvement in women with Crohn’s disease.  Am J Gastroenterol. 1995;  90 1918-1922
  • 325 Edwards J T, Radford-Smith G L, Florin T H. Chronic narcotic use in inflammatory bowel disease patients: prevalence and clinical characteristics.  J Gastroenterol Hepatol. 2001;  16 1235-1238
  • 326 Cross R K, Wilson K T, Binion D G. Narcotic use in patients with Crohn’s disease.  Am J Gastroenterol. 2005;  100 2225-2229
  • 327 Janke K H, Klump B, Gregor M. et al . Determinants of life satisfaction in inflammatory bowel disease.  Inflamm Bowel Dis. 2005;  11 272-286
  • 328 Cross R K, Wilson K T, Binion D G. Polypharmacy and Crohn’s disease.  Aliment Pharmacol Ther. 2005;  21 1211-1216
  • 329 Kopf A, Janson W, Stein C. Anwendungsmöglichkeiten fur Opioide bei chronischem Nichttumorschmerz.  Anaesthesist. 2003;  52 103-114
  • 330 Gerson L B, Triadafilopoulos G. Palliative care in inflammatory bowel disease: an evidence-based approach.  Inflamm Bowel Dis. 2000;  6 228-243
  • 331 Forrest K, Symmons D, Foster P. Systematic review: is ingestion of paracetamol or non-steroidal anti-inflammatory drugs associated with exacerbations of inflammatory bowel disease?.  Aliment Pharmacol Ther. 2004;  20 1035-1043
  • 332 Arundel C, Lewis J H. Drug-induced liver disease in 2006.  Curr Opin Gastroenterol. 2007;  23 244-254
  • 333 Kaplan M A, Korelitz B I. Narcotic dependence in inflammatory bowel disease.  J Clin Gastroenterol. 1988;  10 275-278
  • 334 Wambach S, Rohr P, Häuser W. Opioidtherapiemissbrauch bei anhaltender somatoformer Schmerzstörung zur Indikationsdiskussion von Opioiden bei chronischen benignen Schmerzsyndromen aus psychosomatisch-schmerztherapeutischer Sicht.  Schmerz. 2001;  15 254-264
  • 335 Jones J L, Loftus E V. Avoiding the vicious cycle of prolonged opioid use in Crohn’s disease.  Am J Gastroenterol. 2005;  100 2230-2232
  • 336 White Jr M, Shah N, Lindley K. et al . Pain management in fulminating ulcerative colitis.  Paediatr Anaesth. 2006;  16 1148-1152
  • 337 Minderhoud I M, Oldenburg B, Wismeijer J A. et al . IBS-like symptoms in patients with inflammatory bowel disease in remission; relationships with quality of life and coping behavior.  Dig Dis Sci. 2004;  49 469-474
  • 338 Simren M, Axelsson J, Gillberg R. et al . Quality of life in inflammatory bowel disease in remission: the impact of IBS-like symptoms and associated psychological factors.  Am J Gastroenterol. 2002;  97 389-396
  • 339 Spiller R, Aziz Q, Creed F. et al . Guidelines on the irritable bowel syndrome: mechanisms and practical management.  Gut. 2007;  56 1770-1798
  • 340 Heuman R, Boeryd B, Bolin T. et al . The influence of disease at the margin of resection on the outcome of Crohn’s disease.  Br J Surg. 1983;  70 519-521
  • 341 Solberg I C, Vatn M H, Hoie O. et al . Clinical course in Crohn’s disease: results of a Norwegian population-based ten-year follow-up study.  Clin Gastroenterol Hepatol. 2007;  5 1430-1438
  • 342 Graadal O, Nygaard K. Crohn disease. Long-term effects of surgical treatment.  Tidsskr Nor Laegeforen. 1994;  114 1603-1605
  • 343 Nordgren S R, Fasth S B, Oresland T O. et al . Long-term follow-up in Crohn’s disease. Mortality, morbidity, and functional status.  Scand J Gastroenterol. 1994;  29 1122-1128
  • 344 Weston L A, Roberts P L, Schoetz D J. et al . Ileocolic resection for acute presentation of Crohn’s disease of the ileum.  Dis Colon Rectum. 1996;  39 841-846
  • 345 Kim N K, Senagore A J, Luchtefeld M A. et al . Long-term outcome after ileocecal resection for Crohn’s disease.  Am Surg. 1997;  63 627-633
  • 346 Tillinger Jr W, Mittermaier C, Lochs H. et al . Health-related quality of life in patients with Crohn’s disease: influence of surgical operation – a prospective trial.  Dig Dis Sci. 1999;  44 932-938
  • 347 Golfieri R, Cappelli A, Giampalma E. et al . CT-guided percutaneous pelvic abscess drainage in Crohn’s disease.  Tech Coloproctol. 2006;  10 99-105
  • 348 Yamaguchi A, Matsui T, Sakurai T. et al . The clinical characteristics and outcome of intraabdominal abscess in Crohn’s disease.  J Gastroenterol. 2004;  39 441-448
  • 349 Gervais D A, Hahn P F, O’Neill M J. et al . Percutaneous abscess drainage in Crohn disease: technical success and short- and long-term outcomes during 14 years.  Radiology. 2002;  222 645-651
  • 350 Garcia J C, Persky S E, Bonis P A. et al . Abscesses in Crohn’s disease: outcome of medical versus surgical treatment.  J Clin Gastroenterol. 2001;  32 409-412
  • 351 Michelassi F, Upadhyay G A. Side-to-side isoperistaltic strictureplasty in the treatment of extensive Crohn’s disease.  J Surg Res. 2004;  117 71-78
  • 352 Sampietro G M, Sartani A, Danelli P. et al . Strictureplasty in the surgical treatment of complicated Crohn’s disease.  Ann Ital Chir. 2003;  74 659-663
  • 353 Tonelli F, Fedi M, Paroli G M. et al . Indications and results of side-to-side isoperistaltic strictureplasty in Crohn’s disease.  Dis Colon Rectum. 2004;  47 494-501
  • 354 Shatari T, Clark M A, Yamamoto T. et al . Long strictureplasty is as safe and effective as short strictureplasty in small-bowel Crohn’s disease.  Colorectal Dis. 2004;  6 438-441
  • 355 Poggioli G, Laureti S, Pierangeli F. et al . A new model of strictureplasty for multiple and long stenoses in Crohn’s ileitis: side-to-side diseased to disease-free anastomosis.  Dis Colon Rectum. 2003;  46 127-130
  • 356 Tichansky D, Cagir B, Yoo E. et al . Strictureplasty for Crohn’s disease: meta-analysis.  Dis Colon Rectum. 2000;  43 911-919
  • 357 Roy P, Kumar D. Strictureplasty for active Crohn’s disease.  Int J Colorectal Dis. 2006;  21 427-432
  • 358 Fearnhead N S, Chowdhury R, Box B. et al . Long-term follow-up of strictureplasty for Crohn’s disease.  Br J Surg. 2006;  93 475-482
  • 359 Dietz D W, Fazio V W, Laureti S. et al . Strictureplasty in diffuse Crohn’s jejunoileitis: safe and durable.  Dis Colon Rectum. 2002;  45 764-770
  • 360 Broering D C, Eisenberger C F, Koch A. et al . Strictureplasty for large bowel stenosis in Crohn’s disease: quality of life after surgical therapy.  Int J Colorectal Dis. 2001;  16 81-87
  • 361 Broering D C, Eisenberger C F, Koch A. et al . Quality of life after surgical therapy of small bowel stenosis in Crohn’s disease.  Dig Surg. 2001;  18 124-130
  • 362 Dietz D W, Laureti S, Strong S A. et al . Safety and longterm efficacy of strictureplasty in 314 patients with obstructing small bowel Crohn’s disease.  J Am Coll Surg. 2001;  192 330-337; discussion 337 – 338
  • 363 Yamamoto T, Allan R N, Keighley M R. Long-term outcome of surgical management for diffuse jejunoileal Crohn’s disease.  Surgery. 2001;  129 96-102
  • 364 Sampietro G M, Cristaldi M, Maconi G. et al . A prospective, longitudinal study of nonconventional strictureplasty in Crohn’s disease.  J Am Coll Surg. 2004;  199 8-20; discussion 20 – 22
  • 365 Benoist S, Panis Y, Beaufour A. et al . Laparoscopic ileocecal resection in Crohn’s disease: a case-matched comparison with open resection.  Surg Endosc. 2003;  17 814-818
  • 366 Tabet J, Hong D, Kim C W. et al . Laparoscopic versus open bowel resection for Crohn’s disease.  Can J Gastroenterol. 2001;  15 237-242
  • 367 Marcello P W, Milsom J W, Wong S K. et al . Laparoscopic restorative proctocolectomy: case-matched comparative study with open restorative proctocolectomy.  Dis Colon Rectum. 2000;  43 604-608
  • 368 Milsom J W, Hammerhofer K A, Bohm B. et al . Prospective, randomized trial comparing laparoscopic vs. conventional surgery for refractory ileocolic Crohn’s disease.  Dis Colon Rectum. 2001;  44 1-8; discussion 8 – 9
  • 369 Maartense S, Dunker M S, Slors J F. et al . Laparoscopic-assisted versus open ileocolic resection for Crohn’s disease: a randomized trial.  Ann Surg. 2006;  243 143-149; discussion 150 – 143
  • 370 Tilney H S, Constantinides V A, Heriot A G. et al . Comparison of laparoscopic and open ileocecal resection for Crohn’s disease: a metaanalysis.  Surg Endosc. 2006;  20 1036-1044
  • 371 Rosman A S, Melis M, Fichera A. Metaanalysis of trials comparing laparoscopic and open surgery for Crohn’s disease.  Surg Endosc. 2005;  19 1549-1555
  • 372 Bernell O, Lapidus A, Hellers G. Recurrence after colectomy in Crohn’s colitis.  Dis Colon Rectum. 2001;  44 647-654; discussion 654
  • 373 Allan A, Andrews H, Hilton C J. et al . Segmental colonic resection is an appropriate operation for short skip lesions due to Crohn’s disease in the colon.  World J Surg. 1989;  13 611-614; discussion 615 – 616
  • 374 Yamamoto T, Keighley M R. Proctocolectomy is associated with a higher complication rate but carries a lower recurrence rate than total colectomy and ileorectal anastomosis in Crohn colitis.  Scand J Gastroenterol. 1999;  34 1212-1215
  • 375 Tonelli F, Paroli G M. Colorectal Crohn’s disease: indications to surgical treatment.  Ann Ital Chir. 2003;  74 665-672
  • 376 Longo W E, Ballantyne G H, Cahow C E. Treatment of Crohn’s colitis. Segmental or total colectomy?.  Arch Surg. 1988;  123 588-590
  • 377 Andersson P, Olaison G, Hallbook O. et al . Segmental resection or subtotal colectomy in Crohn’s colitis?.  Dis Colon Rectum. 2002;  45 47-53
  • 378 Tekkis P P, Purkayastha S, Lanitis S. et al . A comparison of segmental v. subtotal/total colectomy for colonic Crohn’s disease: a meta-analysis.  Colorectal Dis. 2006;  8 82-90
  • 379 Fichera A, McCormack R, Rubin M A. et al . Long-term outcome of surgically treated Crohn’s colitis: a prospective study.  Dis Colon Rectum. 2005;  48 963-969
  • 380 Kersting S, Bruewer M, Laukoetter M G. et al . Intestinal cancer in patients with Crohn’s disease.  Int J Colorectal Dis. 2007;  22 411-417
  • 381 Oca de J, Sanchez-Santos R, Rague J M. et al . Long-term results of ileal pouch-anal anastomosis in Crohn’s disease.  Inflamm Bowel Dis. 2003;  9 171-175
  • 382 Sagar P M, Dozois R R, Wolff B G. Long-term results of ileal pouch-anal anastomosis in patients with Crohn’s disease.  Dis Colon Rectum. 1996;  39 893-898
  • 383 Handelsman J C, Gottlieb L M, Hamilton S R. Crohn’s disease as a contraindication to Kock pouch (continent ileostomy).  Dis Colon Rectum. 1993;  36 840-843
  • 384 Hyman N H, Fazio V W, Tuckson W B. et al . Consequences of ileal pouch-anal anastomosis for Crohn’s colitis.  Dis Colon Rectum. 1991;  34 653-657
  • 385 Panis Y, Poupard B, Nemeth J. et al . Ileal pouch/anal anastomosis for Crohn’s disease.  Lancet. 1996;  347 854-857
  • 386 Regimbeau J M, Panis Y, Pocard M. et al . Long-term results of ileal pouch-anal anastomosis for colorectal Crohn’s disease.  Dis Colon Rectum. 2001;  44 769-778
  • 387 Reese G E, Lovegrove R E, Tilney H S. et al . The effect of Crohn’s disease on outcomes after restorative proctocolectomy.  Dis Colon Rectum. 2007;  50 239-250
  • 388 Marchal L, D’Haens G, Van Assche G. et al . The risk of post-operative complications associated with infliximab therapy for Crohn’s disease: a controlled cohort study.  Aliment Pharmacol Ther. 2004;  19 749-754
  • 389 Colombel J F, Loftus E V, Tremaine W J. et al . Early postoperative complications are not increased in patients with Crohn’s disease treated perioperatively with infliximab or immunosuppressive therapy.  Am J Gastroenterol. 2004;  99 878-883
  • 390 Yamamoto Jr T, Allan R N, Keighley M R. Risk factors for intra-abdominal sepsis after surgery in Crohn’s disease.  Dis Colon Rectum. 2000;  43 1141-1145
  • 391 Aberra F N, Lewis J D, Hass D. et al . Corticosteroids and immunomodulators: postoperative infectious complication risk in inflammatory bowel disease patients.  Gastroenterology. 2003;  125 320-327
  • 392 Mahadevan U, Loftus E V, Tremaine W J. et al . Azathioprine or 6-mercaptopurine before colectomy for ulcerative colitis is not associated with increased postoperative complications.  Inflamm Bowel Dis. 2002;  8 311-316
  • 393 Heuschen U A, Hinz Jr U, Allemeyer E H. et al . Risk factors for ileoanal J pouch-related septic complications in ulcerative colitis and familial adenomatous polyposis.  Ann Surg. 2002;  235 207-216
  • 394 Bruewer M, Utech M, Rijcken E J. et al . Preoperative steroid administration: effect on morbidity among patients undergoing intestinal bowel resection for Crohns disease.  World J Surg. 2003;  27 1306-1310
  • 395 Page M J, Poritz L S, Kunselman S J. et al . Factors affecting surgical risk in elderly patients with inflammatory bowel disease.  J Gastrointest Surg. 2002;  6 606-613
  • 396 Tay G S, Binion D G, Eastwood D. et al . Multivariate analysis suggests improved perioperative outcome in Crohn’s disease patients receiving immunomodulator therapy after segmental resection and/or strictureplasty.  Surgery. 2003;  134 565-572; discussion 572 – 563
  • 397 Myrelid P, Andersson P, Sjödahl R. et al . Immunosuppression for Crohn’s disease is associated with increased frequency of anastomotic complications.  Colorectal Dis. 2004;  6 26
  • 398 Weimann A, Braga M, Harsanyi L. et al . ESPEN Guidelines on Enteral Nutrition: Surgery including organ transplantation.  Clin Nutr. 2006;  25 224-244
  • 399 Weimann A, Ebener C, Hauser L. et al . Leitlinie Parenterale Ernährung: Chirurgie und Transplantation.  Aktuel Ernaehr Med. 2007;  32 S114-S123
  • 400 Hellers G, Bergstrand O, Ewerth S. et al . Occurrence and outcome after primary treatment of anal fistulae in Crohn’s disease.  Gut. 1980;  21 525-527
  • 401 Schwartz D A, Loftus E V, Tremaine W J. et al . The natural history of fistulizing Crohn’s disease in Olmsted County, Minnesota.  Gastroenterology. 2002;  122 875-880
  • 402 Hellers Jr G. Crohn’s disease in Stockholm county 1955 – 1974. A study of epidemiology, results of surgical treatment and long-term prognosis.  Acta Chir Scand Suppl. 1979;  490 1-84
  • 403 Schwartz D A, Wiersema M J, Dudiak K M. et al . A comparison of endoscopic ultrasound, magnetic resonance imaging, and exam under anesthesia for evaluation of Crohn’s perianal fistulas.  Gastroenterology. 2001;  121 1064-1072
  • 404 Bodegraven A A, Sloots C E, Felt-Bersma R J. et al . Endosonographic evidence of persistence of Crohn’s disease-associated fistulas after infliximab treatment, irrespective of clinical response.  Dis Colon Rectum. 2002;  45 39-45; discussion 45 – 36
  • 405 Sloots C E, Felt-Bersma R J, Poen A C. et al . Assessment and classification of fistula-in-ano in patients with Crohn’s disease by hydrogen peroxide enhanced transanal ultrasound.  Int J Colorectal Dis. 2001;  16 292-297
  • 406 Orsoni van P, Barthet M, Portier F. et al . Prospective comparison of endosonography, magnetic resonance imaging and surgical findings in anorectal fistula and abscess complicating Crohn’s disease.  Br J Surg. 1999;  86 360-364
  • 407 Schwartz D A, White C M, Wise P E. et al . Use of endoscopic ultrasound to guide combination medical and surgical therapy for patients with Crohn’s perianal fistulas.  Inflamm Bowel Dis. 2005;  11 727-732
  • 408 Buchanan G N, Bartram C I, Williams A B. et al . Value of hydrogen peroxide enhancement of three-dimensional endoanal ultrasound in fistula-in-ano.  Dis Colon Rectum. 2005;  48 141-147
  • 409 West R L, Woude C J, Hansen B E. et al . Clinical and endosonographic effect of ciprofloxacin on the treatment of perianal fistulae in Crohn’s disease with infliximab: a double-blind placebo-controlled study.  Aliment Pharmacol Ther. 2004;  20 1329-1336
  • 410 Ardizzone van der S, Maconi G, Colombo E. et al . Perianal fistulae following infliximab treatment: clinical and endosonographic outcome.  Inflamm Bowel Dis. 2004;  10 91-96
  • 411 Wedemeyer J, Kirchhoff T, Manns M P. et al . Transcutaneous perianal ultrasound (PAUS) for the imaging of fistulas and abscesses in Crohn’s disease.  Z Gastroenterol. 2004;  42 1315-1320
  • 412 Stewart L K, McGee J, Wilson S R. Transperineal and transvaginal sonography of perianal inflammatory disease.  Am J Roentgenol. 2001;  177 627-632
  • 413 Beets-Tan R G, Beets G L, Hoop A G. et al . Preoperative MR imaging of anal fistulas: Does it really help the surgeon?.  Radiology. 2001;  218 75-84
  • 414 Parks A G, Gordon P H, Hardcastle J D. A classification of fistula-in-ano.  Br J Surg. 1976;  63 1-12
  • 415 Bell S J, Williams A B, Wiesel van der P. et al . The clinical course of fistulating Crohn’s disease.  Aliment Pharmacol Ther. 2003;  17 1145-1151
  • 416 Thornton M, Solomon M J. Long-term indwelling seton for complex anal fistulas in Crohn’s disease.  Dis Colon Rectum. 2005;  48 459-463
  • 417 Rasul I, Wilson S R, MacRae H. et al . Clinical and radiological responses after infliximab treatment for perianal fistulizing Crohn’s disease.  Am J Gastroenterol. 2004;  99 82-88
  • 418 Sandborn W J, Fazio V W, Feagan B G. et al . AGA technical review on perianal Crohn’s disease.  Gastroenterology. 2003;  125 1508-1530
  • 419 O’Donoghue D P, Hyland J M. Perianal Crohn’s disease.  Eur J Gastroenterol Hepatol. 1997;  9 235-236
  • 420 Sangwan Y P, Schoetz D J, Murray J J. et al . Perianal Crohn’s disease. Results of local surgical treatment.  Dis Colon Rectum. 1996;  39 529-535
  • 421 Lichtenstein G R. Treatment of fistulizing Crohn’s disease.  Gastroenterology. 2000;  119 1132-1147
  • 422 Bernstein L H, Frank M S, Brandt L J. et al . Healing of perineal Crohn’s disease with metronidazole.  Gastroenterology. 1980;  79 357-365
  • 423 Buchanan G N, Owen H A, Torkington Jr J. et al . Long-term outcome following loose-seton technique for external sphincter preservation in complex anal fistula.  Br J Surg. 2004;  91 476-480
  • 424 Takesue Y, Ohge H, Yokoyama T. et al . Long-term results of seton drainage on complex anal fistulae in patients with Crohn’s disease.  J Gastroenterol. 2002;  37 912-915
  • 425 Sonoda T, Hull T, Piedmonte M R. et al . Outcomes of primary repair of anorectal and rectovaginal fistulas using the endorectal advancement flap.  Dis Colon Rectum. 2002;  45 1622-1628
  • 426 Hagen S J, Baeten C G, Soeters P B. et al . Anti-TNF-alpha (infliximab) used as induction treatment in case of active proctitis in a multistep strategy followed by definitive surgery of complex anal fistulas in Crohn’s disease: a preliminary report.  Dis Colon Rectum. 2005;  48 758-767
  • 427 Topstad D R, Panaccione van der R, Heine J A. et al . Combined seton placement, infliximab infusion, and maintenance immunosuppressives improve healing rate in fistulizing anorectal Crohn’s disease: a single center experience.  Dis Colon Rectum. 2003;  46 577-583
  • 428 Regueiro M, Mardini H. Treatment of perianal fistulizing Crohn’s disease with infliximab alone or as an adjunct to exam under anesthesia with seton placement.  Inflamm Bowel Dis. 2003;  9 98-103
  • 429 Hyder S A, Travis S P, Jewell D P. et al . Fistulating anal Crohn’s disease: results of combined surgical and infliximab treatment.  Dis Colon Rectum. 2006;  49 1837-1841
  • 430 Lindsey I, Smilgin-Humphreys M M, Cunningham C. et al . A randomized, controlled trial of fibrin glue vs. conventional treatment for anal fistula.  Dis Colon Rectum. 2002;  45 1608-1615
  • 431 Ozuner G, Hull T L, Cartmill J. et al . Long-term analysis of the use of transanal rectal advancement flaps for complicated anorectal/vaginal fistulas.  Dis Colon Rectum. 1996;  39 10-14
  • 432 Scott N A, Nair A, Hughes L E. Anovaginal and rectovaginal fistula in patients with Crohn’s disease.  Br J Surg. 1992;  79 1379-1380
  • 433 Buhr H J, Kroesen A J, Herfarth C. Surgical therapy of recurrent Crohn disease.  Chirurg. 1995;  66 764-773
  • 434 Dejaco C, Harrer M, Waldhoer T. et al . Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn’s disease.  Aliment Pharmacol Ther. 2003;  18 1113-1120
  • 435 Luna-Chadid M, Perez Calle J L, Mendoza J L. et al . Predictors of response to infliximab in patients with fistulizing Crohn’s disease.  Rev Esp Enferm Dig. 2004;  96 379-381; 382 – 374
  • 436 Poritz L S, Gagliano G A, McLeod R S. et al . Surgical management of entero and colocutaneous fistulae in Crohn’s disease: 17 year’s experience.  Int J Colorectal Dis. 2004;  19 481-485; discussion 486
  • 437 Sands B E, Anderson F H, Bernstein C N. et al . Infliximab maintenance therapy for fistulizing Crohn’s disease.  N Engl J Med. 2004;  350 876-885
  • 438 Poritz L S, Rowe W A, Koltun W A. Remicade does not abolish the need for surgery in fistulizing Crohn’s disease.  Dis Colon Rectum. 2002;  45 771-775
  • 439 Sonnenberg A, Gavin M W. Timing of surgery for enterovesical fistula in Crohn’s disease: decision analysis using a time-dependent compartment model.  Inflamm Bowel Dis. 2000;  6 280-285
  • 440 Brandt L J, Bernstein L H, Boley S J. et al . Metronidazole therapy for perineal Crohn’s disease: a follow-up study.  Gastroenterology. 1982;  83 383-387
  • 441 Jakobovits J, Schuster M M. Metronidazole therapy for Crohn’s disease and associated fistulae.  Am J Gastroenterol. 1984;  79 533-540
  • 442 Pearson D C, May G R, Fick G H. et al . Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis.  Ann Intern Med. 1995;  123 132-142
  • 443 Lecomte T, Contou J F, Beaugerie L. et al . Predictive factors of response of perianal Crohn’s disease to azathioprine or 6-mercaptopurine.  Dis Colon Rectum. 2003;  46 1469-1475
  • 444 Korelitz B I, Adler D J, Mendelsohn R A. et al . Long-term experience with 6-mercaptopurine in the treatment of Crohn’s disease.  Am J Gastroenterol. 1993;  88 1198-1205
  • 445 Present D H, Rutgeerts P, Targan S. et al . Infliximab for the treatment of fistulas in patients with Crohn’s disease.  N Engl J Med. 1999;  340 1398-1405
  • 446 Sands B E, Blank M A, Patel K. et al . Long-term treatment of rectovaginal fistulas in Crohn’s disease: response to infliximab in the ACCENT II Study.  Clin Gastroenterol Hepatol. 2004;  2 912-920
  • 447 Lichtenstein G R, Yan S, Bala M. et al . Infliximab maintenance treatment reduces hospitalizations, surgeries, and procedures in fistulizing Crohn’s disease.  Gastroenterology. 2005;  128 862-869
  • 448 Farrell R J, Shah S A, Lodhavia P J. et al . Clinical experience with infliximab therapy in 100 patients with Crohn’s disease.  Am J Gastroenterol. 2000;  95 3490-3497
  • 449 Ricart E, Panaccione R, Loftus E V. et al . Infliximab for Crohn’s disease in clinical practice at the Mayo Clinic: the first 100 patients.  Am J Gastroenterol. 2001;  96 722-729
  • 450 Sandborn W J. A critical review of cyclosporine therapy in inflammatoy bowel disease.  Inflamm Bowel Dis. 1995;  1 48-63
  • 451 Sandborn W J. Preliminary report on the use of oral tacrolimus (FK506) in the treatment of complicated proximal small bowel and fistulizing Crohn’s disease.  Am J Gastroenterol. 1997;  92 876-879
  • 452 Fellermann K, Ludwig D, Stahl M. et al . Steroid-unresponsive acute attacks of inflammatory bowel disease: immunomodulation by tacrolimus (FK506).  Am J Gastroenterol. 1998;  93 1860-1866
  • 453 Lowry P W, Weaver A L, Tremaine W J. et al . Combination therapy with oral tacrolimus (FK506) and azathioprine or 6-mercaptopurine for treatment-refractory Crohn’s disease perianal fistulae.  Inflamm Bowel Dis. 1999;  5 239-245
  • 454 Ierardi E, Principi M, Francavilla R. et al . Oral tacrolimus long-term therapy in patients with Crohn’s disease and steroid resistance.  Aliment Pharmacol Ther. 2001;  15 371-377
  • 455 Sandborn W J, Present D H, Isaacs K L. et al . Tacrolimus for the treatment of fistulas in patients with Crohn’s disease: a randomized, placebo-controlled trial.  Gastroenterology. 2003;  125 380-388
  • 456 Wenzl H H, Hinterleitner T A, Aichbichler B W. et al . Mycophenolate mofetil for Crohn’s disease: short-term efficacy and long-term outcome.  Aliment Pharmacol Ther. 2004;  19 427-434
  • 457 Ehrenpreis E D, Kane S V, Cohen L B. et al . Thalidomide therapy for patients with refractory Crohn’s disease: an open-label trial.  Gastroenterology. 1999;  117 1271-1277
  • 458 Vasiliauskas E A, Kam L Y, Abreu-Martin M T. et al . An open-label pilot study of low-dose thalidomide in chronically active, steroid-dependent Crohn’s disease.  Gastroenterology. 1999;  117 1278-1287
  • 459 Colombel J F, Mathieu D, Bouault J M. et al . Hyperbaric oxygenation in severe perineal Crohn’s disease.  Dis Colon Rectum. 1995;  38 609-614
  • 460 Vaughan D, Drumm B. Treatment of fistulas with granulocyte colony-stimulating factor in a patient with Crohn’s disease.  N Engl J Med. 1999;  340 239-240
  • 461 Levy C, Tremaine W J. Management of internal fistulas in Crohn’s disease.  Inflamm Bowel Dis. 2002;  8 106-111
  • 462 Greenstein A J, Janowitz H D, Sachar D B. The extra-intestinal complications of Crohn’s disease and ulcerative colitis: a study of 700 patients.  Medicine (Baltimore). 1976;  55 401-412
  • 463 Dougados M, Linden van der S, Juhlin R. et al . The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy.  Arthritis Rheum. 1991;  34 1218-1227
  • 464 Orchard T R, Wordsworth B P, Jewell D P. Peripheral arthropathies in inflammatory bowel disease: their articular distribution and natural history.  Gut. 1998;  42 387-391
  • 465 Vlam de K, Mielants H, Cuvelier C. et al . Spondyloarthropathy is underestimated in inflammatory bowel disease: prevalence and HLA association.  J Rheumatol. 2000;  27 2860-2865
  • 466 Gran J T, Husby G. Joint manifestations in gastrointestinal diseases. 1. Pathophysiological aspects, ulcerative colitis and Crohn’s disease.  Dig Dis. 1992;  10 274-294
  • 467 Protzer U, Duchmann R, Hohler T. et al . Enteropathic spondylarthritis in chronic inflammatory bowel diseases: prevalence, manifestation pattern and HLA association.  Med Klin. 1996;  91 330-335
  • 468 Braun J, Bollow M, Remlinger G. et al . Prevalence of spondylarthropathies in HLA-B27 positive and negative blood donors.  Arthritis Rheum. 1998;  41 58-67
  • 469 El Miedany Y, Youssef S, Ahmed I. et al . The gastrointestinal safety and effect on disease activity of etoricoxib, a selective cox-2 inhibitor in inflammatory bowel diseases.  Am J Gastroenterol. 2006;  101 311-317
  • 470 Sandborn W J, Stenson W F, Brynskov J. et al . Safety of celecoxib in patients with ulcerative colitis in remission: a randomized, placebo-controlled, pilot study.  Clin Gastroenterol Hepatol. 2006;  4 203-211
  • 471 Braun J, Brandt J, Listing J. et al . Treatment of active ankylosing spondylitis with infliximab: a randomised controlled multicentre trial.  Lancet. 2002;  359 1187-1193
  • 472 Generini S, Giacomelli R, Fedi R. et al . Infliximab in spondyloarthropathy associated with Crohn’s disease: an open study on the efficacy of inducing and maintaining remission of musculoskeletal and gut manifestations.  Ann Rheum Dis. 2004;  63 1664-1669
  • 473 Herfarth H, Obermeier F, Andus T. et al . Improvement of arthritis and arthralgia after treatment with infliximab (Remicade) in a German prospective, open-label, multicenter trial in refractory Crohn’s disease.  Am J Gastroenterol. 2002;  97 2688-2690
  • 474 Kaufman I, Caspi D, Yeshurun D. et al . The effect of infliximab on extraintestinal manifestations of Crohn’s disease.  Rheumatol Int. 2005;  25 406-410
  • 475 Rispo A, Scarpa R, Di Girolamo E. et al . Infliximab in the treatment of extra-intestinal manifestations of Crohn’s disease.  Scand J Rheumatol. 2005;  34 387-391
  • 476 Erlichman M, Holohan T V. Bone densitometry: patients receiving prolonged steroid therapy.  Health Technol Assess (Rockv). 1996;  i-31
  • 477 Ahmed S F, Horrocks I A, Patterson T. et al . Bone mineral assessment by dual energy X-ray absorptiometry in children with inflammatory bowel disease: evaluation by age or bone area.  J Pediatr Gastroenterol Nutr. 2004;  38 276-280
  • 478 Burnham J M, Shults J, Semeao E. et al . Whole body BMC in pediatric Crohn disease: independent effects of altered growth, maturation, and body composition.  J Bone Miner Res. 2004;  19 1961-1968
  • 479 Fewtrell M S. Bone densitometry in children assessed by dual × ray absorptiometry: uses and pitfalls.  Arch Dis Child. 2003;  88 795-798
  • 480 Tirpitz von C, Klaus J, Steinkamp M. et al . Therapy of osteoporosis in patients with Crohn’s disease: a randomized study comparing sodium fluoride and ibandronate.  Aliment Pharmacol Ther. 2003;  17 807-816
  • 481 Compston J E. Emerging consensus on prevention and treatment of glucocorticoid-induced osteoporosis.  Curr Rheumatol Rep. 2007;  9 78-84
  • 482 Bartram S A, Peaston R T, Rawlings D J. et al . A randomized controlled trial of calcium with vitamin D, alone or in combination with intravenous pamidronate, for the treatment of low bone mineral density associated with Crohn’s disease.  Aliment Pharmacol Ther. 2003;  18 1121-1127
  • 483 Siffledeen J S, Fedorak R N, Siminoski K. et al . Randomized trial of etidronate plus calcium and vitamin D for treatment of low bone mineral density in Crohn’s disease.  Clin Gastroenterol Hepatol. 2005;  3 122-132
  • 484 Requena L, Sanchez Yus E. Erythema nodosum.  Semin Cutan Med Surg. 2007;  26 114-125
  • 485 Gregory B, Ho V C. Cutaneous manifestations of gastrointestinal disorders. Part II.  J Am Acad Dermatol. 1992;  26 371-383
  • 486 Kirsch B. et al . Dermatosen bei chronisch entzündlichen Darmerkrankungen. Ergebnisse einer Untersuchung von 119 Morbus Crohn/C. ulcerosa-Patienten.  Akt Dermatol. 1992;  18 17-22
  • 487 Blitz N M, Rudikoff D. Pyoderma gangrenosum.  Mt Sinai J Med. 2001;  68 287-297
  • 488 Juillerat P, Mottet C, Froehlich F. et al . Extraintestinal manifestations of Crohn’s disease.  Digestion. 2005;  71 31-36
  • 489 Requena L, Requena C. Erythema nodosum.  Dermatol Online J. 2002;  8 4
  • 490 Matis W L, Ellis C N, Griffiths C E. et al . Treatment of pyoderma gangrenosum with cyclosporine.  Arch Dermatol. 1992;  128 1060-1064
  • 491 Jolles S, Niclasse S, Benson E. Combination oral and topical tacrolimus in therapy-resistant pyoderma gangrenosum.  Br J Dermatol. 1999;  140 564-565
  • 492 Brooklyn T N, Dunnill M G, Shetty A. et al . Infliximab for the treatment of pyoderma gangrenosum: a randomised, double blind, placebo controlled trial.  Gut. 2006;  55 505-509
  • 493 Mintz R, Feller E R, Bahr R L. et al . Ocular manifestations of inflammatory bowel disease.  Inflamm Bowel Dis. 2004;  10 135-139
  • 494 Berstad A E, Aabakken L, Smith H J. et al . Diagnostic accuracy of magnetic resonance and endoscopic retrograde cholangiography in primary sclerosing cholangitis.  Clin Gastroenterol Hepatol. 2006;  4 514-520
  • 495 Moff S L, Kamel I R, Eustace J. et al . Diagnosis of primary sclerosing cholangitis: a blinded comparative study using magnetic resonance cholangiography and endoscopic retrograde cholangiography.  Gastrointest Endosc. 2006;  64 219-223
  • 496 Rosch T, Meining A, Fruhmorgen S. et al . A prospective comparison of the diagnostic accuracy of ERCP, MRCP, CT, and EUS in biliary strictures.  Gastrointest Endosc. 2002;  55 870-876
  • 497 Textor H J, Flacke S, Pauleit D. et al . Three-dimensional magnetic resonance cholangiopancreatography with respiratory triggering in the diagnosis of primary sclerosing cholangitis: comparison with endoscopic retrograde cholangiography.  Endoscopy. 2002;  34 984-990
  • 498 Burak K W, Angulo P, Lindor K D. Is there a role for liver biopsy in primary sclerosing cholangitis?.  Am J Gastroenterol. 2003;  98 1155-1158
  • 499 Bergquist A, Ekbom A, Olsson R. et al . Hepatic and extrahepatic malignancies in primary sclerosing cholangitis.  J Hepatol. 2002;  36 321-327
  • 500 Broome U, Olsson R, Loof L. et al . Natural history and prognostic factors in 305 Swedish patients with primary sclerosing cholangitis.  Gut. 1996;  38 610-615
  • 501 Harnois D M, Angulo P, Jorgensen R A. et al . High-dose ursodeoxycholic acid as a therapy for patients with primary sclerosing cholangitis.  Am J Gastroenterol. 2001;  96 1558-1562
  • 502 Lee J G, Schutz S M, England R E. et al . Endoscopic therapy of sclerosing cholangitis.  Hepatology. 1995;  21 661-667
  • 503 Mitchell S A, Bansi D S, Hunt N. et al . A preliminary trial of high-dose ursodeoxycholic acid in primary sclerosing cholangitis.  Gastroenterology. 2001;  121 900-907
  • 504 Stiehl A, Rudolph G, Kloters-Plachky P. et al . Development of dominant bile duct stenoses in patients with primary sclerosing cholangitis treated with ursodeoxycholic acid: outcome after endoscopic treatment.  J Hepatol. 2002;  36 151-156
  • 505 Stiehl A, Rudolph G, Sauer P. et al . Efficacy of ursodeoxycholic acid treatment and endoscopic dilation of major duct stenoses in primary sclerosing cholangitis. An 8-year prospective study.  J Hepatol. 1997;  26 560-566
  • 506 Stiehl A, Walker S, Stiehl L. et al . Effect of ursodeoxycholic acid on liver and bile duct disease in primary sclerosing cholangitis. A 3-year pilot study with a placebo-controlled study period.  J Hepatol. 1994;  20 57-64
  • 507 Pardi D S, Loftus E V, Kremers W K. et al . Ursodeoxycholic acid as a chemopreventive agent in patients with ulcerative colitis and primary sclerosing cholangitis.  Gastroenterology. 2003;  124 889-893
  • 508 Rudolph Jr G, Kloeters-Plachky P, Rost D. et al . The incidence of cholangiocarcinoma in primary sclerosing cholangitis after long-time treatment with ursodeoxycholic acid.  Eur J Gastroenterol Hepatol. 2007;  19 487-491
  • 509 Tung B Y, Emond M J, Haggitt R C. et al . Ursodiol use is associated with lower prevalence of colonic neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis.  Ann Intern Med. 2001;  134 89-95
  • 510 Loftus E V. Management of extraintestinal manifestations and other complications of inflammatory bowel disease.  Curr Gastroenterol Rep. 2004;  6 506-513
  • 511 Andrews Jr H, Barczak P, Allan R N. Psychiatric illness in patients with inflammatory bowel disease.  Gut. 1987;  28 1600-1604
  • 512 Clouse R E, Alpers D H. The relationship of psychiatric disorder to gastrointestinal illness.  Annu Rev Med. 1986;  37 283-295
  • 513 Drossman D A, Leserman J, Li Z M. et al . The rating form of IBD patient concerns: a new measure of health status.  Psychosom Med. 1991;  53 701-712
  • 514 Guthrie E, Jackson J, Shaffer J. et al . Psychological disorder and severity of inflammatory bowel disease predict health-related quality of life in ulcerative colitis and Crohn’s disease.  Am J Gastroenterol. 2002;  97 1994-1999
  • 515 Helzer J E, Chammas S, Norland C C. et al . A study of the association between Crohn’s disease and psychiatric illness.  Gastroenterology. 1984;  86 324-330
  • 516 Kurina L M, Goldacre M J, Yeates D. et al . Depression and anxiety in people with inflammatory bowel disease.  J Epidemiol Community Health. 2001;  55 716-720
  • 517 Nordin K, Pahlman L, Larsson K. et al . Health-related quality of life and psychological distress in a population-based sample of Swedish patients with inflammatory bowel disease.  Scand J Gastroenterol. 2002;  37 450-457
  • 518 Tarter R E, Switala J, Carra J. et al . Inflammatory bowel disease: psychiatric status of patients before and after disease onset.  Int J Psychiatry Med. 1987;  17 173-181
  • 519 Fuller-Thomson E, Sulman J. Depression and inflammatory bowel disease: findings from two nationally representative Canadian surveys.  Inflamm Bowel Dis. 2006;  12 697-707
  • 520 Mussell M, Bocker U, Nagel N. et al . Predictors of disease-related concerns and other aspects of health-related quality of life in outpatients with inflammatory bowel disease.  Eur J Gastroenterol Hepatol. 2004;  16 1273-1280
  • 521 Farrokhyar F, Marshall J K, Easterbrook B. et al . Functional gastrointestinal disorders and mood disorders in patients with inactive inflammatory bowel disease: prevalence and impact on health.  Inflamm Bowel Dis. 2006;  12 38-46
  • 522 Jones M P, Wessinger S, Crowell M D. Coping strategies and interpersonal support in patients with irritable bowel syndrome and inflammatory bowel disease.  Clin Gastroenterol Hepatol. 2006;  4 474-481
  • 523 Pace F, Molteni P, Bollani S. et al . Inflammatory bowel disease versus irritable bowel syndrome: a hospital-based, case-control study of disease impact on quality of life.  Scand J Gastroenterol. 2003;  38 1031-1038
  • 524 Addolorato G, Capristo E, Stefanini G F. et al . Inflammatory bowel disease: a study of the association between anxiety and depression, physical morbidity, and nutritional status.  Scand J Gastroenterol. 1997;  32 1013-1021
  • 525 Bernklev T, Jahnsen J, Schulz T. et al . Course of disease, drug treatment and health-related quality of life in patients with inflammatory bowel disease 5 years after initial diagnosis.  Eur J Gastroenterol Hepatol. 2005;  17 1037-1045
  • 526 Casellas F, Arenas J I, Baudet J S. et al . Impairment of health-related quality of life in patients with inflammatory bowel disease: a Spanish multicenter study.  Inflamm Bowel Dis. 2005;  11 488-496
  • 527 Casellas F, Lopez-Vivancos J, Badia X. et al . Influence of inflammatory bowel disease on different dimensions of quality of life.  Eur J Gastroenterol Hepatol. 2001;  13 567-572
  • 528 Cohen R D. The quality of life in patients with Crohn’s disease.  Aliment Pharmacol Ther. 2002;  16 1603-1609
  • 529 Gibson P R, Weston A R, Shann A. et al . Relationship between disease severity, quality of life and health-care resource use in a cross-section of Australian patients with Crohn’s disease.  J Gastroenterol Hepatol. 2007;  22 1306-1312
  • 530 Porcelli P, Leoci C, Guerra V. A prospective study of the relationship between disease activity and psychologic distress in patients with inflammatory bowel disease.  Scand J Gastroenterol. 1996;  31 792-796
  • 531 Rubin G P, Hungin A P, Chinn D J. et al . Quality of life in patients with established inflammatory bowel disease: a UK general practice survey.  Aliment Pharmacol Ther. 2004;  19 529-535
  • 532 Saibeni S, Cortinovis I, Beretta L. et al . Gender and disease activity influence health-related quality of life in inflammatory bowel diseases.  Hepatogastroenterology. 2005;  52 509-515
  • 533 Li J, Norgard B, Precht D H. et al . Psychological stress and inflammatory bowel disease: a follow-up study in parents who lost a child in Denmark.  Am J Gastroenterol. 2004;  99 1129-1133
  • 534 Mardini H E, Kip K E, Wilson J W. Crohn’s disease: a two-year prospective study of the association between psychological distress and disease activity.  Dig Dis Sci. 2004;  49 492-497
  • 535 Mittermaier C, Dejaco C, Waldhoer T. et al . Impact of depressive mood on relapse in patients with inflammatory bowel disease: a prospective 18-month follow-up study.  Psychosom Med. 2004;  66 79-84
  • 536 Persoons P, Vermeire S, Demyttenaere K. et al . The impact of major depressive disorder on the short- and long-term outcome of Crohn’s disease treatment with infliximab.  Aliment Pharmacol Ther. 2005;  22 101-110
  • 537 Duffy L C, Zielezny M A, Marshall J R. et al . Relevance of major stress events as an indicator of disease activity prevalence in inflammatory bowel disease.  Behav Med. 1991;  17 101-110
  • 538 Lerebours E, Gower-Rousseau C, Merle V. et al . Stressful life events as a risk factor for inflammatory bowel disease onset: A population-based case-control study.  Am J Gastroenterol. 2007;  102 122-131
  • 539 North C S, Alpers D H, Helzer J E. et al . Do life events or depression exacerbate inflammatory bowel disease? A prospective study.  Ann Intern Med. 1991;  114 381-386
  • 540 Vidal A, Gomez-Gil E, Sans M. et al . Life events and inflammatory bowel disease relapse: a prospective study of patients enrolled in remission.  Am J Gastroenterol. 2006;  101 775-781
  • 541 Wietersheim von J, Overbeck A, Kiel K. et al . The significance of recurrence-inducing events for patients with chronic inflammatory bowel diseases. Results of a prospective longitudinal study over three years.  Psychother Psychosom Med Psychol. 1994;  44 58-64
  • 542 Garrett V D, Brantley P J, Jones G N. et al . The relation between daily stress and Crohn’s disease.  J Behav Med. 1991;  14 87-96
  • 543 Greene B R, Blanchard E B, Wan C K. Long-term monitoring of psychosocial stress and symptomatology in inflammatory bowel disease.  Behav Res Ther. 1994;  32 217-226
  • 544 Litcher-Kelly L, Stone A. Recall and momentary assessments of two self-report items from the Crohn’s Disease Activity Index (CDAI).  Psychosom Med. 2005;  A-75 1621
  • 545 Moser G, Genser D, Tribl B. et al . Psychological stress and disease activity in ulcerative colitis: a multidimensional cross-sectional study.  Am J Gastroenterol. 1995;  90 1904
  • 546 Gomez-Gil E, Vidal A, Panes J. et al . Relationship between patient’s subjective stress perception and the course of inflammatory bowel disease.  Gastroenterol Hepatol. 2003;  26 411-416
  • 547 Nigro G, Angelini G, Grosso S B. et al . Psychiatric predictors of noncompliance in inflammatory bowel disease: psychiatry and compliance.  J Clin Gastroenterol. 2001;  32 66-68
  • 548 Robertson D A, Ray J, Diamond I. et al . Personality profile and affective state of patients with inflammatory bowel disease.  Gut. 1989;  30 623-626
  • 549 Farhadi A, Keshavarzian A, Van de Kar L D. et al . Heightened responses to stressors in patients with inflammatory bowel disease.  Am J Gastroenterol. 2005;  100 1796-1804
  • 550 Bernklev T, Jahnsen J, Henriksen M. et al . Relationship between sick leave, unemployment, disability, and health-related quality of life in patients with inflammatory bowel disease.  Inflamm Bowel Dis. 2006;  12 402-412
  • 551 Drossman D A, Leserman J, Mitchell C M. et al . Health status and health care use in persons with inflammatory bowel disease. A national sample.  Dig Dis Sci. 1991;  36 1746-1755
  • 552 Deter H C, Keller W, Wietersheim von J. et al . Psychological treatment may reduce the need for healthcare in patients with Crohn’s disease.  Inflamm Bowel Dis. 2007;  13 745-752
  • 553 Timmer A, Bauer A, Dignass A. et al . Sexual function in persons with inflammatory bowel disease: a survey with matched controls.  Clin Gastroenterol Hepatol. 2007;  5 87-94
  • 554 Timmer A, Bauer A, Kemptner D. et al . Determinants of male sexual function in inflammatory bowel disease: a survey-based cross-sectional analysis in 280 men.  Inflamm Bowel Dis. 2007;  13 1236-1243
  • 555 De Boer M, Grootenhuis M, Derkx B. et al . Health-related quality of life and psychosocial functioning of adolescents with inflammatory bowel disease.  Inflamm Bowel Dis. 2005;  11 400-406
  • 556 Sewitch M J, Abrahamowicz M, Bitton A. et al . Psychosocial correlates of patient-physician discordance in inflammatory bowel disease.  Am J Gastroenterol. 2002;  97 2174-2183
  • 557 Wietersheim von J, Jantschek G, Sommer W. et al . Education of patients with inflammatory bowel diseases.  Wien Med Wochenschr. 1999;  149 352-354
  • 558 Moser G, Tillinger W, Sachs G. et al . Disease-related worries and concerns: a study on out-patients with inflammatory bowel disease.  Eur J Gastroenterol Hepatol. 1995;  7 853-858
  • 559 Kennedy A, Nelson E, Reeves D. et al . A randomised controlled trial to assess the impact of a package comprising a patient-orientated, evidence-based self-help guidebook and patient-centred consultations on disease management and satisfaction in inflammatory bowel disease.  Health Technol Assess. 2003;  7 iii, 1-113
  • 560 Kennedy A P, Nelson E, Reeves D. et al . A randomised controlled trial to assess the effectiveness and cost of a patient orientated self management approach to chronic inflammatory bowel disease.  Gut. 2004;  53 1639-1645
  • 561 Borgaonkar M R, Townson G, Donnelly M. et al . Providing disease-related information worsens health-related quality of life in inflammatory bowel disease.  Inflamm Bowel Dis. 2002;  8 264-269
  • 562 Lange A, Haslbeck E, Andus T. et al . Ambulatory education of patient with Crohn disease/ulcerative colitis.  Z Gastroenterol. 1996;  34 411-415
  • 563 Larsson K, Sundberg Hjelm M, Karlbom U. et al . A group-based patient education programme for high-anxiety patients with Crohn disease or ulcerative colitis.  Scand J Gastroenterol. 2003;  38 763-769
  • 564 Bregenzer N, Lange A, Furst A. et al . Patient education in inflammatory bowel disease does not influence patients knowledge and long-term psychosocial well-being.  Z Gastroenterol. 2005;  43 367-371
  • 565 Irvine E J, Zhou Q, Thompson A K. The Short Inflammatory Bowel Disease Questionnaire: a quality of life instrument for community physicians managing inflammatory bowel disease. CCRPT Investigators. Canadian Crohn’s Relapse Prevention Trial.  Am J Gastroenterol. 1996;  91 1571-1578
  • 566 Janke K, Steder-Neukamm U, Bauer M. Quality of life assessment in Inflammatory Bowel Disease (IBD): German version of the Inflammatory Bowel Disease Questionnaire (IBDQ-D; disease specific intrument for quality of life assessment) – first application and comparison with international investigations.  Gesundheitswesen. 2005;  67 656-664
  • 567 Janke K H, Klump B, Steder-Neukamm U. et al . Validation of the German version of the Inflammatory Bowel Disease Questionnaire (Competence Network IBD, IBDQ-D).  Psychother Psychosom Med Psychol. 2006;  56 291-298
  • 568 Rose M, Fliege H, Hildebrandt M. et al . Validation of the new German translation version of the „Short Inflammatory Bowel Disease Questionnaire” (SIBDQ).  Z Gastroenterol. 2000;  38 277-286
  • 569 Stjernman H, Granno C, Jarnerot G. et al . Short health scale: A valid, reliable, and responsive instrument for subjective health assessment in Crohn’s disease.  Inflamm Bowel Dis. 2008;  14 47-52
  • 570 Boer A G, Sprangers M A, Bartelsman J F. et al . Predictors of health care utilization in patients with inflammatory bowel disease: a longitudinal study.  Eur J Gastroenterol Hepatol. 1998;  10 783-789
  • 571 Miehsler de W, Weichselberger M, Offerlbauer-Ernst A. et al . Assessing the demand for psychological care in chronic diseases: development and validation of a questionnaire based on the example of inflammatory bowel disease.  Inflamm Bowel Dis. 2004;  10 637-645
  • 572 Miehsler W, Dejaco C, Moser G. Factor analysis of ADAPT questionnaire for assessment of subjective need for psychological interventions.  Inflamm Bowel Dis. 2008;  14 142-143
  • 573 Kunzendorf S, Jantschek G, Straubinger K. et al . The Luebeck interview for psychosocial screening in patients with inflammatory bowel disease.  Inflamm Bowel Dis. 2007;  13 33-41
  • 574 Sewitch M J, Abrahamowicz M, Bitton A. et al . Psychological distress, social support, and disease activity in patients with inflammatory bowel disease.  Am J Gastroenterol. 2001;  96 1470-1479
  • 575 Caprilli R, Gassull M A, Escher J C. et al . European evidence based consensus on the diagnosis and management of Crohn’s disease: special situations.  Gut. 2006;  55 Suppl 1 i36-58
  • 576 Stange E F, Schreiber S, Folsch U R. et al . Diagnostics and treatment of Crohn’s disease – results of an evidence-based consensus conference of the German Society for Digestive and Metabolic Diseases.  Z Gastroenterol. 2003;  41 19-20
  • 577 Casellas F, Fontanet G, Borruel N. et al . The opinion of patients with inflammatory bowel disease on healthcare received.  Rev Esp Enferm Dig. 2004;  96 174-184
  • 578 Leshem R N. Inflammatory bowel disease support groups: a primer for gastroenterology nurses.  Gastroenterol Nurs. 2003;  26 246-250
  • 579 Luttenberger H. The German Crohn Disease/Ulcerative Colitis Society: experiences in the self-help group.  Z Gastroenterol. 1996;  34 Suppl 2 64-65
  • 580 Moody G A, Bhakta P, Mayberry J F. Disinterest in local self-help groups amongst patients with inflammatory bowel disease in Leicester.  Int J Colorectal Dis. 1993;  8 181-183
  • 581 Joachim G. The birth and dissolution of an inflammatory bowel disease support group: lessons in providing support.  Gastroenterol Nurs. 1998;  21 119-124
  • 582 Shepanski M A, Hurd L B, Culton K. et al . Health-related quality of life improves in children and adolescents with inflammatory bowel disease after attending a camp sponsored by the Crohn’s and Colitis Foundation of America.  Inflamm Bowel Dis. 2005;  11 164-170
  • 583 Takacs L F, Kollman C E. An inflammatory bowel disease support group for teens and their parents.  Gastroenterol Nurs. 1994;  17 11-13
  • 584 Oliveira S, Zaltman C, Elia C. et al . Quality-of-life measurement in patients with inflammatory bowel disease receiving social support.  Inflamm Bowel Dis. 2007;  13 470-474
  • 585 Milne B, Joachim G, Niedhardt J. A stress management programme for inflammatory bowel disease patients.  J Adv Nurs. 1986;  11 561-567
  • 586 Mussell M, Bocker U, Nagel N. et al . Reducing psychological distress in patients with inflammatory bowel disease by cognitive-behavioural treatment: exploratory study of effectiveness.  Scand J Gastroenterol. 2003;  38 755-762
  • 587 Schwarz S P, Blanchard E B. Evaluation of a psychological treatment for inflammatory bowel disease.  Behav Res Ther. 1991;  29 167-177
  • 588 Szigethy E, Kenney E, Carpenter J. et al . Cognitive-behavioral therapy for adolescents with inflammatory bowel disease and subsyndromal depression.  J Am Acad Child Adolesc Psychiatry. 2007;  46 1290-1298
  • 589 Jantschek G, Zeitz M, Pritsch M. et al . Effect of psychotherapy on the course of Crohn’s disease. Results of the German prospective multicenter psychotherapy treatment study on Crohn’s disease. German Study Group on Psychosocial Intervention in Crohn’s Disease.  Scand J Gastroenterol. 1998;  33 1289-1296
  • 590 Keller W, Pritsch M, Von Wietersheim J. et al . Effect of psychotherapy and relaxation on the psychosocial and somatic course of Crohn’s disease: main results of the German Prospective Multicenter Psychotherapy Treatment study on Crohn’s Disease.  J Psychosom Res. 2004;  56 687-696
  • 591 Maunder R G, Esplen M J. Supportive-expressive group psychotherapy for persons with inflammatory bowel disease.  Can J Psychiatry. 2001;  46 622-626
  • 592 Wietersheim von J, Kessler H. Psychotherapy with chronic inflammatory bowel disease patients: a review.  Inflamm Bowel Dis. 2006;  12 1175-1184
  • 593 Garcia-Vega E, Fernandez-Rodriguez C. A stress management programme for Crohn’s disease.  Behav Res Ther. 2004;  42 367-383
  • 594 Mickoka-Wallus A, Turnbull D, Moulding N. et al . Antidepressants and inflammatory bowel disease: a systematic review.  Clin Pract Epidemiol Ment Health. 2006;  2 24-32
  • 595 Hilsden R J, Hodgins D C, Timmer A. et al . Helping patients with Crohn’s disease quit smoking.  Am J Gastroenterol. 2000;  95 352-358
  • 596 Hilsden R J, Hodgins D, Czechowsky D. et al . Attitudes toward smoking and smoking behaviors of patients with Crohn’s disease.  Am J Gastroenterol. 2001;  96 1849-1853
  • 597 Cosnes J, Beaugerie L, Carbonnel F. et al . Smoking cessation and the course of Crohn’s disease: an intervention study.  Gastroenterology. 2001;  120 1093-1099
  • 598 Johnson G J, Cosnes J, Mansfield J C. Review article: smoking cessation as primary therapy to modify the course of Crohn’s disease.  Aliment Pharmacol Ther. 2005;  21 921-931
  • 599 Lancaster T, Stead L. Physician advice for smoking cessation.  Cochrane Database Syst Rev. 2004;  CD000165
  • 600 Lancaster T, Stead L F. Individual behavioural counselling for smoking cessation.  Cochrane Database Syst Rev. 2005;  CD001292
  • 601 Gailhoustet L, Goulet O, Cachin N. et al . Study of psychological repercussions of 2 modes of treatment of adolescents with Crohn’s disease.  Arch Pediatr. 2002;  9 110-116
  • 602 Engstrom I. Parental distress and social interaction in families with children with inflammatory bowel disease.  J Am Acad Child Adolesc Psychiatry. 1991;  30 904-912
  • 603 Day A S, Whitten K E, Bohane T D. Childhood inflammatory bowel disease: parental concerns and expectations.  World J Gastroenterol. 2005;  11 1028-1031
  • 604 Engstrom I. Family interaction and locus of control in children and adolescents with inflammatory bowel disease.  J Am Acad Child Adolesc Psychiatry. 1991;  30 913-920
  • 605 Mackner L M, Crandall W V. Long-term psychosocial outcomes reported by children and adolescents with inflammatory bowel disease.  Am J Gastroenterol. 2005;  100 1386-1392
  • 606 Mackner L M, Crandall W V, Szigethy E M. Psychosocial functioning in pediatric inflammatory bowel disease.  Inflamm Bowel Dis. 2006;  12 239-244
  • 607 Gold N, Issenman R, Roberts J. et al . Well-adjusted children: an alternate view of children with inflammatory bowel disease and functional gastrointestinal complaints.  Inflamm Bowel Dis. 2000;  6 1-7
  • 608 Mackner L M, Crandall W V. Oral medication adherence in pediatric inflammatory bowel disease.  Inflamm Bowel Dis. 2005;  11 1006-1012
  • 609 Szigethy E, Levy-Warren A, Whitton S. et al . Depressive symptoms and inflammatory bowel disease in children and adolescents: a cross-sectional study.  J Pediatr Gastroenterol Nutr. 2004;  39 395-403
  • 610 Zaag-Loonen H J, Grootenhuis M A, Last B F. et al . Coping strategies and quality of life of adolescents with inflammatory bowel disease.  Qual Life Res. 2004;  13 1011-1019
  • 611 Hilsden R J, Meddings J B, Verhoef M J. Complementary and alternative medicine use by patients with inflammatory bowel disease: An Internet survey.  Can J Gastroenterol. 1999;  13 327-332
  • 612 Hilsden R J, Scott C M, Verhoef M J. Complementary medicine use by patients with inflammatory bowel disease.  Am J Gastroenterol. 1998;  93 697-701
  • 613 Hilsden R J, Verhoef M J, Best van der A. et al . Complementary and alternative medicine use by Canadian patients with inflammatory bowel disease: results from a national survey.  Am J Gastroenterol. 2003;  98 1563-1568
  • 614 Langhorst J, Anthonisen I, Steder-Neukamm U. et al . Einsatz komplementärmedizinischer Therapieverfahren bei Patienten mit chronisch entzündlichen Darmerkrankungen in Deutschland.  Z Gastroenterologie. 2002;  8 641
  • 615 Langhorst J, Anthonisen I B, Steder-Neukamm U. et al . Amount of systemic steroid medication is a strong predictor for the use of complementary and alternative medicine in patients with inflammatory bowel disease: results from a German national survey.  Inflamm Bowel Dis. 2005;  11 287-295
  • 616 Langmead L, Chitnis M, Rampton D S. Use of complementary therapies by patients with IBD may indicate psychosocial distress.  Inflamm Bowel Dis. 2002;  8 174-179
  • 617 Moser G, Tillinger W, Sachs G. et al . Relationship between the use of unconventional therapies and disease-related concerns: a study of patients with inflammatory bowel disease.  J Psychosom Res. 1996;  40 503-509
  • 618 Hilsden R J, Verhoef M J. Complementary and alternative medicine: evaluating its effectiveness in inflammatory bowel disease.  Inflamm Bowel Dis. 1998;  4 318-323
  • 619 Groenewold M, Bücker B, Kohlhammer Y. et al . Costs, quality of life and health behaviour in CAM: results of a telephone survey of 1001 adults in Germany.  Focus on alternative and complementary Therapies. 2005;  10 22
  • 620 Markowitz J E, Mamula P, delRosario J F. et al . Patterns of complementary and alternative medicine use in a population of pediatric patients with inflammatory bowel disease.  Inflamm Bowel Dis. 2004;  10 599-605
  • 621 World Health Organisation .WHO Guidelines on developing consumer information on proper use of traditional, complementary and alternative medicine. World Health Organization 2004
  • 622 Bücker B. Alternative Verfahren in der Medizin; Muster der Inanspruchnahme bei Lübecker Erwachsenen und Kindern. Inauguraldissertation zur Erlangung der Doktorwürde an der Universitüt Lübeck 2006 1.116
  • 623 Matthes H. Complementary therapies.  Z Gastroenterol. 2003;  41 52-53
  • 624 Matthes H. Alternative Therapien bei CED. Hoffmann Jr C, Klump B, Kroesen A Sas CED-Manual Stuttgart; Thieme 2003: 199-203
  • 625 Pschyrembel Klinisches Wörterbuch. Berlin, New York; de Gruyter 2004 260 Aufl
  • 626 Linde K, Melchert D. Komplementärmedizin in der Cochrane Collaboration – Chancen und Risiken. Hornung J Forschungsmethoden in der Komplementärmedizin Über die Notwendigkeit eine methodologischen Erneuerung Schattauer 1996: 225
  • 627 Moher D, Schulz K F, Altman D. The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials.  Jama. 2001;  285 1987-1991
  • 628 Benson K, Hartz A J. A comparison of observational studies and randomized, controlled trials.  N Engl J Med. 2000;  342 1878-1886
  • 629 Concato J, Shah N, Horwitz R I. Randomized, controlled trials, observational studies, and the hierarchy of research designs.  N Engl J Med. 2000;  342 1887-1892
  • 630 Joos S, Rosemann T, Szecsenyi J. et al . Use of complementary and alternative medicine in Germany – a survey of patients with inflammatory bowel disease.  BMC Complement Altern Med. 2006;  6 19
  • 631 Kong S C, Hurlstone D P, Pocock C Y. et al . The Incidence of self-prescribed oral complementary and alternative medicine use by patients with gastrointestinal diseases.  J Clin Gastroenterol. 2005;  39 138-141
  • 632 Langmead L, Rampton D S. Review article: complementary and alternative therapies for inflammatory bowel disease.  Aliment Pharmacol Ther. 2006;  23 341-349
  • 633 Day A S, Whitten K E, Bohane T D. Use of complementary and alternative medicines by children and adolescents with inflammatory bowel disease.  J Paediatr Child Health. 2004;  40 681-684
  • 634 Heuschkel R, Afzal N, Wuerth A. et al . Complementary medicine use in children and young adults with inflammatory bowel disease.  Am J Gastroenterol. 2002;  97 382-388
  • 635 McCann L J, Newell S J. Survey of paediatric complementary and alternative medicine use in health and chronic illness.  Arch Dis Child. 2006;  91 173-174
  • 636 Ausfeld-Hafter B, Hoffmann S, Seibold F. et al . Status of alternative medicine in Crohn disease and ulcerative colitis patents: a questionnaire survey.  Forsch Komplementarmed Klass Naturheilkd. 2005;  12 134-138
  • 637 Binder V. Prognosis and quality of life in patients with ulcerative colitis and Crohn’s disease.  Int Disabil Stud. 1988;  10 172-174
  • 638 Leong R W, Lawrance I C, Ching J Y. et al . Knowledge, quality of life, and use of complementary and alternative medicine and therapies in inflammatory bowel disease: a comparison of Chinese and Caucasian patients.  Dig Dis Sci. 2004;  49 1672-1676
  • 639 Quattropani C, Ausfeld B, Straumann A. et al . Complementary alternative medicine in patients with inflammatory bowel disease: use and attitudes.  Scand J Gastroenterol. 2003;  38 277-282
  • 640 Joos S, Brinkhaus B, Maluche C. et al . Acupuncture and moxibustion in the treatment of active Crohn’s disease: a randomized controlled study.  Digestion. 2004;  69 131-139
  • 641 Belluzzi A, Brignola C, Campieri M. et al . Effect of an enteric-coated fish-oil preparation on relapses in Crohn’s disease.  N Engl J Med. 1996;  334 1557-1560
  • 642 Chawla A, Karl P I, Fisher S E. Effect of N-3 polyunsaturated fatty acid supplemented diet on neutrophil-mediated ileal permeability and neutrophil function in the rat.  J Am Coll Nutr. 1995;  14 258-263
  • 643 Shoda R, Matsueda K, Yamato S. et al . Therapeutic efficacy of N-3 polyunsaturated fatty acid in experimental Crohn’s disease.  J Gastroenterol. 1995;  30 98-101
  • 644 Yuceyar H, Ozutemiz O, Huseyinov A. et al . Is administration of n-3 fatty acids by mucosal enema protective against trinitrobenzene-induced colitis in rats?.  Prostaglandins Leukot Essent Fatty Acids. 1999;  61 339-345
  • 645 Nakazawa A, Hibi T. Is fish oil (n-3 fatty acids) effective for the maintenance of remission in Crohn’s disease?.  J Gastroenterol. 2000;  35 173-175
  • 646 Gerhardt H, Seifert F, Buvari P. et al . Therapy of active Crohn disease with Boswellia serrata extract H 15.  Z Gastroenterol. 2001;  39 11-17
  • 647 Summers R W, Elliott D E, Urban J F. et al . Trichuris suis therapy in Crohn’s disease.  Gut. 2005;  54 87-90
  • 648 Kradin R L, Badizadegan Jr K, Auluck P. et al . Iatrogenic Trichuris suis infection in a patient with Crohn disease.  Arch Pathol Lab Med. 2006;  130 718-720
  • 649 Kruis W, Schutz E, Fric P. et al . Double-blind comparison of an oral Escherichia coli preparation and mesalazine in maintaining remission of ulcerative colitis.  Aliment Pharmacol Ther. 1997;  11 853-858
  • 650 Rembacken B J, Snelling A M, Hawkey P M. et al . Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial.  Lancet. 1999;  354 635-639
  • 651 Rolfe V E, Fortun P J, Hawkey C J. et al . Probiotics for maintenance of remission in Crohn’s disease.  Cochrane Database Syst Rev. 2006;  CD004826
  • 652 Malchow H A. Crohn’s disease and Escherichia coli. A new approach in therapy to maintain remission of colonic Crohn’s disease?.  J Clin Gastroenterol. 1997;  25 653-658

1 Mitgetragen durch die

1 Deutsche Gesellschaft für Allgemein- und Viszeralchirurgie

1 Deutsche Gesellschaft für Chirurgie

1 Deutsche Gesellschaft für Ernährungsmedizin

1 Deutsche Gesellschaft für Innere Medizin

1 Deutsches Kollegium für Psychosomatische Medizin

1 Deutsche Gesellschaft für Koloproktologie

1 Gesellschaft für Pädiatrische Gastroenterologie und Ernährung

1 Deutsche Gesellschaft für Pathologie.

1 Unter Mitarbeit der Deutschen Morbus Crohn/Colitis ulcerosa Vereinigung – DCCV e.V.

1 Die Leitlinie wurde erarbeitet mit Unterstützung des Leitlinien-Entwicklungsportals www.leitlinienentwicklung.de, einem gemeinsamen Forschungsprojekt der Charité – Universitätsmedizin und der Telematikplattform für Medizinische Forschungsnetze (TMF) e. V.

2 Koordinationskommitee.

3 Beide Autoren trugen gleichwertig zu dieser Arbeit bei.

Priv.-Doz. Dr. J. C. Hoffmann

Medizinische Klinik I mit Schwerpunkt Gastroenterologie, Diabetologie, Rheumatologie und Onkologie, St. Marienkrankenhaus

Salzburger Str. 15

67067 Ludwigshafen

Phone: ++ 49/6 21/55 01 22 32

Fax: ++ 49/6 21/55 01 27 95

Email: joerg.hoffmann@st-marienkrankenhaus.de