RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
Synfacts 2007(12): 1292-1292
DOI: 10.1055/s-2007-991370
DOI: 10.1055/s-2007-991370
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
New Ligands for Rhodium-Catalyzed Asymmetric Hydrogenation of Olefins
L. Eberhardt, D. Armspach*, D. Matt*, B. Oswald, L. Toupet
Université des Rennes, Institut de Chimie and Université Louis Pasteur, Strasbourg, France and Genzyme Pharmaceuticals, Liestal, Switzerland
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. November 2007 (online)
![](https://www.thieme-connect.de/media/synfacts/200712/lookinside/thumbnails/10.1055-s-2007-991370-1.jpg)
Significance
The present work illustrates that enantiopure BINOL-derived diphosphoramidite ligands with hydrazine spacers are good ligands for the rhodium-catalyzed hydrogenation of 2-acetylamino-3-arylpropenoic methyl esters. The substituents on the two hydrazine nitrogens have a large influence on the enantioselectivity of the reaction, with bulky symmetrical groups leading to the highest ee values.