New compounds from Fadogia agrestis (Rubiaceae)

Fadogia agrestis Schweinf. ex Hiern (Rubiaceae) is a shrub found from Guinea to Sudan. In African traditional medicine the decoction of this plant is extensively used as a febrifuge which could be associated with its use as an antimalarial drug. This shrub is also used as a diuretic and in the treatment of kidney pain and convulsions [1].

We report on the isolation and structure elucidation of two new monoterpene glycosides isolated from leaves of F. agrestis. These compounds have been isolated and identified by chromatographic and spectroscopic techniques [2–5] as:

Acknowledgements: Proyecto FISS(Rf:PI060119) & Ayudas a la Creación y Consolidación de Grupos de Investigación CAM-UAH(Rf:CG06-

UAH/SAL-0672)

References: [1] Adjanohoun, E.J. et al. (1989) Contribution aux études ethnobotaniques et floristiques en République populaire du Bénin. Médecine traditonnelle et pharmacopée 458–461. [2] Bock, K. et al. (1983) Adv. Carbohydr. Chem. Biochem. 41: 27–66. [3] Bock, K. et al. (1974) J. Chem. Soc., Perkin Trans. II, 293–297. [4] Iwagawa, T. et al. (1990) Phytochemistry 29: 1913–1916. [5] Jaensch, M. et al. (1990) Phytochemistry 29: 3587–3590.