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Am J Perinatol 1987; 4(1): 41-49
DOI: 10.1055/s-2007-999735
DOI: 10.1055/s-2007-999735
ORIGINAL ARTICLE
© 1987 by Thieme Medical Publishers, Inc.
Criteria for the Prenatal Diagnosis of Holoprosencephaly
Further Information
Publication History
Publication Date:
04 March 2008 (online)
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ABSTRACT
Holoprosencephaly is a congenital anomaly of the central nervous system whose prenatal sonographic appearance may to similar to that of ventriculomegaly. A clear differential diagnosis is extremely important because the two conditions have different prognoses and therefore require different obstetric management. Eight cases of prenatally recognized holoprosencephaly are analyzed and criteria for a specific diagnosis proposed. The specificity and limitations of ultrasound findings, such as identification of a holoventricle, presence of a dorsal sac, and facial anomalies are discussed.