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DOI: 10.1055/s-2007-993041
Alkoholbezogene Störungen im Alter - Aktueller Stand zu Diagnostik und Therapie
Unhealthy Alcohol Use in the Elderly - Current Screening and Treatment StrategiesPublication History
Publication Date:
06 February 2008 (online)
Zusammenfassung
Aufgrund des demografischen Wandels und der veränderten Konsumgewohnheiten der jetzt alternden Kohorte ist mit einem Anstieg der Prävalenz alkoholbezogener Störungen im Alter zu rechnen. Konservative Schätzungen gehen für Deutschland von 400 000 alkoholabhängigen Personen älter als 60 Jahre und über 2 Millionen mit riskantem Alkoholkonsum aus. Zum Verlauf der Suchterkrankung, aktuellen Konsummustern, psychischer und somatischer Komorbidität ist bei den älteren Suchtkranken wenig bekannt. Im Kontrast zu den hohen Zahlen von Betroffenen sind ältere Alkoholkranke in ambulanten wie stationären Suchthilfeeinrichtungen deutlich unterrepräsentiert. Im folgenden Artikel wird der aktuelle Stand zu Diagnostik und evidenzbasierter Therapie alkoholbezogener Störungen im Alter referiert. Dabei werden im psychotherapeutischen Teil die Methoden der Kurzintervention und der Kognitiven Verhaltenstherapie, im pharmakologischen Teil die Substanzen Disulfiram, Acamprosat und Naltrexon kritisch bewertet. Daraus abgeleitet werden erste Empfehlungen zum therapeutischen Vorgehen ausgesprochen.
Abstract
Due to demographic trends and an aging cohort, which has higher rates of substance abuse than any previous generation, an increase in numbers of elderly alcohol abusers is predicted. The number of older alcohol dependent adults in Germany has been estimated to 400 000, the prevalence of risky use up to 2 million. Despite this reported high prevalence, patients over age 60 are seldom seen attending in- or outpatient treatment programs for alcohol dependence. In addition, little is known about this growing population of older adults with alcohol-related disease, e. g. regarding course of alcohol addiction, consumption patterns, somatic and mental comorbid disorders. This article shows the state of research in this area and reviews clinically-relevant concepts related to identifying, assessing and treating older adults with alcohol-related disability. Emphasis will be placed on the psychotherapy-methods of brief interventions and cognitive-behavioral therapy and on the pharmacological approaches for treating alcohol dependence with disulfiram, acamprosate and naltrexone.
Schlüsselwörter
Alkoholabhängigkeit - Alter - Psychotherapie - KOALA - Pharmakotherapie
Key words
alcohol dependence - older adult - psychotherapy - KOALA - pharmacotherapy
Literatur
- 1 Lopez A D, Mathers C D, Ezzati M, Jamison D T, Murray C J. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet. 2006; 367 1747-1757
- 2 Beutel M, Baumann M. Rehabilitation suchtkranker älterer Patienten. Suchttherapie. 2000; 1 155-162
- 3 Drew L R. Alcoholism as a self-limiting disease. Q J Stud Alcohol. 1968; 29 956-967
- 4 Mundle G. Die Alkoholabhängigkeit im Alter. Sucht. 1997; 43 (3) 201-206
- 5 Beresford T P. Alcoholic elderly: prevalence, screening, diagnosis and prognosis. In: Beresford TP, Gomberg ESL (Hrsg). Alcohol and Aging. New York: Oxford University Press 1995: 3-18
- 6 Oslin D. Late-life alcoholism: issues relevant to the geriatric psychiatrist. Am J Geriatr Psychiatry. 2004; 12 571-583
- 7 Patterson T L, Jeste D V. The potential impact of the baby-boom generation on substance abuse among elderly persons. Psychiatr Serv. 1999; 50 1184-1188
- 8 Blow F C, Barry K L. Use and misuse of alcohol among older women. Alcohol Res Health. 2002; 26 308-315
- 9 Blow F C, Brockmann L M, Barry K L. Role of alcohol in late-life suicide. Alcohol Clin Exp Res. 2004; 28 48-56
- 10 Fink A, Hays R D, Moore A A, Beck J C. Alcohol-related problems in older persons. Determinants, consequences, and screening. Arch Intern Med. 1996; 156 1150-1156
- 11 Waern M, Spak F, Sundh V. Suicidal ideation in a female population sample. Relationship with depression, anxiety disorder and alcohol dependence/abuse. Eur Arch Psychiatry Clin Neurosci. 2002; 252 81-85
- 12 Babor T F, Hofmann M, DelBoca F K. et al . Types of alcoholics, I. Evidence for an empirically derived typology based on indicators of vulnerability and severity. Arch Gen Psychiatry. 1992; 49 599-608
- 13 Cloninger C R, Bohman M, Sigvardsson S. Inheritance of alcohol abuse. Cross-fostering analysis of adopted men. Arch Gen Psychiatry. 1981; 38 861-868
- 14 Lesch O M, Walter H. Subtypes of alcoholism and their role in therapy. Alcohol Alcohol Suppl. 1996; 1 63-67
- 15 Schuckit M A. Geriatric alcoholism and drug abuse. Gerontologist. 1977; 17 168-174
- 16 Droller H. Some Aspects of alcoholism in the elderly. Lancet. 1964; 18 137-139
- 17 Gomberg E SL, Hegedus A M, Zucker R A. Research issues and priorities. In: Gomberg ESL, Hegedus AM, Zucker RA (Hrsg). Alcohol problems and aging. Bethesda, MD: National Institutes of Health 1998: 451-475
- 18 Allen J. Alcoholism in the elderly. Council on Scientific Affairs, American Medical Association. JAMA. 1996; 275 797-801
- 19 Barrick C, Connors G J. Relapse prevention and maintaining abstinence in older adults with alcohol-use disorders. Drugs Aging. 2002; 19 583-594
- 20 Brennan P L, Moos R H. Functioning, life context, and help-seeking among late-onset problem drinkers: comparisons with nonproblem and early-onset problem drinkers. Br J Addict. 1991; 86 1139-1150
- 21 Hurt R D, Finlayson R E, Morse R M, Davis Jr L J. Alcoholism in elderly persons: medical aspects and prognosis of 216 inpatients. Mayo Clin Proc. 1988; 63 753-760
- 22 Brennan P L, Schutte K K, Moos R H. Reciprocal relations between stressors and drinking behavior: a three-wave panel study of late middle-aged and older women and men. Addiction. 1999; 94 737-749
- 23 Schutte K K, Brennan P L, Moos R H. Predicting the development of late-life late-onset drinking problems: a 7-year prospective study. Alcohol Clin Exp Res. 1998; 22 1349-1358
- 24 Wetterling T, Veltrup C, John U, Driessen M. Late onset alcoholism. Eur Psychiatry. 2003; 18 112-118
- 25 Dawson D A. The link between family history and early onset alcoholism: earlier initiation of drinking or more rapid development of dependence?. J Stud Alcohol. 2000; 61 637-646
- 26 Whitfield J B, Zhu G, Madden P A, Neale M C, Heath A C, Martin N G. The genetics of alcohol intake and of alcohol dependence. Alcohol Clin Exp Res. 2004; 28 1153-1160
- 27 Schonfeld L, Dupree L W. Antecedents of drinking for early- and late-onset elderly alcohol abusers. J Stud Alcohol. 1991; 52 587-592
- 28 Saitz R. Clinical practice. Unhealthy alcohol use. N Engl J Med. 2005; 352 596-607
- 29 Corrao G, Bagnardi V, Zambon A, Arico S. Exploring the dose-response relationship between alcohol consumption and the risk of several alcohol-related conditions: a meta-analysis. Addiction. 1999; 94 1551-1573
- 30 Edwards G, Arif A, Hadgson R. Nomenclature and classification of drug- and alcohol-related problems: a WHO Memorandum. Bull World Health Organ. 1981; 59 225-242
- 31 Dilling H, Mombour W, Schmidt M H. Kapitel V (F), klinisch-diagnostische Leitlinien. In: Weltgesundheitsorganisation, Internationale Klassifikation psychischer Störungen. Bern: Huber 1991
- 32 Sass H. Diagnostisches und Statistisches Manual Psychischer Störungen - Textrevision - DSM-IV-TR. Göttingen: Hogrefe 2003
- 33 Blow F C. Substance abuse among older americans. Treatment Improvement Protocol, Treatment CfSA. Washington, DC: U.S. Government Printing Office 1996
- 34 National Institute on Alcohol Abuse and Alcoholism . Diagnostic criteria for alcohol abuse. Alcohol Alert. 1995; 30 (PH 359) 1-6
- 35 Wittchen H J. SKID - I: Strukturiertes Klinisches Interview für DSM IV. Göttingen: Hogrefe 1997
- 36 Bühringer G, Augustin R, Bergmann E. et al .Alkoholkonsum und alkoholbezogene Störungen in Deutschland. Schriftenreihe des Bundesministeriums für Gesundheit. Baden-Baden: Nomos 2000
- 37 Mann K F. Neue ärztliche Aufgaben bei Alkoholproblemen. Deutsches Ärzteblatt. 2002; 10 A632-A644
- 38 Kraus L, Bauernfeind R. Repräsentativerhebung zum Konsum psychotroper Substanzen bei Erwachsenen in Deutschland 1997. Sucht. 1998; 44 (Sonderheft 1) 1-84
- 39 Meyer C, Rumpf H J, Hapke U, Dilling H, John U. Prevalence of alcohol consumption, abuse and dependence in a country with high per capita consumption: findings from the German TACOS study. Transitions in alcohol consumption and smoking. Soc Psychiatry Psychiatr Epidemiol. 2000; 35 539-547
- 40 Adams W L, Barry K L, Fleming M F. Screening for problem drinking in older primary care patients. JAMA. 1996; 276 1964-1967
- 41 Gurland B J, Cross P S. Epidemiology of psychopathology in old age. Some implications for clinical services. Psychiatr Clin North Am. 1982; 5 11-26
- 42 Robins L N, Helzer J E, Weissman M M. et al . Lifetime prevalence of specific psychiatric disorders in three sites. Arch Gen Psychiatry. 1984; 41 949-958
- 43 Allebeck P. Risks and Protective Effects of Alcohol on the Individual. Proceedings of a conference. Alcohol Clin Exp Res. 1998; 22 269-373
- 44 Helmchen H, Linden M, Wernicke T. Psychiatrische Morbidität bei Hochbetagten. Ergebnisse aus der Berliner Altersstudie. Nervenarzt. 1996; 67 739-750
- 45 Weyerer S, Schaufele M, Zimber A. Alcohol problems among residents in old age homes in the city of Mannheim, Germany. Aust N Z J Psychiatry. 1999; 33 825-830
- 46 Weyerer S. Missbrauch und Abhängigkeit von Alkohol und Benzodiazepinen im höheren Alter. Basel: Suchtmagazin 2003: 3-9
- 47 Sonntag D, Welsch K, Bauer C. Deutsche Suchthilfestatistik 2004 für stationäre Einrichtungen. Sucht. 2005; 51 Sonderheft 2 39-64
- 48 Sonntag D, Bauer C, Welsch K. Deutsche Suchthilfestatistik 2004 für ambulante Einrichtungen. Sucht. 2005; 51 Sonderheft 2 6-38
- 49 Statistisches Bundesamt .Mikrozensus. www.destatis.de 2004
- 50 Rumpf H J, Weyerer S. Suchterkrankungen im Alter. In: Deutsche Hauptstelle für Suchtfragen e. V.- DHS, Jahrbuch Sucht 2006. Geesthacht: Neuland 2006: 189-199
- 51 Berner M M, Zeidler C, Kriston L, Mundle G, Lorenz G, Harter M. Diagnostik und Behandlung alkoholbezogener Störungen. Fortschr Neurol Psychiatr. 2006; 74 157-164
- 52 Atkinson R M. Aging and alcohol use disorders: diagnostic issues in the elderly. Int Psychogeriatr. 1990; 2 55-72
- 53 Geller G, Levine D M, Mamon J A, Moore R D, Bone L R, Stokes E J. Knowledge, attitudes, and reported practices of medical students and house staff regarding the diagnosis and treatment of alcoholism. JAMA. 1989; 261 3115-3120
- 54 Kaner E F, Wutzke S, Saunders J B, Powell A, Morawski J, Bouix J C. Impact of alcohol education and training on general practitioners' diagnostic and management skills: findings from a World Health Organization collaborative study. J Stud Alcohol. 2001; 62 621-627
- 55 Mann K F, Kapp B. Zur Lehre in Suchtmedizin - eine Befragung von Studenten und Professoren. In: Mann KF, Buchkremer G (Hrsg). Suchtforschung und Suchttherapie in Deutschland. Sonderheft der Zeitschrift Sucht. Hamm: Neuland 1995: 38-40
- 56 Barry K L, Oslin D W, Blow F C. Prevention and management of alcohol problems in older adults. New York: Springer Publishing 2001
- 57 Aertgeerts B, Buntinx F, Ansoms S, Fevery J. Screening properties of questionnaires and laboratory tests for the detection of alcohol abuse or dependence in a general practice population. Br J Gen Pract. 2001; 51 206-217
- 58 Salaspuro M. Carbohydrate-deficient transferrin as compared to other markers of alcoholism: a systematic review. Alcohol. 1999; 19 261-271
- 59 Hock B, Schwarz M, Domke I. et al . Validity of carbohydrate-deficient transferrin (%CDT), gamma-glutamyltransferase (γ-GT) and mean corpuscular erythrocyte volume (MCV) as biomarkers for chronic alcohol abuse: a study in patients with alcohol dependence and liver disorders of non-alcoholic and alcoholic origin. Addiction. 2005; 100 1477-1486
- 60 Beresford T P, Blow F C, Hill E, Singer K, Lucey M R. Comparison of CAGE questionnaire and computer-assisted laboratory profiles in screening for covert alcoholism. Lancet. 1990; 336 482-485
- 61 Hays R D, Revetto J P. Old and new MMPI-derived scales and the short-MAST as screening tools for alcohol disorder. Alcohol Alcohol. 1992; 27 685-695
- 62 Rumpf H J. Epidemiologie des Alkoholmißbrauchs im höheren Alter. In: Havemann-Reinicke U, Weyerer S, Fleischmann H (Hrsg). Alkohol und Medikamente, Missbrauch und Abhängigkeit im Alter. Freiburg im Breisgau: Lambertus 1998: 29-37
- 63 Rist F, Demmel R, Hapke G, Kremer G, Rumpf H J. Alkoholbezogene Störungen: Screening und Kurzintervention. In: Schmidt LG, Gastpar M, Falkai P, Gaebel W (Hrsg). Evidenzbasierte Suchtmedizin. Köln: Deutscher Ärzte-Verlag 2006: 11-24
- 64 Saunders J B, Aasland O G, Babor T F, de la Fuente J R, Grant M. Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption-II. Addiction. 1993; 88 791-804
- 65 Mayfield D, McLeod G, Hall P. The CAGE questionnaire: validation of a new alcoholism screening instrument. Am J Psychiatry. 1974; 131 1121-1123
- 66 Buchsbaum D G, Buchanan R G, Welsh J, Centor R M, Schnoll S H. Screening for drinking disorders in the elderly using the CAGE questionnaire. J Am Geriatr Soc. 1992; 40 662-665
- 67 Moore A A, Beck J C, Babor T F, Hays R D, Reuben D B. Beyond alcoholism: identifying older, at-risk drinkers in primary care. J Stud Alcohol. 2002; 63 316-324
- 68 Selzer M L. The Michigan alcoholism screening test: the quest for a new diagnostic instrument. Am J Psychiatry. 1971; 127 1653-1658
- 69 Selzer M L, Vinokur A, Rooijen R L van. A self-administered Short Michigan Alcoholism Screening Test (SMAST). J Stud Alcohol. 1975; 36 117-126
- 70 Blow F C, Gillespie B W, Barry K L. Brief screening for alcohol problems in elderly populations using the Short Michigan Alcoholism Screening Test-Geriatric Version (SMAST-G). Alcoholism Clin Exp Res. 1998; 22 (Suppl) 20-25
- 71 Moore A A, Seeman T, Morgenstern H, Beck J C, Reuben D B. Are there differences between older persons who screen positive on the CAGE questionnaire and the Short Michigan Alcoholism Screening Test-Geriatric Version?. J Am Geriatr Soc. 2002; 50 858-862
- 72 Rumpf H J, Hapke U, John U. Deutsche Version des CAGE Fragebogens (Cage-G). In: Glöckner-Rist A, Rist F, Küfner H (Hrsg). Elektronisches Handbuch zu Erhebungsinstrumenten im Suchtbereich (EHES) - Version 3.00. Mannheim: Zentrum für Umfragen, Methoden und Analysen 2003
- 73 Deutsche Hauptstelle für Suchtfragen e. V. - DHS .Alkohol - Alkoholprobleme erkennen und ansprechen. Substanzbezogene Störungen im Alter. Hamm: DHS 2005: 30-34
- 74 Atkinson R M. Treatment programs for aging alcoholics. In: Beresford TP, Gomberg ESL (Hrsg). Alcohol and aging. New York: Oxford University Press 1995
- 75 Kashner T M, Rodell D E, Ogden S R, Guggenheim F G, Karson C N. Outcomes and costs of two VA inpatient treatment programs for older alcoholic patients. Hosp Community Psychiatry. 1992; 43 985-989
- 76 Kofoed L L, Tolson R L, Atkinson R M, Toth R L, Turner J A. Treatment compliance of older alcoholics: an elder-specific approach is superior to “mainstreaming”. J Stud Alcohol. 1987; 48 47-51
- 77 Lemke S, Moos R H. Outcomes at 1 and 5 years for older patients with alcohol use disorders. J Subst Abuse Treat. 2003; 24 43-50
- 78 Lemke S, Moos R H. Treatment and outcomes of older patients with alcohol use disorders in community residential programs. J Stud Alcohol. 2003; 64 219-226
- 79 Brennan P L, Moos R H. Late-life drinking behavior: The influence of personal characteristics, life context, and treatment. Alcohol Health Research World. 1996; 20 197-204
- 80 Liberto J G, Oslin D W. Early versus late onset of alcoholism in the elderly. Int J Addict. 1995; 30 1799-1818
- 81 Donovan D M, Marlatt G A. Recent developments in alcoholism: behavioral treatment. Recent DRev Alcohol. 1993; 11 397-411
- 82 Heather N. Interpreting the evidence on brief interventions for excessive drinkers: the need for caution. Alcohol Alcohol. 1995; 30 287-296
- 83 Heather N. The public health and brief interventions for excessive alcohol consumption: the British experience. Addict Behav. 1996; 21 857-868
- 84 Babor T F. Avoiding the horrid and beastly sin of drunkenness: does dissuasion make a difference?. J Consult Clin Psychol. 1994; 62 1127-1140
- 85 Miller W R, Sanchez V C. Motivating young adults for treatment and lifestyle change. In: Howard GS, Nathan PE (Hrsg). Alcohol use and misuse by young adults. Notre Dame, IN: University of Notre Dame Press 1994: 55-82
- 86 Beich A, Thorsen T, Rollnick S. Screening in brief intervention trials targeting excessive drinkers in general practice: systematic review and meta-analysis. BMJ. 2003; 327 536-542
- 87 Moyer A, Finney J W, Swearingen C E, Vergun P. Brief interventions for alcohol problems: a meta-analytic review of controlled investigations in treatment-seeking and non-treatment-seeking populations. Addiction. 2002; 97 279-292
- 88 Whitlock E P, Polen M R, Green C A, Orleans T, Klein J. Behavioral counseling interventions in primary care to reduce risky/harmful alcohol use by adults: a summary of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med. 2004; 140 557-568
- 89 Fleming M F, Manwell L B, Barry K L, Adams W, Stauffacher E A. Brief physician advice for alcohol problems in older adults: a randomized community-based trial. J Fam Pract. 1999; 48 378-384
- 90 American Psychiatric Association . Practice guideline for the treatment of patients with substance use disorders: alcohol, cocaine, opioids. 5. Am J Psychiatry. 1995; 152 1-59
- 91 Allen J. Matching Alcoholism Treatments to Client Heterogeneity: Project MATCH posttreatment drinking outcomes. J Stud Alcohol. 1997; 58 7-29
- 92 Allen J. Project MATCH secondary a priori hypotheses. Project MATCH Research Group. Addiction. 1997; 92 1671-1698
- 93 Andréasson S, Öjehagen A. Psychosocial treatment for alcohol dependence. In: Berglund M, Thelander S, Jonsson E (Hrsg). Treating Alcohol and drug abuse. An evidence based review. Weinheim: Wiley-VCH 2003: 43-188
- 94 Babor T F, DelBoca F K. Treatment matching in alcoholism. Cambridge: University Press 2003
- 95 Graham K, Annis H M, Brett P J, Venesoen P. A controlled field trial of group versus individual cognitive-behavioural training for relapse prevention. Addiction. 1996; 91 1127-1139
- 96 Morgenstern J, Longabaugh R. Cognitive-behavioral treatment for alcohol dependence: a review of evidence for its hypothesized mechanisms of action. Addiction. 2000; 95 1475-1490
- 97 Rist F. Evidenzbasierte Psychotherapie Alkoholabhängiger: Der Beitrag kognitiv-verhaltenstherapeutischer Verfahren. Sucht. 2002; 48 171-181
- 98 Geyer D, Beutel M, Funke W. et al .Alkoholbezogene Störungen: Postakutbehandlung. In: Schmidt LG, Gastpar M, Falkai P, Gaebel W (Hrsg). Evidenzbasierte Suchtmedizin. Köln: Deutscher Ärzte-Verlag 2006: 52-89
- 99 Beck A T, Wright F D, Newman C F, Liese B S. Cognitive therapy of substance abuse. New York: Guilford Press 1993
- 100 Marlatt G A, Gordon J R. Relapse prevention. New York: Guilford Press 1985
- 101 Monti P M, Abrams D B, Binkoff J A. et al . Communication skills training, communication skills training with family and cognitive behavioral mood management training for alcoholics. J Stud Alcohol. 1990; 51 263-270
- 102 Schuckit M A, Pastor Jr P A. The elderly as a unique population: alcoholism. Alcohol Clin Exp Res. 1978; 2 31-38
- 103 Wiens A N, Menustik C E, Miller S I, Schmitz R E. Medical-behavioral treatment of the older alcoholic patient. Am J Drug Alcohol Abuse. 1982; 9 461-475
- 104 Williams S H. Medications for treating alcohol dependence. Am Fam Physician. 2005; 72 1775-1780
- 105 Oslin D, Liberto J G, O'Brien J, Krois S, Norbeck J. Naltrexone as an adjunctive treatment for older patients with alcohol dependence. Am J Geriatr Psychiatry. 1997; 5 324-332
- 106 Hald E, Jacobson I. A drug sensitising the organism to ethylalcohol. Lancet. 1948; ii 1001-1003
- 107 Platz W E. Suchttherapeutika, Alkoholentwöhnungsmittel, Disulfiram. In: Riederer P, Laux G (Hrsg). Neuropsychopharmaka Band 6. Wien: Springer 2005: 398-409
- 108 West S L, Garbutt J C, Carey T S, Lux L J, Jackman A M, Tolleson-Rinehart S. Pharmokotherapy for alcohol dependence. Rockville: Md.: U.S. Department of Health and Human Services; Public Health Service; Agency for Health Care Policy and Research 1999
- 109 Garbutt J C, West S L, Carey T S, Lohr K N, Crews F T. Pharmacological treatment of alcohol dependence: a review of the evidence. JAMA. 1999; 281 1318-1325
- 110 Azrin N H, Sisson R W, Meyers R, Godley M. Alcoholism treatment by disulfiram and community reinforcement therapy. J Behav Ther Exp Psychiatry. 1982; 13 105-112
- 111 Chick J, Gough K, Falkowski W. et al . Disulfiram treatment of alcoholism. Br J Psychiatry. 1992; 161 84-89
- 112 Lhuintre J P, Daoust M, Moore N D. et al . Ability of calcium bis acetyl homotaurine, a GABA agonist, to prevent relapse in weaned alcoholics. Lancet. 1985; 1 1014-1016
- 113 Lhuintre J P, Moore N, Tran G. et al . Acamprosate appears to decrease alcohol intake in weaned alcoholics. Alcohol Alcohol. 1990; 25 613-622
- 114 al Qatari M, Bouchenafa O, Littleton J. Mechanism of action of acamprosate. Part II. Ethanol dependence modifies effects of acamprosate on NMDA receptor binding in membranes from rat cerebral cortex. Alcohol Clin Exp Res. 1998; 22 810-814
- 115 Littleton J, Zieglgansberger W. Pharmacological mechanisms of naltrexone and acamprosate in the prevention of relapse in alcohol dependence. Am J Addict. 2003; 12 Suppl 1 3-11
- 116 Rammes G, Mahal B, Putzke J. et al . The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801. Neuropharmacology. 2001; 40 749-760
- 117 Soyka M. Suchttherapeutika, Alkoholentwöhnungsmittel, Acamprosat. In: Riederer P, Laux G (Hrsg). Neuropsychopharmaka Band 6. Wien: Springer 2005: 387-392
- 118 Besson J, Aeby F, Kasas A, Lehert P, Potgieter A. Combined efficacy of acamprosate and disulfiram in the treatment of alcoholism: a controlled study. Alcohol Clin Exp Res. 1998; 22 573-579
- 119 Chick J, Howlett H, Morgan M Y, Ritson B. United Kingdom Multicentre Acamprosate Study (UKMAS): a 6-month prospective study of acamprosate versus placebo in preventing relapse after withdrawal from alcohol. Alcohol Alcohol. 2000; 35 176-187
- 120 Gual A, Lehert P. Acamprosate during and after acute alcohol withdrawal: a double-blind placebo-controlled study in Spain. Alcohol Alcohol. 2001; 36 413-418
- 121 Kiefer F, Jahn H, Tarnaske T. et al . Comparing and combining naltrexone and acamprosate in relapse prevention of alcoholism: a double-blind, placebo-controlled study. Arch Gen Psychiatry. 2003; 60 92-99
- 122 Ladewig D, Knecht T, Leher P, Fendl A. Acamprosat - ein Stabilisierungsfaktor in der Langzeitentwöhnung von Alkoholabhängigen. Ther Umsch. 1993; 50 182-188
- 123 Namkoong K, Lee B O, Lee P G, Choi M J, Lee E. Acamprosate in Korean alcohol-dependent patients: a multi-centre, randomized, double-blind, placebo-controlled study. Alcohol Alcohol. 2003; 38 135-141
- 124 Paille F M, Guelfi J D, Perkins A C, Royer R J, Steru L, Parot P. Double-blind randomized multicentre trial of acamprosate in maintaining abstinence from alcohol. Alcohol Alcohol. 1995; 30 239-247
- 125 Pelc I, Le B O, Verbanck P. Calcium acetyl homotaurinate for maintaining abstinence in weaned alcoholic patients; a placebo-controlled double-blind multi-centre study. In: Naranjo C, Sellers E (Hrsg). Novel pharmacological interventions for alcoholism. New York: Springer 1992: 348-352
- 126 Pelc I, Verbanck P, Le B O, Gavrilovic M, Lion K, Lehert P. Efficacy and safety of acamprosate in the treatment of detoxified alcohol-dependent patients. A 90-day placebo-controlled dose-finding study. Br J Psychiatry. 1997; 171 73-77
- 127 Poldrugo F. Acamprosate treatment in a long-term community-based alcohol rehabilitation programme. Addiction. 1997; 92 1537-1546
- 128 Roussaux J P, Hers D, Ferauge M. Does acamprosate diminish the appetite for alcohol in weaned alcoholics?. J Pharm Belg. 1996; 51 65-68
- 129 Sass H, Soyka M, Mann K, Zieglgansberger W. Relapse prevention by acamprosate. Results from a placebo-controlled study on alcohol dependence. Arch Gen Psychiatry. 1996; 53 673-680
- 130 Tempesta E, Janiri L, Bignamini A, Chabac S, Potgieter A. Acamprosate and relapse prevention in the treatment of alcohol dependence: a placebo-controlled study. Alcohol Alcohol. 2000; 35 202-209
- 131 Whitworth A B, Fischer F, Lesch O M. et al . Comparison of acamprosate and placebo in long-term treatment of alcohol dependence. Lancet. 1996; 347 1438-1442
- 132 Mann K F, Lehert P, Morgan M Y. The efficacy of acamprosate in the maintenance of abstinence in alcohol-dependent individuals: results of a meta-analysis. Alcohol Clin Exp Res. 2004; 28 51-63
- 133 Gillan M G, Kosterlitz H W, Paterson S J. Comparison of the binding characteristics of tritiated opiates and opioid peptides. Br J Pharmacol. 1980; 70 481-490
- 134 Magnan J, Paterson S J, Tavani A, Kosterlitz H W. The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties. Naunyn Schmiedebergs Arch Pharmacol. 1982; 319 197-205
- 135 Altshuler H L, Phillips P E, Feinhandler D A. Alteration of ethanol self-administration by naltrexone. Life Sci. 1980; 26 679-688
- 136 Pettinati H M, O'Brien C P, Rabinowitz A R. et al . The status of naltrexone in the treatment of alcohol dependence: specific effects on heavy drinking. J Clin Psychopharmacol. 2006; 26 610-625
- 137 Mann K F. Suchttherapeutika, Alkoholentwöhnungsmittel, Naltrexon. In: Riederer P, Laux G (Hrsg). Neuropsychopharmaka Band 6. Wien: Springer 2005: 392-398
- 138 Lieb B, Rosien M. KOALA - Kognitive Verhaltenstherapie der Alkoholabhängigkeit im Alter, ein Therapiemanual in 12 Sitzungen. Essen: unveröffentlicht 2007
Dr. Bodo Lieb
Klinik für abhängiges Verhalten und Suchtmedizin der Universität Duisburg-Essen, Rheinische Kliniken Essen
Virchowstr. 174
45147 Essen