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DOI: 10.1055/s-2007-990264
© Georg Thieme Verlag KG Stuttgart · New York
Discovery of the Apoptosis-Inducing Activity and High Accumulation of the Butenolides, Menisdaurilide and Aquilegiolide, in Dicentra spectabilis
Publication History
Received: May 10, 2007
Revised: September 7, 2007
Accepted: October 8, 2007
Publication Date:
19 December 2007 (online)
![](https://www.thieme-connect.de/media/plantamedica/200715/lookinside/thumbnails/10.1055-s-2007-990264-1.jpg)
Abstract
The occurrence of two butenolides, menisdaurilide and aquilegiolide, in commercial specimens of Dicentra spectabilis is reported for the first time; a rapid and direct isolation protocol is described. The ability of these lactones to induce apoptosis in human tumour cell lines at 10 μM concentration is also described. The high abundance and apoptosis-inducing activity reported here indicates that these constituents play a more significant role than the hormonal action previously attributed to them.
Key words
Lactones - apoptosis - Dicentra - Papaveraceae
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Prof. Dr. Jim McNulty
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