Synthesis 2007(22): 3542-3552  
DOI: 10.1055/s-2007-990861
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of 3-Trifluoromethyl- and 3-Perfluoroalkyl-Substituted 3-Aryloxy- and 3-Heteroaryloxypropenoic Acids and of the Cyclization Products, 2-Trifluoromethyl- and 2-Perfluoroalkyl-4H-chromen-4-ones

Salem El Kharrat, Rouba El Kharrat, Philippe Laurent*, Hubert Blancou
UMR-CNRS 5247 Matériaux Fluorés Synthèses et Applications, Université Montpellier, 2 c.c.1706, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France
Fax: +33(4)67631046; e-Mail: philippe.laurent@univ-montp2.fr;
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Publikationsverlauf

Received 4 June 2007
Publikationsdatum:
29. Oktober 2007 (online)

Abstract

We describe a novel and simple method for the regio­specific synthesis of functionalized trifluoromethyl- and perfluoroalkyl-containing 4H-chromen-4-ones via the cyclization of substituted 3-aryloxy-3-perfluoroalkylpropenoic acids. The procedures give the final products in high yields, without any need for chromatographic purification, and no side products.