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Synfacts 2007(12): 1300-1300
DOI: 10.1055/s-2007-991319
DOI: 10.1055/s-2007-991319
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Reductive Perfluoroalkylation of Esters with Perfluoroalkyl Titanates
K. Mikami*, T. Murase, Y. Itoh
Tokyo Institute of Technology, Japan
Further Information
Publication History
Publication Date:
22 November 2007 (online)
![](https://www.thieme-connect.de/media/synfacts/200712/lookinside/thumbnails/10.1055-s-2007-991319-1.jpg)
Significance
This method represents an easy way for the preparation of secondary alcohols, bearing a perfluorinated chain. The reaction of a perfluoroalkylmagnesium species with Ti(Oi-Pr)4 gives an at room temperature remarkably stable perfluoroalkylmetallic reagent, which easily reacts with aldehydes and esters. In both cases, the product is a perfluorinated secondary alcohol. The discovery of a stable perfluoroalkyl metal species should lead to other useful synthetic methods in this interesting field of organic synthesis.