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DOI: 10.1055/s-2007-985602
Chiral Ligands with an Isoborneol-10-sulfonamide Structure: A Ten-Year Odyssey
Publikationsverlauf
Publikationsdatum:
22. August 2007 (online)
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Abstract
The isoborneol-10-sulfonamide unit represents a new type of chiral structure that has been successfully prepared and used in different reactions of organometallic addition to aldehydes and ketones. The obtained results were excellent in some cases, and this type of ligand is unique as it is able to promote the enantioselective addition of dialkylzinc reagents to simple ketones. The scope of these catalyzed reactions, together with some synthetic applications, is outlined. References to important related work from others are also included.
1 Introduction
2 First-Generation Ligands
2.1 Enantioselective Addition of Organozinc Reagents to Aldehydes
2.2 Enantioselective Addition to Ketones
3 Second-Generation Ligands
3.1 Enantioselective Addition of Organozinc Reagents to Aldehydes
3.2 Enantioselective Addition to Ketones
4 Third-Generation Ligands
5 Outlook
Key words
addition reactions - aldehydes - asymmetric catalysis - ketones - ligands
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