Planta Med 2007; 73 - P_436
DOI: 10.1055/s-2007-987216

Anti-cancer agents from Formosan plants

YC Wu 1, FR Chang 1, CC Liaw 1, AS Lin 1, CC Wu 1
  • 1Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan

Cancer is the leading cause of death in Taiwan for years. In the current investigation, a herbal extract, WYC-01, from popular fruits, Annona squamosa and Annona muricata, and a pure compound, WYC-02 (protoapigenone) [1, 2, 3], from the Formosan pteridophyte, Thelypteris torresiana, were found to be potent promising candidates. The standardization and activity of WYC-01 was evaluated [4]. The major active components, squamocin and annonacin, were defined by HPLC technology. In addition, the total synthesis and cytotoxicity of WYC-02 and its analogues have been accomplished as well as their mechanism of actions and animal test in the ability of anti- breast cancer had also been evaluated.

WYC-02

Acknowledgements: 1. The Office of National Science and Technology Program for Biotechnology and Pharmaceuticals, Taiwan. 2. National Science Council, Taiwan

References: [1] Lin A. S. et al. (2005) Planta Med. 71: 867–870. [2] Lin A. S. et al. (2007) Chem. Pharm. Bull. 55: 635–637. [3] Lin A. S. et al. (2007) J. Med. Chem. Accepted for publication. [4] Wu, Y. C. US patent, USP 7,223,792.