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DOI: 10.1055/s-2007-994069
© 1998 by Thieme Medical Publishers, Inc.
Coagulation and Fibrinolysis Parameters in Normal Pregnancy and in Gestational Diabetes
Publikationsverlauf
Publikationsdatum:
04. März 2008 (online)
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ABSTRACT
The changes in coagulation and fibrinolysis parameters during pregnancy, delivery and 3 days after delivery were evaluated in normotensive and gestational diabetes pregnant women. Normal pregnant women (n = 60) and pregnant women with gestational diabetes (n = 15) formed the study population. Coagulation and fibrinolysis parameters were estimated using commercial tests. Antithrombin III, thrombin-antithrombin III complexes, heparin cofactor II, protein C, protein S, tissue plasminogen activator, (t-PA) D-dimer and plasminogen activator inhibitor (PAI-1 and PAI-2) activities in normal and gestational diabetes pregnancies were determined. Thrombin-antithrombin III complexes increased and coagulation inhibitors decreased in gestational diabetes. Plasminogen activator inhibitors remained unchanged and t-PA levels increased in gestational diabetes.
Keywords
Coagulation - fibrinolysis - pregnancy - diabetes