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Am J Perinatol 1991; 8(2): 106-109
DOI: 10.1055/s-2007-999356
ORIGINAL ARTICLE

© 1991 by Thieme Medical Publishers, Inc.

Histocompatibility Antigen Subtypes in Black Women with Class A1 or Class GB Diabetes Mellitus

Carey L. Winkler, J. Martin Tucker, John C. Hauth, Robert L. Goldenberg, Ronald T. Acton, Bruce O. Barger, Rodney C.P. Go, David S.H. Bell, Laura L. Perkins, Chotip J. Vanichanan, Jeffrey M. Roseman
  • The Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology; Department of Microbiology; Department of Epidemiology and Center for Health Risk Assessment and Disease Prevention; and Division of Endocrinology, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama
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Publikationsdatum:
04. März 2008 (online)

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ABSTRACT

Insulin-dependent diabetes mellitus is associated with an increased frequency of certain histocompatibility antigens located on chromosome six, the most common types being B-8, B-15, DR-3, DR-4, and DR-7. We therefore theorized that screening for these subtypes may allow the identification of those women with gestational diabetes who will remain euglycemic on dietary modification (class A1) compared with those who will require insulin to achieve euglycemia (class GB). From 1982 to 1987, 228 black women with gestational diabetes were screened for the above histocompatibility antigens. As theorized, certain histocompatibility antigen subtypes were more common in women with class GB gestational diabetes mellitus; DR-2 (41.8% versus 23.7% p = 0.015), B-15 (p = 0.07), and DR-3 (p = 0.08). However, because of the low sensitivity (42%), specificity (75%), and positive predictive value (36%), this test is impractical in the clinical management of women with gestational diabetes mellitus.