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Synfacts 2007(12): 1237-1237  
DOI: 10.1055/s-2007-991308
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Methyl Sarcophytoate

Contributor(s): Philip Kocienski
T. Ichige, Y. Okano, N. Kanoh, M. Nakata*
Keio University, Yokohama, Japan
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Publication History

Publication Date:
22 November 2007 (online)

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Significance

The synthesis of methyl sarco­phytoate depicted features a Diels-Alder reaction between two cembranoid units (H and I) - the probable biogenetic route to the natural product. A major achievement was the discovery of conditions for the macrocyclization reaction (E→F).