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DOI: 10.1055/s-2007-986923
Antihelicobacterial and antioxidant activities of Mongolian medicinal plants
Biological activities of Mongolian medicinal plants are not so well investigated. Gastric ulcer created by Helicobacter pylori is one of the main diseases among Mongolians. Therefore, the aim of this study was the evaluation of the antihelicobacterial and antioxidant activities of 45 methanolic plant extracts belonging to 36 species of 19 families, which were selected on the basis of their traditional medicinal use. The disc diffusion method [1] and the DPPH assay [2] were used to evaluate these activities. A remarkable antihelicobacterial activity was obtained with the extract of Thymus dahuricus root (Table 1), which might be therefore a reasonable drug in the prevention of gastric ulcer. The strongest antioxidant activity was shown by the Bergenia crassifolia root extract (Table 2).
Table 1. Activity against H. pylori lab strains
Inhibition zone Ø a, mm |
||
Plant species, parts used b |
H. pylori
|
H. pylori
|
Thymus dahuricus, root |
>40 |
>40 |
Artemisia changaica, leaves |
28 |
28 |
Juniperus pseudosabina, stem |
28 |
26 |
Artemisia pectinata, flowers |
22 |
22 |
Juniperus sibirica, leaves |
22 |
20 |
Ciprofloxan (ref, 5µg/disc) |
>40 |
>40 |
Table 2. Antioxidant activity
Plant species, parts used |
DPPH radical scavenging activity IC50, µg/ml |
Bergaenia crassifolia, root |
11.75 |
Saxifraga hirculis, leaves |
12.06 |
Potentilla viscose, flowers |
15.35 |
Ephedra equisetina, leaves |
22.19 |
Reaumuria soongarica, flowers |
25.67 |
Rutin (ref.) |
17.05 |
a Disc Ø: 9mm, b Concentration of MeOH extracts: 500µg/disc, n=3
Acknowledgements: Asia-Pacific UNINET, Austrian Exchange Service (OEAD), Asian Research Centre (ARC) at National University of Mongolia.
References: [1] Pharmacopoeia Europaea, ed. 5 (2005) [2] Hatano, T et al. (1988) Chem. Pharm. Bull. 36(6): 2090–2097