Resistin- and Obesity-associated Metabolic Diseases

M. A. Lazar

doi:10.1055/s-2007-985897

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 2007; 39(10): 710-716
DOI: 10.1055/s-2007-985897

Review

Resistin- and Obesity-associated Metabolic Diseases

M. A. Lazar¹

¹Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, USA

Abstract

The link between obesity and diabetes is strong as well as complex. Fat cells produce many circulating regulators of insulin sensitivity, including pro-inflammatory cytokines. In rodents, resistin is produced by adipose tissue, and is a significant regulator of glucose metabolism and insulin sensitivity. In humans, resistin is derived made mainly from macrophages. Given the emerging interrelationship between inflammation and metabolic disease, hyperresistinemia may be a biomarker, and/or a mediator, of metabolic and inflammatory diseases in humans as well as in rodents.

Key words

obesity - insulin resistance - resistin - adipokine

Volltext

Referenzen

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Correspondence

M. A. Lazar

Division of Endocrinology

Diabetes and Metabolism

Department of Medicine and The Institute for Diabetes

Obesity and Metabolism

University of Pennsylvania School of Medicine

19104-6149 Philadelphia

USA

Telefon: +1/215/898 01 98

Fax: +2/215/898 54 08

eMail: lazar@mail.med.upenn.edu