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Synfacts 2007(12): 1256-1256  
DOI: 10.1055/s-2007-991357
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart · New York

A Dynamic Covalent Approach

Contributor(s): Timothy M. Swager, Gaku Fukuhara
C. S. Hartley, J. S. Moore*
University of Illinois at Urbana-Champaign, USA
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Publikationsdatum:
22. November 2007 (online)

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Significance

The authors demonstrated the first sequence-directed, dynamic covalent approach to unsymmetrical macrocycles like A 6 , (AB) 3 , A 5 B, A 4 B 2 , and A 3 B 3 using imine formation and exchange. Formation of macrocycle A 6 was carried out by treating 1 AA with Sc(OTf)3 in 1,2,4-trichlorobenzene at 75 ºC for 3 hours, followed by stirring under reduced pressure (1 mmHg) at room temperature for 5 hours. By combining corresponding monomer(s), (AB) 3 , A 5 B, A 4 B 2 , and A 3 B 3 were also obtained in similar manner.