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Synfacts 2008(2): 0161-0161  
DOI: 10.1055/s-2007-992482
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Novel N,N′-Dioxide-Copper(I) Catalyst for Enantioselective Henry Reactions

Contributor(s): Mark Lautens, Valentina Aureggi
B. Quin, X. Xiao, X. Liu, J. Huang, Y. Wen, X. Feng*
Sichuan University, Chengdu, P. R. of China
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Publication History

Publication Date:
23 January 2008 (online)

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Significance

The development of a new chiral N,N′-dioxide-copper(I) catalyst for efficient enan­tioselective Henry reactions is reported. The corresponding nitroalcohol products, from aldehydes and α-keto esters, are obtained in good yields and high enantioselectivities. In Henry reactions only a few catalytic systems are efficient for both aldehydes and α-keto esters. The method is versatile and tolerant towards air and moisture.