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Synfacts 2007(12): 1281-1281
DOI: 10.1055/s-2007-991372
DOI: 10.1055/s-2007-991372
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Mechanistic Insight into Iridium-Catalyzed Asymmetric Allylations
D. Markovič , J. F. Hartwig*
University of Illinois, Urbana and Yale University, New Haven, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. November 2007 (online)
![](https://www.thieme-connect.de/media/synfacts/200712/lookinside/thumbnails/10.1055-s-2007-991372-1.jpg)
Significance
The authors report the first kinetic data on iridium-catalyzed asymmetric allylic substitutions, giving helpful mechanistic insight into this reaction. Upon mixing aniline with cinnamyl carbonate, complex A was isolated and, thus, believed to lie within the catalytic cycle. The reaction catalyzed by A had the same branched-to-linear ratio and enantioselectivity as that from the traditional combination of [Ir(cod)Cl]2 and phosphoramidite ligand.