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Synfacts 2008(2): 0217-0217
DOI: 10.1055/s-2007-992512
DOI: 10.1055/s-2007-992512
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York
Tagged Hypervalent Iodine Reagents
E. Kunst, F. Gallier, G. Dujardin, M. S. Yusubov, A. Kirschning*
Leibniz University Hannover, Germany; Université du Maine, Le Mans, France; The Siberian State Medical University and The Tomsk Polytechnic University, Tomsk, Russia
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. Januar 2008 (online)
![](https://www.thieme-connect.de/media/synfacts/200802/lookinside/thumbnails/10.1055-s-2007-992512-1.jpg)
Significance
Aryl iodine(III) reagents bearing a sulfonate tag were prepared and used in the ruthenium-catalyzed alcohol oxidation as oxidant. Thus, the oxidations of various alcohols were carried out with 0.5 mol% of RuCl3 and 1.5-3.2 equiv of the tagged iodine(III) reagent in aqueous acetonitrile at r.t. to give the corresponding ketones (or carboxylic acids) in high yield. The reaction mixture was treated with polymeric ammonium azide (ion-exchange resin) at 100 °C under microwave conditions to scavenge the unreacted iodine(III) and reacted iodine(I) during which the co-produced isobutylazide was evaporated affording the desired products.