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Synfacts 2007(12): 1298-1298
DOI: 10.1055/s-2007-991321
DOI: 10.1055/s-2007-991321
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Copper-Catalyzed Sulfonylation of Arylboronic Acids
A. Kar, I. A. Sayyed, W. F. Lo, H. M. Kaiser, M. Beller, M. K. Tse*
Leibniz-Institut für Katalyse e.V. and der Universität rostock and Universität Rostock, Germany
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. November 2007 (online)
Significance
Aryl sulfones are widely present among modern drugs and various biologically active compounds. Herein, the authors report a catalytic version of Cu-promoted sulfonylation of boronic acids with alkyl- and arylsulfinate salts. This method tolerates most functional groups, including free hydroxyl, and can be applied as well to heterocycles and alkenylboronic acids. The broad range of suitable substrates makes this protocol especially attractive for modular and combinatorial synthesis.