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Synfacts 2007(12): 1271-1271
DOI: 10.1055/s-2007-991375
DOI: 10.1055/s-2007-991375
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Iron-Catalyzed Epoxidations with Hydrogen Peroxide
F. G. Gelalcha, B. Bitterlich, G. Anilkumar, M. K. Tse, M. Beller*
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Germany
Further Information
Publication History
Publication Date:
22 November 2007 (online)
Significance
Asymmetric epoxidations give enantioenriched oxiranes which are versatile intermediates in fine chemical synthesis. Currently, most methods involve either atom-inefficient oxidants or the use of expensive transition metals. The authors report an iron catalyst/hydrogen peroxide based method to access chiral oxiranes in high yields and moderate to high enantioselectivities.