Subscribe to RSS
DOI: 10.1055/s-2007-995833
The Role of Secondary Growth Factor Production in Thrombin-lnduced Proliferation of Vascular Smooth Muscle Cells
Publication History
Publication Date:
06 February 2008 (online)
![](https://www.thieme-connect.de/media/sth/199802/lookinside/thumbnails/10.1055-s-2007-995833-1.jpg)
Abstract
α-Thrombin is a multifunctional serine proteinase that is concentrated at sites of vascular injury and has been implicated in vascular healing responses following balloon injury. In addition to its well-known hemostatic effects, thrombin stimulates smooth muscle cell (SMC) proliferation via binding of protease activated receptor-1 (PAR-1), a seven transmembrane, G-protein-coupled cell surface receptor. Following activation of this receptor, SMC produce and secrete various autocrine growth factors, including platelet-derived growth factor-AA (PDGF-AA), basic fibroblast growth factor (bFGF), heparin binding epidermal growth factor (HBEGF), and transforming growth factor-β (TGFβ). The role that autocrine growth factors play in α-thrombin-induced proliferation will be discussed in this review.
Keywords:
Restenosis - smooth muscle - angioplasty - growth factors - thrombin