Endometrial thickness related to the cytologic and histopathologic diagnosis of endometrial lesions and cancer

Aims: The purpose of this study was to be included pre-postmenopausal women with abnormal bleeding to examined by TVS measurement of endometrial thickness and diagnosis of endometrial cytology and pathology by means of Endometrial sampling, Dilation and Curettage, Total Abdomen Hysterectomy.

Methods: Endogyn endometrial cell sampler from 357 pre-postmenopausal women with abnormal bleeding, 91D&Cs and 73 TAH. All the women examined by TVS and done measurement of endometrial thickness.

Results: No Cancer: Cytology 60%, histology 54%, D&C 57%,TAH 52%. Atrophic: Cytology 16%, histology12%,D&C 8%,TAH 17%. Hyperplasia without atypia: Cytology 8%, histology 10%, D&C 9%, TAH 10%. Hyperplasia or polyps: Cytology 3%. Endometrial polyps: Cytology 2%,histology 11%,D&C 13%,TAH 9%.Atypical hyperplasia: Cytology 2%, histology 3%, D&C 2%, TAH 3%. Cancer: Cytology 4%, histology 7%,D&C 5% TAH 9%. Unusable material 3%. Inadequate material: Cytology1, histology 1%, D&C 6%. Miscarriage sampling material: Cytology 2%. TVS results: The mean endometrial thickness for women with PMB with an istopathologic diagnosis atrophy was 3,5mm and normal endometrium in women with PMB of 4mm. No endometrial cancer below an endometrial measurement of 5mm. Endometrial cancer >6mm with range 6–30mm. It has been claimed that endometrial cavity fluid is correlated with a high risk of endometrial pathology.

Conclusion: However inadequate material of endometrial sampling and of D&C is one reason for the inaccuracy in diagnostic endometrial pathology.