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Synfacts 2007(11): 1216-1216
DOI: 10.1055/s-2007-991218
DOI: 10.1055/s-2007-991218
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York
Sulfate Zirconia for Mannich Reaction
S. Wang, S. Matsumura, K. Toshima*
Keio University, Yokohama, Japan
Further Information
Publication History
Publication Date:
23 October 2007 (online)
![](https://www.thieme-connect.de/media/synfacts/200711/lookinside/thumbnails/10.1055-s-2007-991218-1.jpg)
Significance
The Mannich-type reaction of aldimines with ketene silyl acetals was promoted by sulfated zirconia SO4/ZrO2 as a solid acid. Thus, the reaction of 1 with 2 was carried out with SO4/ZrO2 in MeCN to give β-amino esters 3 in 65-100% yield (eq. 1). The catalyst was recovered and reused with a slight loss of catalytic activity (yield of 3; 1st use of SO4/ZrO2: 99%, 2nd use: 99%, 3rd use: 97%, 4th use 90%).