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Synfacts 2007(12): 1252-1252
DOI: 10.1055/s-2007-991405
DOI: 10.1055/s-2007-991405
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York
AlCl3-Mediated Synthesis of Furans from Acid Chlorides and bis-Silylated Butadiene
F. Babudri, S. R. Cicco, G. M. Farinola, L. C. Lopez, F. Naso*, V. Pinto
Università degli Studi di Bari, Italy
Further Information
Publication History
Publication Date:
22 November 2007 (online)
![](https://www.thieme-connect.de/media/synfacts/200712/lookinside/thumbnails/10.1055-s-2007-991405-1.jpg)
Significance
Reported is a synthesis of di- or tri-substituted furans via condensation-cyclization reactions from readily available bis-silylated diene 1 and acyl chlorides in the presence of AlCl3. The resulting 2,3,5-trisubstituted furans 2 easily undergo desilylation under acidic workup conditions or by the treatment of BF3 etherate to afford 2,5-disubstituted furans 3. The scope of the reaction with respect to the acyl chlorides was not well investigated.