Planta Med 2007; 73 - P_411
DOI: 10.1055/s-2007-987191

Securidacaxanthones B and C, xanthones from Securidaca longepedunculata (Polygalaceae)

AL Meli 1, FN Ngninzeko 1, PC Castilho 2, JD Wansi 3, V Kuete 4, D Lontsi 1, VP Beng 4, MI Choudhary 5, BL Sondengam 1
  • 1Department of Organic Chemistry, Faculty of Science, University of Yaounde I, PO Box 812, Yaounde, Cameroon
  • 2Centro de Quimica da Madeira, Dept. Quimica, Univ. Madeira, Campus Universitario da Penteada, 9000–390 Funchal, Portugal
  • 3Department of Chemistry, Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon
  • 4Department of Biochemistry, Faculty of Science, University of Yaounde I, PO Box 812, Yaounde, Cameroon
  • 5International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan

New compounds 1,5-dihydroxy-3,4,6,7,8-pentomethoxyxanthone (1) and 5-O-prenyl-1-hydroxy-,3,4,6,7,8-pentamethoxyxanthone (2), together with seven known compounds: 2-hydroxy-1,7-dimethoxyxanthone (3), 1,7-dihydroxyxanthone, 1,7-dihydroxy-4-methoxyxathanthone, β-sitosterol, 3-O-β-D-glucopyranosyl-β-sitosterol, quercetin-3-O-β-galactopyranoside and 3-hydroxy-6-methoxysalicylic acid, were isolated from the ethyl acetate fraction of the root part (whole root) of Securidaca longepedunculata Fresen. The structures of these compounds were established by means of spectroscopic (NMR) methods. Some of the isolated xanthones showed moderate antimicrobial activity.

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Acknowledgements: CQM is funded by Fundação para a Ciência e Tecnologia (FCT) and FEDER. This work had financial support from programme INTERREG, project BIOPOLIS. A. Meli Lannang, is thankful to the TWAS for financial support for research and advanced training at the H.E.J Research Institute of Chemistry, International Center of Chemical Sciences, Pakistan.

References: [1] Meli AL, Lontsi D, Ngounou FN, Sondengam BL, Nkengfack AE, Heerden FR, Assob JCN, (2006) Fitoterapia 77: 199–202.